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Database: UniProt
Entry: A0A0R3NRH3_DROPS
LinkDB: A0A0R3NRH3_DROPS
Original site: A0A0R3NRH3_DROPS 
ID   A0A0R3NRH3_DROPS        Unreviewed;      1915 AA.
AC   A0A0R3NRH3;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=Dpse\GA24638 {ECO:0000313|EMBL:KRT01605.1};
GN   ORFNames=Dpse_GA24638 {ECO:0000313|EMBL:KRT01605.1}, GA24638
GN   {ECO:0000313|FlyBase:FBgn0246028};
OS   Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta;
OC   Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha;
OC   Ephydroidea; Drosophilidae; Drosophila; Sophophora.
OX   NCBI_TaxID=46245 {ECO:0000313|EMBL:KRT01605.1, ECO:0000313|Proteomes:UP000001819};
RN   [1] {ECO:0000313|EMBL:KRT01605.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=15632085; DOI=10.1101/gr.3059305;
RA   Richards S., Liu Y., Bettencourt B.R., Hradecky P., Letovsky S.,
RA   Nielsen R., Thornton K., Hubisz M.J., Chen R., Meisel R.P.,
RA   Couronne O., Hua S., Smith M.A., Zhang P., Liu J., Bussemaker H.J.,
RA   van Batenburg M.F., Howells S.L., Scherer S.E., Sodergren E.,
RA   Matthews B.B., Crosby M.A., Schroeder A.J., Ortiz-Barrientos D.,
RA   Rives C.M., Metzker M.L., Muzny D.M., Scott G., Steffen D.,
RA   Wheeler D.A., Worley K.C., Havlak P., Durbin K.J., Egan A., Gill R.,
RA   Hume J., Morgan M.B., Miner G., Hamilton C., Huang Y., Waldron L.,
RA   Verduzco D., Clerc-Blankenburg K.P., Dubchak I., Noor M.A.,
RA   Anderson W., White K.P., Clark A.G., Schaeffer S.W., Gelbart W.,
RA   Weinstock G.M., Gibbs R.A.;
RT   "Comparative genome sequencing of Drosophila pseudoobscura:
RT   chromosomal, gene, and cis-element evolution.";
RL   Genome Res. 15:1-18(2005).
RN   [2] {ECO:0000313|EMBL:KRT01605.1, ECO:0000313|Proteomes:UP000001819}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MV2-25 / Tucson 14011-0121.94
RC   {ECO:0000313|Proteomes:UP000001819};
RX   PubMed=17994087; DOI=10.1038/nature06341;
RG   Drosophila 12 Genomes Consortium;
RA   Clark A.G., Eisen M.B., Smith D.R., Bergman C.M., Oliver B.,
RA   Markow T.A., Kaufman T.C., Kellis M., Gelbart W., Iyer V.N.,
RA   Pollard D.A., Sackton T.B., Larracuente A.M., Singh N.D., Abad J.P.,
RA   Abt D.N., Adryan B., Aguade M., Akashi H., Anderson W.W.,
RA   Aquadro C.F., Ardell D.H., Arguello R., Artieri C.G., Barbash D.A.,
RA   Barker D., Barsanti P., Batterham P., Batzoglou S., Begun D.,
RA   Bhutkar A., Blanco E., Bosak S.A., Bradley R.K., Brand A.D.,
RA   Brent M.R., Brooks A.N., Brown R.H., Butlin R.K., Caggese C.,
RA   Calvi B.R., Bernardo de Carvalho A., Caspi A., Castrezana S.,
RA   Celniker S.E., Chang J.L., Chapple C., Chatterji S., Chinwalla A.,
RA   Civetta A., Clifton S.W., Comeron J.M., Costello J.C., Coyne J.A.,
RA   Daub J., David R.G., Delcher A.L., Delehaunty K., Do C.B., Ebling H.,
RA   Edwards K., Eickbush T., Evans J.D., Filipski A., Findeiss S.,
RA   Freyhult E., Fulton L., Fulton R., Garcia A.C., Gardiner A.,
RA   Garfield D.A., Garvin B.E., Gibson G., Gilbert D., Gnerre S.,
