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Database: UniProt
Entry: A0A0R3NL32_DROPS
LinkDB: A0A0R3NL32_DROPS
Original site: A0A0R3NL32_DROPS 
ID   A0A0R3NL32_DROPS        Unreviewed;      2642 AA.
AC   A0A0R3NL32;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 14.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Dpse\GA24638 {ECO:0000313|EMBL:KRT01607.1};
GN   ORFNames=Dpse_GA24638 {ECO:0000313|EMBL:KRT01607.1}, GA24638
GN   {ECO:0000313|FlyBase:FBgn0246028};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|EMBL:KRT01607.1, ECO:0000313|Proteomes:UP000001819};
RN   [1] {ECO:0000313|EMBL:KRT01607.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA   Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA   van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA   Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA   Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA   Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA   Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA   Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura:
RT   chromosomal, gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2] {ECO:0000313|EMBL:KRT01607.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CM000071; KRT01607.1; -; Genomic_DNA.
DR   RefSeq; XP_015039169.1; XM_015183683.1.
DR   GeneID; 6898122; -.
DR   FlyBase; FBgn0246028; Dpse\GA24638.
DR   Proteomes; UP000001819; Chromosome 3.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001819};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      125    404       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      688    918       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1756   2059       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2111   2361       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2367   2428       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   2642 AA;  301160 MW;  504C556F5CE82209 CRC64;
     MSDDQAGAND EKAVAKHQVV AYTQRSQVKH ENRHIQLVRE YGFHPRTKAS VEDGDVLPRK
     FEPFPEDMYG KPLEEIDTFI YEETFCVVSK RFRKNYIHRF TGTKSLFLFH PWSPARRVCV
     YIATNQFFDY CVMATILFNC IFLAMTETVE EAEYIFLAIY SIEMVIKIIA KGFLLNKYTY
     LRNPWNWLDF VVITSGYATI GMEVGNLAGL RTFRVLRALK TVSIMPGLKT IINALLHSFR
     QLAEVMTLTI FCLMVFALFA LQVYMGELRN KCVRHVPSEW SNVSHLDWHM WVNDTDNWLF
     DDEEMPVLCG NLTGARHCPF GYMCICVGEN PNHENTNFDN FMWSMLTTFQ LITLDYWENV
     YNMVLATCGP MSVIFFTVVV FFGSFYLINL MLAVVALSYE EEAEITNEER KKDLLDHRDD
     STFSFDPSVL NVKKLNKNNK KRIDSRKGVL LASYSKKKTR RKKTKGGKET NGNGNGNGNG
     SNGHENDANK SPSATPSPGP SPRHSATERP SALTRQAQKQ YKQIEQQQHH QHLLAKVPAA
     ATPKNRISFQ EEPQKNPNML YPSDNKGQLI ASSRQTSSNS SGVNRESSQD DSGVVDDHEE
     QDPANELGHV STVELALSPR EVRLIKCNGN IARIKNHNVY ALHQEFSSEV VVIDDLPDRN
     CDRCVHCCAD YESWLQFQNC LYKVVRDPLF ELAITLCIVL NTAFLAMEHH GMSESFRNAL
     DVGNKVFTSI FTFECIVKLM ALSKDFFLCG WNIFDLLIVT ASLLDIIFEL VDGLSVLRGL
     RLLRVLKLAQ SWTTMKVLLS IIISTIGALG NLTLILVIVI YIFAVIGMQL FSKDYTAEKF
     DPDPVPRWNF NDFFHSFMMI FRILCGEWIE PLWDCMRAEE EQGASTCFAI FLPTLVMGNF
     MVLNLFLALL LNSFNSEELK SKKEIFKKKE VGEESKLARS IERVRDLIRK KRQERKDRKE
     RKFAEKFQQI VLEAQAQAHA QSQGQAQGGM EMDKSNLLAE TKFHRLSYQE SMNRPVSGSD
     FGFQIPLRDG LHTIVDGLEY DEASDVPEQI QLQDQPLPPI TDSLPPTYET AIMSAHSNNL
     TPFALAERRL QHQISSGVST QQNDSRDEAT YTESIELRLL GQYNSTDTDP YANDQRSGSF
     NRGDSFQDNS SRRYGSEEHD EAYLKYQKSL LTRSPSYRKS LDRLSQSSGH SQRSLLKSEE
     AEMRRHSSGH SLNSISIEQE ELLSQQGNLR EELLNCEQKE LFQFLQEDNE MPKSNLSYIS
     SNLMRSRRSS SQGHQESEAL VEHSEFDNII QSFEKELEEI KRSTTSLERK LSTLSEPSPA
     ADEATKAIME HIAIITGASE RTAADEVVHP LNPYDSYDLS SVPRRSQSVS SAAQRQSVKI
     KRRSLEKQRK IDEDFSISNE IRKICDQIHA PFVAMEAMAV AATSQGPGAS QSPFTRRKID
     PFTVQFDRFK RLSLIERLEE LPEEEKPIST LRIESEKMPR KFLNSDQLRL DSLSLKSTNS
     YENLLIQKQK LVLPLSTGVP ATPPTSLKSS IEPPTLAQIS SLKVTPTPTP PLAALTEHQQ
     HFHATSIQTA PSHGHGQRHT HGSGHRHGNG HSQAHPTAGQ RRRPMEHPQS TLDKAASFQS
     ARTESHSSGA ADTSSALALA LAHTHKTEQS DQPEKAAQKP SAFTRLTEKP WHCLVSYVDD
     LTVGGRRNSQ GAYNDPMTFP SYGQAKPPKV PDDCFPQKCY DHFYFRCPWF MSCMDTPSAK
     QWTRIRTAVL TVVDTPAFEW FVLVLIFASS ITLCFEDIYL DSNKTLKRVL YWTNFSFCLI
     FVVEMILKWL ALGFSKYFTS FWTILDFIIV FVSVFSLLIE ENENLKVLRS LRTLRALRPL
     RAISRWQGMR IVVNALMYAI PSIFNVLLVC LVFWLIFSIM GVQFFGGKFF KCVNEMGELL
     PITVSTLHTL PIWSRRTIYL SCVTVQTHPT HISFSIYCVQ EVNDKWDCIE QNYTWINSKI
     TFDHVGMGYL ALLQVATFEG WMEVMADAVD ARGVDLQPQR EANLYAYIYF VIFIVCGSFF
     TLNLFIGVII DNFNMLKKKY EGGVLEMFLT ESQKHYYTAM KKLGRKKPQK VIKRPINHFL
     AMFYDLSNSR RFEIAIFVLI FLNMLTMGIE HYDQPHAVFF ILEVSNAFFT TVFGLEAIVK
     IVGLRYHYFT VPWNVFDFLL VLASIFGILM EDIMIDLPIS PTLLRVVRVF RIGRILRLIK
     AAKGIRKLLF ALVVSLPALF NIGALLGLIT FIYAILGMSL FGHVKLQGAL DDMVNFQTFG
     RSMQLLFRLM TSAGWNDVLE SLMIQPPDCD PFFNRQTNGD CGHPLLAITY FTSFIIISYM
     IVINMYIAII LENFNQAHQE EEIGIVEDDL EMFYIRWSKY DPHATQFIHF SQLSDFIASL
     DPPLGISKPN NVALVSFNLP ISKGNKIHCL DILHALVKHV LGHVEETDNF KQLQEQMDVK
     FKKQFPTRKE LEIVSSTRIW KRQEKAAKTI QTGWKDYLRR KNEKERSNSG DSATQTSSPG
     GWQSKLSALN FFHLQVSRRG TACSSRASSR KSSRASDGSD LSELAGPWLN LPLMLVSGAD
     DVVKDIKQQS DDMGKRCYKS HDQHYHLSLC LRQRLWCGLR HRHCDSSIRL RQRQTTGGGG
     AG
//
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