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Database: UniProt
Entry: A0A0R3NRE0_DROPS
LinkDB: A0A0R3NRE0_DROPS
Original site: A0A0R3NRE0_DROPS 
ID   A0A0R3NRE0_DROPS        Unreviewed;      2154 AA.
AC   A0A0R3NRE0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   30-AUG-2017, entry version 12.
DE   SubName: Full=Uncharacterized protein, isoform C {ECO:0000313|EMBL:KRT01456.1};
GN   Name=Dpse\GA15628 {ECO:0000313|EMBL:KRT01456.1};
GN   ORFNames=Dpse_GA15628 {ECO:0000313|EMBL:KRT01456.1}, GA15628
GN   {ECO:0000313|FlyBase:FBgn0075645};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|EMBL:KRT01456.1, ECO:0000313|Proteomes:UP000001819};
RN   [1] {ECO:0000313|EMBL:KRT01456.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA   Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA   van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA   Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA   Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA   Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA   Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA   Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura:
RT   chromosomal, gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2] {ECO:0000313|EMBL:KRT01456.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- SIMILARITY: Belongs to the transient receptor (TC 1.A.4) family.
CC       {ECO:0000256|SAAS:SAAS00788929}.
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DR   EMBL; CM000071; KRT01456.1; -; Genomic_DNA.
DR   RefSeq; XP_015039018.1; XM_015183532.1.
DR   EnsemblMetazoa; FBtr0278747; FBpp0277185; FBgn0075646.
DR   GeneID; 4803359; -.
DR   FlyBase; FBgn0075645; Dpse\GA15628.
DR   Proteomes; UP000001819; Chromosome 3.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0051262; P:protein tetramerization; IEA:InterPro.
DR   Gene3D; 1.20.5.1010; -; 1.
DR   Gene3D; 1.25.40.20; -; 1.
DR   InterPro; IPR020683; Ankyrin_rpt-contain_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR032415; TRPM_tetra.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF16519; TRPM_tetra; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001819};
KW   Ion channel {ECO:0000256|SAAS:SAAS00816195};
KW   Ion transport {ECO:0000256|SAAS:SAAS00816776};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|SAAS:SAAS00816535}.
FT   TRANSMEM    934    954       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1001   1019       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1068   1089       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      940   1282       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1373   1428       TRPM_tetra. {ECO:0000259|Pfam:PF16519}.
