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Database: UniProt
Entry: A0A0R3NPF8_DROPS
LinkDB: A0A0R3NPF8_DROPS
Original site: A0A0R3NPF8_DROPS 
ID   A0A0R3NPF8_DROPS        Unreviewed;      4008 AA.
AC   A0A0R3NPF8;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   07-JUN-2017, entry version 12.
DE   SubName: Full=Uncharacterized protein, isoform O {ECO:0000313|EMBL:KRT02866.1};
GN   Name=Dpse\GA10593 {ECO:0000313|EMBL:KRT02866.1};
GN   ORFNames=Dpse_GA10593 {ECO:0000313|EMBL:KRT02866.1}, GA10593
GN   {ECO:0000313|FlyBase:FBgn0070650};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|EMBL:KRT02866.1, ECO:0000313|Proteomes:UP000001819};
RN   [1] {ECO:0000313|EMBL:KRT02866.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA   Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA   van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA   Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA   Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA   Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA   Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA   Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura:
RT   chromosomal, gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2] {ECO:0000313|EMBL:KRT02866.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
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DR   EMBL; CM000071; KRT02866.1; -; Genomic_DNA.
DR   RefSeq; XP_015040428.1; XM_015184942.1.
DR   GeneID; 4805077; -.
DR   FlyBase; FBgn0070650; Dpse\GA10593.
DR   Proteomes; UP000001819; Chromosome 3.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 1.
DR   Pfam; PF02026; RyR; 2.
DR   Pfam; PF00622; SPRY; 1.
DR   SMART; SM00449; SPRY; 1.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   PROSITE; PS50188; B302_SPRY; 1.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001819};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819}.
FT   DOMAIN      311    536       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
SQ   SEQUENCE   4008 AA;  455329 MW;  0CDADF6E5B4C5FAD CRC64;
     MGAGRLLSGC HAGQRGHQLG LRWTQCFSLN GELLMDALGG ETTFAEVTAE GVGFVPACTL
     GVGQKARLIY GQDVDSLKFF TTCGLQEGYE PFCVNMRRPV THWYTKDQPI FENTEEMPDC
     RIDVTRIPGG ADTPPHLKIS HNTFETMEKA NWEFLRLSLP VTCMGEFISE QEKARRWEEI
