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Database: UniProt
Entry: A0A0R3NLI0_DROPS
LinkDB: A0A0R3NLI0_DROPS
Original site: A0A0R3NLI0_DROPS 
ID   A0A0R3NLI0_DROPS        Unreviewed;      2862 AA.
AC   A0A0R3NLI0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Dpse\GA24638 {ECO:0000313|EMBL:KRT01612.1};
GN   ORFNames=Dpse_GA24638 {ECO:0000313|EMBL:KRT01612.1}, GA24638
GN   {ECO:0000313|FlyBase:FBgn0246028};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|EMBL:KRT01612.1, ECO:0000313|Proteomes:UP000001819};
RN   [1] {ECO:0000313|EMBL:KRT01612.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA   Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA   van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA   Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA   Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA   Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA   Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA   Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura:
RT   chromosomal, gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2] {ECO:0000313|EMBL:KRT01612.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CM000071; KRT01612.1; -; Genomic_DNA.
DR   RefSeq; XP_015039174.1; XM_015183688.1.
DR   EnsemblMetazoa; FBtr0278940; FBpp0277378; FBgn0074990.
DR   GeneID; 6898122; -.
DR   FlyBase; FBgn0246028; Dpse\GA24638.
DR   Proteomes; UP000001819; Chromosome 3.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001819};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      125    404       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      688    918       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1751   2017       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2069   2319       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     2325   2386       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   2862 AA;  323795 MW;  9EAED3889EACDF95 CRC64;
     MSDDQAGAND EKAVAKHQVV AYTQRSQVKH ENRHIQLVRE YGFHPRTKAS VEDGDVLPRK
     FEPFPEDMYG KPLEEIDTFI YEETFCVVSK RFRKNYIHRF TGTKSLFLFH PWSPARRVCV
     YIATNQFFDY CVMATILFNC IFLAMTETVE EAEYIFLAIY SIEMVIKIIA KGFLLNKYTY
     LRNPWNWLDF VVITSGYATI GMEVGNLAGL RTFRVLRALK TVSIMPGLKT IINALLHSFR
     QLAEVMTLTI FCLMVFALFA LQVYMGELRN KCVRHVPSEW SNVSHLDWHM WVNDTDNWLF
     DDEEMPVLCG NLTGARHCPF GYMCICVGEN PNHENTNFDN FMWSMLTTFQ LITLDYWENV
     YNMVLATCGP MSVIFFTVVV FFGSFYLINL MLAVVALSYE EEAEITNEER KKDLLDHRDD
     STFSFDPSVL NVKKLNKNNK KRIDSRKGVL LASYSKKKTR RKKTKGGKET NGNGNGNGNG
     SNGHENDANK SPSATPSPGP SPRHSATERP SALTRQAQKQ YKQIEQQQHH QHLLAKVPAA
     ATPKNRISFQ EEPQKNPNML YPSDNKGQLI ASSRQTSSNS SGVNRESSQD DSGVVDDHEE