SQ   SEQUENCE   2154 AA;  238880 MW;  B86851E833769436 CRC64;
     MVVVDSPLAP QKYLRRISKD FSTVRRYSNT PGSVSTATAV RVSTSAFIAA EAGAHLATNT
     PLDTPVATPR GIRKRRRMRK RSSVSSTLSK VLILNVRDLL KAHAASEHPK EHQPRSWIET
     NFQKRECIKF IPCPKDDTRC CCGQAQITHQ TIQGIESGSP GDLWLPTKHT RPQPTDAYGT
     IEFQGGAHPT KAQYVRLSFD TRPELLVQLF TKEWNLELPK LLITVQGGKA NFDLQAKLKK
     EIRKGLLKAA KTTGAWIFTG GTNTGVTKQV GDALLLEGQQ RTGRVVSIGI APWGIVERNH
     ELLGHNREVP CHSISSPRSK LAVLNNRHAY FLLVDNGTQA KYGAELILRR KLEKFISNLK
     LHPFTHSSTP VVCLVIEGGT NTIRAVLEYV TDSPPVPVVV CDGSGRAADL LAFVHKYASD
     GEEQPVLESM RDYLIGTIQK TFEVGLDQAE KLYQELLQCT RNKNLITVFR IQEKPEGEAQ
     ELDQTILTAL FKSQHLSPPE QLSLALTWNR VDIARSEIFV YGQEWPHGAL DEAMMQALEH
     DRIDFVKLLL ENGVSMKKFL TIPRLEELYN TKHGPANTLG YILRDVRPHI PKGYIYTLHD
     IGLVINKLMG GAYRSYYTRR KFRPIYAKVM NSYANACRKS STYQYQRYAG ANSLSLVTGL
     LPFTSEMALF EFPFNELLIW AVLTKRQQMA LLMWTHGEEA LAKSLVSCKL YKAMAHEAAE
     DDLDTEIYEE LRSYAKEFES KGNKLLDFSY RQDAEKAQRL LTCELHSWSN QSCLSLAVAA
     NHRALLAHPC SQVILADLWM GGLRTRKNTN FKVILGLVMP LYIRQLDFKS KEELQQMPQT
     EEEHLENQNL DNDDSDRSQP DAESALLKAK RSISLRYRMG ANTYNREKVS LTDSDPAQFR
     EFFNLSEYNE IKQHQPLRLK KKFHEFYTAP ITKFWADSIA YMFFLIMFSF TVLVKMGPVP
     RWQEWYSIAY ITTLGFEKVR EIISSEPVAI THKFSVWAWN MWNPCDGAAI ILFLIGLAFR
     FRPNTMDIGR VIYCVDSIYW YLRILNILGV NKYLGPLVTM MGKMVKNMIY FVVLLAVVLM
     SFGVSRQAIL YPNSEPTWRL IREVIAGSIV APGFPGALGH SSRSHNARGG GYGSTFSPGS
     FAAGYHRGHA TASSPTATAT TTTTTSTVRP LSSATATAPE TGSAATPAPH APTGTTFNSS
     EHGHLSGGNL TNVTYQPYFM LYGEVFADDI DPPCGEDPRQ PACVTGHWVT PITMSMYLLI
     ANILLINLLI AVFNNIFNEV NSVSHQVWMF QRFTVVMEYQ QKPVLPPPFI AFCHFYSLLK
     YCVRKAKGLE VQRDNGLKLF LEKDDLERLY DFEEECVEGF FHEQEIILNQ STDERVKNTT
     DRVETMSQKI EDINQKENIQ TATVQNIEFR LRKMEESSEQ ILSHLAVIHR FMSTHTVGTD
     DMRGSAINIP AEIHRIRTIS MSDTDGGGGS SGNGGGGGGG AAVPLVLGAG LNVNSLQVTN
     RRRFNRSLTE VRPDAYILDE GTHFEVVPLP EEPDEVVKSR EALNEQVVRK ASMQSEADSD
     IYLPLSQRPS TCETVKRTPY VTVRQDTGAS TESKDTLTPL GTNDDDQTLV GGDNSDDAAP
     DINFEAARHR ALRQRTVSLC RRNSETYSLA GADINRSHIS LNQLTMLSRR QMSLTQSEPD
     SDKDAPPAAA GSTHPGKSVL HAKPSRNILL KLHSEYTSIT DELESVCHMI ASPTVSLQSN
     KASLDRPKTE MSRAEAAALQ EKKHLKECEE NDYRILEGLF EARGSIDASA EAFESVISVD
     YSHRYPLRRE TAVELSPSKP SAEVDLMGGG GGGGDSSDTS GAGSCSAMGA VSSGFQLKNE
     RPWQRNSSME QQTYPSPLVP SRATSDFLNP PFESSGRLFK KSSESLQKNS STETDYSAHP
     YRFIKQSSNE TNTSLTGSYN VDTPSLTAEP SLDACDSHSA TGISISVGAA GGSAARYQPI
     RTTSIGAADG RQLRDESSSS LQSPELGVQC SAPVTMQAPP AVPTRPMLLK KQFSLDKGKP
     QQAQITAEAM ATPESGIDAA TVAQARVKLI SSLKPQSHTS KLGMNVLKES SSSTEGSREG
     EGLSTTSSAK NSNPALSIPQ ISTHLVQDEI AKLSSNIKSS TESEKDPPYN ETMC
//
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