     KIRQYRLMRE AQAAAAQAQN AQTAAHMDHM LTGGFNMNDI KGLTRGNFDD HAEAEAEHMM
     RPPRTPRKGS LTRNITFESD MSAALDEMQR STSVLDMNGL GEEIDDKKKR GRSPFKFFSK
     KSRDQSREKM GSRTLDTSLE RRNTVAHGRN VVNQQMTTRA PTLRLNNAEI PSSPVQQQAQ
     QGPKQLSSSN LGQPPVESSG NEMFDADCLK LINEYFYGVR IFPGQDPTHV YVGWVTTQYH
     LHSREFNKNK VRRGSVYIED DYEVPIERID RQSCYVVRAD ELFNEVTQDA SGKGASQGMF
     VGCFVDTATG IIRFTCEGKE TSHRWMMEPD TKLFPAIFVE ATSKEILQIE LGRTPTTLPL
     SAAVLPTSDK HINPQSPPRL KVQCLRPHQW ARVPNTSLQV HALKLSDIRG WSMLCEDPVS
     MLALHIPEED RCIDILELIE MDKLLSFHAH TLTLYAALCY QSNYRAAHAL CQHVDQKQLL
     YAIRSEYMSG PLRQGFYDLL IALHLESHAT TMEVCKNEYI TPLGTELKEL YADEEMQHSL
     RSLVTESVRP QLRMTEITPP VIATSSMPSV SSEPIPDIDQ LYSPKFPLEV VRQFVMEALK
     DAVEINQVHN RDPIGWTNEN LFLPLIKLTD RLLLVGVLTD EDVQKLLVMV DPETWDAKFE
     KEGKDEHRKG LLTMKMAEGA KLQMCYLLHH LYDTQLRHRV ESIIAFSHDF VGDLQTDQLR
     RYIEIKQSDL PSAVAAKKTK EFRCPPREQM NQILCFKNLE SDDQDNCTCG LELRGRLGDF
     HDSLMQKVSL NALQEPDGTE SGTAIEEIKT GPITKIYNFI NTVKELEEGP KEVEEPEKKT
     PEEVFRKVLI KQIVSWAEES PIENPKLVRE MFSLLLRQYD TVGELVRALE KTYVINNRAR
     EDVAEMWVGL SQIRALLPVQ MSQEEEELMR KRLWKLVNNA TFFQHPDLIR ILRVHENVMA
     VMMNTLGRRA QAQSDAPAQP EGGEGVPSKE KDTSHEMVVA CCRFLCYFCR TGRQNQKAMF
     DHFDFLLDNA NILLARPSLR GSTPLDVAYS SLMENTELAL ALREHYLEKI AVYLSRCGLQ
     SNSELIEKGY PDLGWDPVEG ERYLDFLRYC VWVNGESVEE NANLVIRLLI RRPECLGPAL
     RGEGEGLFRA IVEANRMSER ISDRCKMQDE AEGTTIAGLN FTHPLPESEE DEDYIDTGAA
     ILNFYCTLVD LLGRCAPDAS VIEQGKNESL RARAILRSLV PLEDLQGVLS LKFTLTQTGP
     GEEKAKTDMP SGLLPNNKQS IVLFLERVYG IETQDLFYRL LEDAFLPDLR TATILDKSDG
     SESDMALAMN RYIGNSILPL LIKHSKFYNE AENYASLLDA TLHTVYRLSK NRMLTKGQRE
     AVSDFLVALT SQMQPAMLLK LLRKLTVDVS KLSEYTTVAL RLLTLHFDRC AKYYGSTQGQ
     GSYGASSDEE KRLTMLLFSN IFDSLSNMDY DPELFGKALP CLIAIGCALP PDYSLSKNTD
     EDYYGRQMGA PDQPQYVPHP IDTNSVHLDN DLNSLVQKFS EHYHDAWASR RLEGSWTYGE
     IRSENDRKHP RLKPYNMLTE YERERYRDPV RECLKGLLAI GWTVEHSEVD VPLNHRGSTR
     RQSKPQIHDF QNEGSPFNYN PHPVDMSNLT LSREMQNMAE RLAENSHDIW AKKKNEELNG
     CGGVIHPQLV PYDLLTDKEK KKDRERSQEF LKYMQYQGYK LHKPSKGGAV EEGGATQAAV
     ELRFSYSLLE KLIAYLDRAT INMKLLKPST TFSRRTSFKT ATRDIKFFSK VVLPLMEKYF
     STHRNYFIAI ATATNNIGAA SLKEKEMVAS IFCKLAALLR NRLSAFGPDV RITVRCLQVL
     VKGIDARTLT KNCPEFIRTS MLTFFNQTSD DLGNTILNLQ DGKYSHLRGT HLKTSTSLGY
