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Database: UniProt
Entry: A0A0R2W7Y4_9GAMM
LinkDB: A0A0R2W7Y4_9GAMM
Original site: A0A0R2W7Y4_9GAMM 
ID   A0A0R2W7Y4_9GAMM        Unreviewed;       538 AA.
AC   A0A0R2W7Y4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=ABS23_00440 {ECO:0000313|EMBL:KRP20262.1};
OS   SAR92 bacterium BACL16 MAG-120619-bin48.
OC   Bacteria; Proteobacteria; Gammaproteobacteria; Cellvibrionales;
OC   Porticoccaceae; SAR92 clade.
OX   NCBI_TaxID=1655625 {ECO:0000313|EMBL:KRP20262.1, ECO:0000313|Proteomes:UP000051070};
RN   [1] {ECO:0000313|EMBL:KRP20262.1, ECO:0000313|Proteomes:UP000051070}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BACL16 MAG-120619-bin48 {ECO:0000313|EMBL:KRP20262.1};
RA   Hugerth L.W., Larsson J., Alneberg J., Lindh M.V., Legrand C.,
RA   Pinhassi J., Andersson A.;
RT   "Metagenome-Assembled Genomes uncover a global brackish microbiome.";
RL   Submitted (OCT-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00911680}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KRP20262.1}.
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DR   EMBL; LIDE01000002; KRP20262.1; -; Genomic_DNA.
DR   Proteomes; UP000051070; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-UniRule.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-UniRule.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF2; PTHR30050:SF2; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 2.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747950};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051070};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00911664};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00747996};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00911684};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00747895};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051070}.
FT   DOMAIN      235    431       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      446    515       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     243    250       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   538 AA;  60089 MW;  52AA9C011750F43B CRC64;
     MDVSRFSQHQ YGETANSDSL LSFDAIQSIW SSCANRLSGE LPAQQFNTWI RPLKVKLFSH
     SHSPHSAPAN PNAFDSSQGT DIASVGAGQQ VQLLAPNRFI EDWVKSKFLA RIEELFVEFG
     GGHCSVAVIA QAESAPIFRE QQRSIAAQPD QPLIGDRVES VVADPTPART RDIILPDAPQ
     ILRPLAAPAI ITSAAEHSLK SNLNSAFTFD TFVEGKSNQL ALAAAQQVAE NPGGSYNPLF
     IYGGVGLGKT HLMHAVGNAM RERKPDAKIV YLHSERFVAD MVKALQLKAI DEFKQFYRSV
     DALLIDDIQF FAGKDRSQEE FFHTYNALLE RGQQMILTCD RYPKEIDGVE ERLKSRFGWG
     LTVAVEPPEL ETRVAILINK AEQTGMDLSR DAAFFIAQRI RSNVRELEGA LKRVMAHAQF
     SGRVIDIDLI RESLKDLLAL QDKLVTIDNI QRVVADYYKL KMSDLLSKRR SRSVARPRQI
     AMALAKELTN YSLPEIGEAF GGRDHTTVLH ACRKVKELEQ SDREVERDLK NLFRTLSN
//
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