     QDPANELGHV STVELALSPR EVRLIKCNGN IARIKNHNVY ALHQEFSSEV VVIDDLPDRN
     CDRCVHCCAD YESWLQFQNC LYKVVRDPLF ELAITLCIVL NTAFLAMEHH GMSESFRNAL
     DVGNKVFTSI FTFECIVKLM ALSKDFFLCG WNIFDLLIVT ASLLDIIFEL VDGLSVLRGL
     RLLRVLKLAQ SWTTMKVLLS IIISTIGALG NLTLILVIVI YIFAVIGMQL FSKDYTAEKF
     DPDPVPRWNF NDFFHSFMMI FRILCGEWIE PLWDCMRAEE EQGASTCFAI FLPTLVMGNF
     MVLNLFLALL LNSFNSEELK SKKEEVGEES KLARSIERVR DLIRKKRQER KDRKERKFAE
     KFQQIVLEAQ AQAHAQSQGQ AQGGMEMDKS NLLAETKFHR LSYQESMNRP VSGSDFGFQI
     PLRDGLHTIV DGLEYDEASD VPEQIQLQDQ PLPPITDSLP PTYETAIMSA HSNNLTPFAL
     AERRLQHQIS SGVSTQQNDS RDEATYTESI ELRLLGQYNS TDTDPYANDQ RSGSFNRGDS
     FQDNSSRRYG SEEHDEAYLK YQKSLLTRSP SYRKSLDRLS QSSGHSQRSL LKSEEAEMRR
     HSSGHSLNSI SIEQEELLSQ QGNLREELLN CEQKELFQFL QEDNEMPKSN LSYISSNLMR
     SRRSSSQGHQ ESEALVEHSE FDNIIQSFEK ELEEIKRSTT SLERKLSTLS EPSPAADEAT
     KAIMEHIAII TGASERTAAD EVVHPLNPYD SYDLSSVPRR SQSVSSAAQR QSVKIKRRSL
     EKQRKIDEDF SISNEIRKIC DQIHAPFVAM EAMAVAATSQ GPGASQSPFT RRKIDPFTVQ
     FDRFKRLSLI ERLEELPEEE KPISTLRIES EKMPRKFLNS DQLRLDSLSL KSTNSYENLL
     IQKQKLVLPL STGVPATPPT SLKSSIEPPT LAQISSLKVT PTPTPPLAAL TEHQQHFHAT
     SIQTAPSHGH GQRHTHGSGH RHGNGHSQAH PTAGQRRRPM EHPQSTLDKA ASFQSARTES
     HSSGAADTSS ALALALAHTH KTEQSDQPEK AAQKPSAFTR LTEKPWHCLV SYVDDLTVGG
     RRNSQGAYND PMTFPSYGQA KPPKVPDDCF PQKCYDHFYF RCPWFMSCMD TPSAKQWTRI
     RTAVLTVVDT PAFEWFVLVL IFASSITLCF EDIYLDSNKT LKRVLYWTNF SFCLIFVVEM
     ILKWLALGFS KYFTSFWTIL DFIIVFVSVF SLLIEENENL KVLRSLRTLR ALRPLRAISR
     WQGMRIVVNA LMYAIPSIFN VLLVCLVFWL IFSIMGVQFF GGKFFKCVNE MGELLPITEV
     NDKWDCIEQN YTWINSKITF DHVGMGYLAL LQVATFEGWM EVMADAVDAR GVDLQPQREA
     NLYAYIYFVI FIVCGSFFTL NLFIGVIIDN FNMLKKKYEG GVLEMFLTES QKHYYTAMKK
     LGRKKPQKVI KRPINHFLAM FYDLSNSRRF EIAIFVLIFL NMLTMGIEHY DQPHAVFFIL
     EVSNAFFTTV FGLEAIVKIV GLRYHYFTVP WNVFDFLLVL ASIFGILMED IMIDLPISPT
     LLRVVRVFRI GRILRLIKAA KGIRKLLFAL VVSLPALFNI GALLGLITFI YAILGMSLFG
     HVKLQGALDD MVNFQTFGRS MQLLFRLMTS AGWNDVLESL MIQPPDCDPF FNRQTNGDCG
     HPLLAITYFT SFIIISYMIV INMYIAIILE NFNQAHQEEE IGIVEDDLEM FYIRWSKYDP
     HATQFIHFSQ LSDFIASLDP PLGISKPNNV ALVSFNLPIS KGNKIHCLDI LHALVKHVLG
     HVEETDNFKQ LQEQMDVKFK KQFPTRKELE IVSSTRIWKR QEKAAKTIQT GWKDYLRRKN
     EKERSNSGDS ATQTSSPGGW QSKLSALNFF HLQVSRRGTA CSSRASSRKS SRASDGSDLS
     ELAGPWLNLP LMLVSGADDV VKDIKQQSDD MGKRGSIFVE APRASRRRSF YNFFLRHQDA
     VDDSLTSPSV HRKTAINPTT NTTTSASVSV SASGAASATA TATAASASDS DRQQVVGGPV
     NSRKRASSFI RKKPPLERGL SAQSALRVNK NAFVSEGPAP EVIVTRPSPD QQTHPHMHAL
     GLRPDNATLV HVLVHRESEE YKEEDEGSLS STGNGNGNGN GHDKPKPPQI RISTGSSESP
     MDTSLMPTVQ IMVDSPKEPP RGDFSTELAA TSTAVTIGVE VDPSPIDVNV QGDTSQVFYD
     YNPDKATGNE IVEIDTLDED EEQTAAERGI EAEALPAEDQ QR
//
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