RA   Godfrey J., Good R., Gotea V., Gravely B., Greenberg A.J.,
RA   Griffiths-Jones S., Gross S., Guigo R., Gustafson E.A., Haerty W.,
RA   Hahn M.W., Halligan D.L., Halpern A.L., Halter G.M., Han M.V.,
RA   Heger A., Hillier L., Hinrichs A.S., Holmes I., Hoskins R.A.,
RA   Hubisz M.J., Hultmark D., Huntley M.A., Jaffe D.B., Jagadeeshan S.,
RA   Jeck W.R., Johnson J., Jones C.D., Jordan W.C., Karpen G.H.,
RA   Kataoka E., Keightley P.D., Kheradpour P., Kirkness E.F.,
RA   Koerich L.B., Kristiansen K., Kudrna D., Kulathinal R.J., Kumar S.,
RA   Kwok R., Lander E., Langley C.H., Lapoint R., Lazzaro B.P., Lee S.J.,
RA   Levesque L., Li R., Lin C.F., Lin M.F., Lindblad-Toh K., Llopart A.,
RA   Long M., Low L., Lozovsky E., Lu J., Luo M., Machado C.A.,
RA   Makalowski W., Marzo M., Matsuda M., Matzkin L., McAllister B.,
RA   McBride C.S., McKernan B., McKernan K., Mendez-Lago M., Minx P.,
RA   Mollenhauer M.U., Montooth K., Mount S.M., Mu X., Myers E., Negre B.,
RA   Newfeld S., Nielsen R., Noor M.A., O'Grady P., Pachter L.,
RA   Papaceit M., Parisi M.J., Parisi M., Parts L., Pedersen J.S.,
RA   Pesole G., Phillippy A.M., Ponting C.P., Pop M., Porcelli D.,
RA   Powell J.R., Prohaska S., Pruitt K., Puig M., Quesneville H.,
RA   Ram K.R., Rand D., Rasmussen M.D., Reed L.K., Reenan R., Reily A.,
RA   Remington K.A., Rieger T.T., Ritchie M.G., Robin C., Rogers Y.H.,
RA   Rohde C., Rozas J., Rubenfield M.J., Ruiz A., Russo S., Salzberg S.L.,
RA   Sanchez-Gracia A., Saranga D.J., Sato H., Schaeffer S.W., Schatz M.C.,
RA   Schlenke T., Schwartz R., Segarra C., Singh R.S., Sirot L., Sirota M.,
RA   Sisneros N.B., Smith C.D., Smith T.F., Spieth J., Stage D.E.,
RA   Stark A., Stephan W., Strausberg R.L., Strempel S., Sturgill D.,
RA   Sutton G., Sutton G.G., Tao W., Teichmann S., Tobari Y.N.,
RA   Tomimura Y., Tsolas J.M., Valente V.L., Venter E., Venter J.C.,
RA   Vicario S., Vieira F.G., Vilella A.J., Villasante A., Walenz B.,
RA   Wang J., Wasserman M., Watts T., Wilson D., Wilson R.K., Wing R.A.,
RA   Wolfner M.F., Wong A., Wong G.K., Wu C.I., Wu G., Yamamoto D.,
RA   Yang H.P., Yang S.P., Yorke J.A., Yoshida K., Zdobnov E., Zhang P.,
RA   Zhang Y., Zimin A.V., Baldwin J., Abdouelleil A., Abdulkadir J.,
RA   Abebe A., Abera B., Abreu J., Acer S.C., Aftuck L., Alexander A.,
RA   An P., Anderson E., Anderson S., Arachi H., Azer M., Bachantsang P.,
RA   Barry A., Bayul T., Berlin A., Bessette D., Bloom T., Blye J.,
RA   Boguslavskiy L., Bonnet C., Boukhgalter B., Bourzgui I., Brown A.,
RA   Cahill P., Channer S., Cheshatsang Y., Chuda L., Citroen M.,
RA   Collymore A., Cooke P., Costello M., D'Aco K., Daza R., De Haan G.,
RA   DeGray S., DeMaso C., Dhargay N., Dooley K., Dooley E., Doricent M.,
RA   Dorje P., Dorjee K., Dupes A., Elong R., Falk J., Farina A., Faro S.,
RA   Ferguson D., Fisher S., Foley C.D., Franke A., Friedrich D.,
RA   Gadbois L., Gearin G., Gearin C.R., Giannoukos G., Goode T.,
RA   Graham J., Grandbois E., Grewal S., Gyaltsen K., Hafez N., Hagos B.,
RA   Hall J., Henson C., Hollinger A., Honan T., Huard M.D., Hughes L.,
RA   Hurhula B., Husby M.E., Kamat A., Kanga B., Kashin S., Khazanovich D.,
RA   Kisner P., Lance K., Lara M., Lee W., Lennon N., Letendre F.,
RA   LeVine R., Lipovsky A., Liu X., Liu J., Liu S., Lokyitsang T.,
RA   Lokyitsang Y., Lubonja R., Lui A., MacDonald P., Magnisalis V.,
RA   Maru K., Matthews C., McCusker W., McDonough S., Mehta T., Meldrim J.,
RA   Meneus L., Mihai O., Mihalev A., Mihova T., Mittelman R., Mlenga V.,
RA   Montmayeur A., Mulrain L., Navidi A., Naylor J., Negash T., Nguyen T.,
RA   Nguyen N., Nicol R., Norbu C., Norbu N., Novod N., O'Neill B.,
RA   Osman S., Markiewicz E., Oyono O.L., Patti C., Phunkhang P.,
RA   Pierre F., Priest M., Raghuraman S., Rege F., Reyes R., Rise C.,
RA   Rogov P., Ross K., Ryan E., Settipalli S., Shea T., Sherpa N., Shi L.,
RA   Shih D., Sparrow T., Spaulding J., Stalker J., Stange-Thomann N.,
RA   Stavropoulos S., Stone C., Strader C., Tesfaye S., Thomson T.,
RA   Thoulutsang Y., Thoulutsang D., Topham K., Topping I., Tsamla T.,
RA   Vassiliev H., Vo A., Wangchuk T., Wangdi T., Weiand M., Wilkinson J.,
RA   Wilson A., Yadav S., Young G., Yu Q., Zembek L., Zhong D., Zimmer A.,
RA   Zwirko Z., Jaffe D.B., Alvarez P., Brockman W., Butler J., Chin C.,
RA   Gnerre S., Grabherr M., Kleber M., Mauceli E., MacCallum I.;
RT   "Evolution of genes and genomes on the Drosophila phylogeny.";
RL   Nature 450:203-218(2007).
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
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DR   EMBL; CM000071; KRT01605.1; -; Genomic_DNA.
DR   RefSeq; XP_015039167.1; XM_015183681.1.
DR   EnsemblMetazoa; FBtr0278940; FBpp0277378; FBgn0074990.
DR   GeneID; 6898122; -.
DR   FlyBase; FBgn0246028; Dpse\GA24638.
DR   Proteomes; UP000001819; Chromosome 3.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 2.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000001819};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000001819};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    771    791       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    800    822       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    828    850       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    882    908       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1037   1061       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1123   1143       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1149   1170       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1182   1200       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1239   1267       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1338   1362       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      767   1070       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1122   1372       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1378   1439       GPHH. {ECO:0000259|Pfam:PF16905}.
SQ   SEQUENCE   1915 AA;  215590 MW;  AE67D5A2254F36F6 CRC64;
     MEMDKSNLLA ETKFHRLSYQ ESMNRPVSGS DFGFQIPLRD GLHTIVDGLE YDEASDVPEQ
     IQLQDQPLPP ITDSLPPTYE TAIMSAHSNN LTPFALAERR LQHQISSGVS TQQNDSRDEA
     TYTESIELRL LGQYNSTDTD PYANDQRSGS FNRGDSFQDN SSRRYGSEEH DEAYLKYQKS
     LLTRSPSYRK SLDRLSQSSG HSQRSLLKSE EAEMRRHSSG HSLNSISIEQ EELLSQQGNL
     REELLNCEQK ELFQFLQEDN EMPKSNLSYI SSNLMRSRRS SSQGHQESEA LVEHSEFDNI
     IQSFEKELEE IKRSTTSLER KLSTLSEPSP AADEATKAIM EHIAIITGAS ERTAADEVVH
     PLNPYDSYDL SSVPRRSQSV SSAAQRQSVK IKRRSLEKQR KIDEDFSISN EIRKICDQIH
     APFVAMEAMA VAATSQGPGA SQSPFTRRKI DPFTVQFDRF KRLSLIERLE ELPEEEKPIS
     TLRIESEKMP RKFLNSDQLR LDSLSLKSTN SYENLLIQKQ KLVLPLSTGV PATPPTSLKS
     SIEPPTLAQI SSLKVTPTPT PPLAALTEHQ QHFHATSIQT APSHGHGQRH THGSGHRHGN
     GHSQAHPTAG QRRRPMEHPQ STLDKAASFQ SARTESHSSG AADTSSALAL ALAHTHKTEQ
     SDQPEKAAQK PSAFTRLTEK PWHCLVSYVD DLTVGGRRNS QGAYNDPMTF PSYGQAKPPK
     VPDDCFPQKC YDHFYFRCPW FMSCMDTPSA KQWTRIRTAV LTVVDTPAFE WFVLVLIFAS
     SITLCFEDIY LDSNKTLKRV LYWTNFSFCL IFVVEMILKW LALGFSKYFT SFWTILDFII
     VFVSVFSLLI EENENLKVLR SLRTLRALRP LRAISRWQGM RIVVNALMYA IPSIFNVLLV
     CLVFWLIFSI MGVQFFGGKF FKCVNEMGEL LPITVSTLHT LPIWSRRTIY LSCVTVQTHP
     THISFSIYCV QEVNDKWDCI EQNYTWINSK ITFDHVGMGY LALLQVATFE GWMEVMADAV
     DARGVDLQPQ REANLYAYIY FVIFIVCGSF FTLNLFIGVI IDNFNMLKKK YEGGVLEMFL
     TESQKHYYTA MKKLGRKKPQ KVIKRPINHF LAMFYDLSNS RRFEIAIFVL IFLNMLTMGI
     EHYDQPHAVF FILEVSNAFF TTVFGLEAIV KIVGLRYHYF TVPWNVFDFL LVLASIFGIL
     MEDIMIDLPI SPTLLRVVRV FRIGRILRLI KAAKGIRKLL FALVVSLPAL FNIGALLGLI
     TFIYAILGMS LFGHVKLQGA LDDMVNFQTF GRSMQLLFRL MTSAGWNDVL ESLMIQPPDC
     DPFFNRQTNG DCGHPLLAIT YFTSFIIISY MIVINMYIAI ILENFNQAHQ EEEIGIVEDD
     LEMFYIRWSK YDPHATQFIH FSQLSDFIAS LDPPLGISKP NNVALVSFNL PISKGNKIHC
     LDILHALVKH VLGHVEETDN FKQLQEQMDV KFKKQFPTRK ELEIVSSTRI WKRQEKAAKT
     IQTGWKDYLR RKNEKERSNS GDSATQTSSP GGWQSKLSAL NFFHLQVSRR GTACSSRASS
     RKSSRASDGS DLSELAGPWL NLPLMLVSGA DDVVKDIKQQ SDDMGKRGSI FVEAPRASRR
     RSFYNFFLRH QDAVDDSLTS PSVHRKTAIN PTTNTTTSAS VSVSASGAAS ATATATAASA
     SDSDRQQVVG GPVNSRKRAS SFIRKKPPLE RGLSAQSALR VNKNAFVSEG PAPEVIVTRP
     SPDQQTHPHM HALGLRPDNA TLVHVLVHRE SEEYKEEDEG SLSSTGNGNG NGNGHDKPKP
     PQIRISTGSS ESPMDTSLMP TVQIMVDSPK EPPRGDFSTE LAATSTAVTI GVEVDPSPID
     VNVQGDTSQV FYDYNPDKAT GNEIVEIDTL DEDEEQTAAE RGIEAEALPA EDQQR
//
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