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Database: UniProt
Entry: A0A0R2UA12_9GAMM
LinkDB: A0A0R2UA12_9GAMM
Original site: A0A0R2UA12_9GAMM 
ID   A0A0R2UA12_9GAMM        Unreviewed;       429 AA.
AC   A0A0R2UA12;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-SEP-2017, entry version 12.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377,
GN   ECO:0000313|EMBL:KRO96325.1};
GN   ORFNames=ABS10_03090 {ECO:0000313|EMBL:KRO96325.1};
OS   SAR86 cluster bacterium BACL1 MAG-120820-bin45.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; SAR86 cluster.
OX   NCBI_TaxID=1655612 {ECO:0000313|EMBL:KRO96325.1, ECO:0000313|Proteomes:UP000051027};
RN   [1] {ECO:0000313|EMBL:KRO96325.1, ECO:0000313|Proteomes:UP000051027}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BACL1 MAG-120820-bin45 {ECO:0000313|EMBL:KRO96325.1};
RA   Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C.,
RA   Pinhassi J., Andersson A.;
RT   "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRO96325.1}.
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DR   EMBL; LICS01000003; KRO96325.1; -; Genomic_DNA.
DR   Proteomes; UP000051027; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051027};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897}.
FT   DOMAIN      126    257       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      337    406       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     134    141       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   429 AA;  48694 MW;  A56E81CD6FFD0B94 CRC64;
     MKFWSECTQK LEAKLSQEEF NTWIKPLTAD INNNNLEISA PNDFVLTYVR DNLGQIIENL
     VNTTDESLNV KFKTLDKSTF VDKLNVTEKY TPGLVKTFTF DTFVEGKSNH MALAAAKQVA
     GNPTGDYNPL FIYGGVGLGK THLMHAVGNH ILNSNKPKRI VYVHSEKFVT DMVKALQLGA
     MSEFKEFYRN ADALLIDDIQ FFAGKEQSQE EFFHTFNALL DRNHQMILTC DKYPKEIDGL
     EERLKSRLGW GLPVTIEPPE LETRAAVLLS KANSMGVTLP NDCAIYIAQR IRSNIRELEG
     ALKRVVANSR FSNQEIDIPF VKESLKDLFV ISAKMVSIDN IQKTVAEYYN IKLSDILSKR
     RSRSITRPRQ LAMALTKELT NHSLPEIGEA FNGRDHTTVL HACGKIKELR KEIPSLEEDY
     RNLNRALTN
//
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