ID A0A0R3P7C5_DROPS Unreviewed; 354 AA.
AC A0A0R3P7C5; A0A6I8VIW7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE SubName: Full=Thioredoxin reductase 1, mitochondrial isoform X3 {ECO:0000313|RefSeq:XP_015042311.1};
GN Name=LOC4814288 {ECO:0000313|RefSeq:XP_015042311.1};
OS Drosophila pseudoobscura pseudoobscura (Fruit fly).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea;
OC Drosophilidae; