ID A0A0R3NY16_DROPS Unreviewed; 479 AA.
AC A0A0R3NY16; A0A6I8VX65;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE RecName: Full=Eukaryotic peptide chain release factor GTP-binding subunit {ECO:0000256|ARBA:ARBA00015765};
DE AltName: Full=ERF2 {ECO:0000256|ARBA:ARBA00030845};
DE AltName: Full=Polypeptide release factor 3 {ECO:0000256|ARBA:ARBA00029585};
DE AltName: Full=Translation release factor 3 {ECO:0000256|ARBA:ARBA00030210};
GN Name=LOC6902888 {ECO:0000313|RefSeq:XP_033235169.1};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_033235169.1};
RN [1] {ECO:0000313|RefSeq:XP_033235169.1}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_033235169.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_033235169.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the TRAFAC class translation factor GTPase
CC superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A
CC subfamily. {ECO:0000256|ARBA:ARBA00007249}.
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DR RefSeq; XP_015035963.1; XM_015180477.1.
DR RefSeq; XP_033235169.1; XM_033379278.1.
DR AlphaFoldDB; A0A0R3NY16; -.
DR SMR; A0A0R3NY16; -.
DR EnsemblMetazoa; FBtr0371841; FBpp0333956; FBgn0247306.
DR Proteomes; UP000001819; Chromosome 4.
DR Bgee; FBgn0247306; Expressed in female reproductive system and 3 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd01883; EF1_alpha; 1.
DR CDD; cd03704; eRF3_C_III; 1.
DR CDD; cd04089; eRF3_II; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 2.40.30.10; Translation factors; 2.
DR InterPro; IPR004161; EFTu-like_2.
DR InterPro; IPR031157; G_TR_CS.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000795; T_Tr_GTP-bd_dom.
DR InterPro; IPR009000; Transl_B-barrel_sf.
DR InterPro; IPR009001; Transl_elong_EF1A/Init_IF2_C.
DR InterPro; IPR004160; Transl_elong_EFTu/EF1A_C.
DR PANTHER; PTHR23115:SF36; TR-TYPE G DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR23115; TRANSLATION FACTOR; 1.
DR Pfam; PF00009; GTP_EFTU; 1.
DR Pfam; PF03144; GTP_EFTU_D2; 1.
DR Pfam; PF03143; GTP_EFTU_D3; 1.
DR PRINTS; PR00315; ELONGATNFCT.
DR SUPFAM; SSF50465; EF-Tu/eEF-1alpha/eIF2-gamma C-terminal domain; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF50447; Translation proteins; 1.
DR PROSITE; PS00301; G_TR_1; 1.
DR PROSITE; PS51722; G_TR_2; 1.
PE 3: Inferred from homology;
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000001819}.
FT DOMAIN 53..279
FT /note="Tr-type G"
FT /evidence="ECO:0000259|PROSITE:PS51722"
SQ SEQUENCE 479 AA; 53506 MW; F5C7F93BD518E95F CRC64;
MLKTDPADSW DVDDDTVITP EDEEAEDEFV EGEATPKVSK KKIVKVEENR SKREHVNVVF
IGHVDAGKST IGGQIMSLTG MVDKRTLEKY EREAREKSRE SWYLSWALDT NQEERDKGKT
VEVGRAFFET DRKHFTILDA PGHKSFVPNM IGGAAQADLA VLVISARKGE FETGFDRGGQ
TREHAMLAKT AGVKHLVVLV NKMDDPTVSW DQTRYNECKD KILPYLKKLG FNPAKDLTFM
PCSGLSGYGL KDQIPESICQ WYRGPAFIPF IDELPSLNRK SDGPFIMPIV DKYKDMGTVV
MGKVESGMAR KGQNLLVMPN RTQVAVDQLF SDDFEVTSVG PGENVKIKLK GIEEEDVSPG
FVLCDATNPI KTGKIFDAQV VILEHKSIIC AGYSAVMHIH CAAEEVTVKA LICLVDKKSG
DKSKTRPRFV KQDQVAIMRI ECSGMICLEQ FKLFPQMGRF TLRDENKTIA IGKVLKVVE
//