     VNQVVLPVLT AMFDHLAACD YGSDLLLDEI QVASYKILAA LYHLGTDGTL THDRKYLKTE
     IERHRPALGS CLGAYSSCFP VAYLEPHLNK HNQYSLLNRI ADHSLEAQDI MVKMEQCMPN
     LETILSEVDQ FVESDKTYND APHIIDVILP LLCAYLPFWW SQGPDNVSPT SGNHVTMVTA
     DHMNPLLRNV LKMIKKNIGN DNAPWMTRIA AYTQQIIINT SEELLKDPFL PLAERVKKRT
     ENMLHKEDSM RGFIKSATDD TSQVETQLQE DWNLLVRDIY SFYPLLIKYV DLQRNHWLKD
     NIPEAEELYN HVAEIFNIWS KSQYFLKEEQ NFISANEIDN MALIMPTATR RSAISEGAPA
     VGGKVKKKKK NRDKKRDKDK EVQASLMVAC LKRLLPVGLN LFAGREQELV QHCKDRYLKK
     MTEYDVIEFA RNQLTLPDKL DPSDEMSWQH YLYSKLGKSE ETVDEQALEK ANVNSNEKGK
     DKTQETVDRI VAMAKVLFGL HMIDHPQQQS KNVYRSVVSI QRKRAVIACF RQTSLHSLPR
     HRACNIFART YHEQWLNEEN VGQEVMVEDL TQSFEDSEKS KKDEEETDSK PDPLTQLVTT
     FCRGAMTERS GALQEDLLYM SYAQITAKSC GEEEEEGGDE EGGEGAEEGE GTSIHWRMRE
     LMEQEMEKQK LLFHQARLSN RGVAEMVLLH ISASKGIPSE MVMTTLNLGI AILRGGNIDI
     QMGMLNHLKE KKDVGFFTSI AGLMNSCSVL DLDAFERNTK AEEYIPSAGA GLGVGSEGAA
     GEKNMHDAEF TCALFRFIQL TCEGHNLEWQ NYLRTQAGNT TTVNVVICTV DYLLRLQESI
     MDFYWHYSSK EIIDPAGKAN FFKAIGVASQ VFNTLTEVIQ GPCTLNQQAL AHSRLWDAVG
     GFLFLFSHMQ DKLSKHSSQV DLLKELLNLQ KDMITMMLSM LEGNVVNGTI GKQMVDTLVE
     SASNVELILK YFDMFLKLAD LIESPSFHEI DMKNEGWVTP KDFREKMEQS KNYSLEEMDF
     LLACCERNHE GKIDYRAFVE RFHEPSKEIG FNLAVLLTNL SEHMPNEPRL ARFLETAGSV
     LNYFEPFLGR IEILGSSKRI ERVYFEIKDS NIEQWEKPQI RESKRAFFYS IVTEGGDKEK
     LEAFVNFCED AIFEMTHASG LMATDDGGGN VRRDTAYSSY MSEEEEERAA RDPIRRTITA
     VKEGLKFGIH MLSPANIKHQ IGVMQTKSIP ELIVGFFKMI FYMFYYTGYA HFCVVRYIFG
     ILLNLMRGPA PEQEDQLPVV EEETFGRALP PLPLEEPPGT VQAFGLDINK EDNGVYKVVV
     HESPGNSSVE EGGESSPEDG AAIAGELAEG EPYQEPISIV DLLGGDAAKK AAQERQEAQK
     AQEAAMASIE AEAKKSSAAP QETPAVHQID FSQYTHRAVS FLARNFYNLK YVALVLAFSI
     NFMLLFYKVT SFESESEGSA EEELILGSGS GAGVDMNGSG FGGSGDGGSG DGEMEDEIPE
     LVHVNEDFFY MAHVLRIAAC LHSLVSLAML IAYYHLKVPL AIFKREKEIA RRLEFDGLFI
     AEQPEDDDFK SHWDKLVISA KSFPVNYWDK FVKKKVRQKY SETYEFDSIS NLLGMEKSAF
     TAQESEETGI FKYIMNIDWR YQVWKAGVTF TDNAFLYSLW YFSFSVMGNF NNFFFAAHLL
     DVAVGFKTLR TILQSVTHNG KQLVLTVMLL TIIVYIYTVI AFNFFRKFYI QEEDEMVDKK
     CHDMLTCFVF HLYKGVRAGG GIGDEIGDPV GDEYEVYRII FDITFFFFVI IILLAIIQGL
     IIDAFGELRD QLESVKDNME SNCFICGMGK DFFDIVPHGF DTHVQKEHNL ANYMFFLMHL
     INKPDTEYTG QETYVWNMYQ QRSWDFFPVG DCFRKQYEDE LSGGGGGG
//
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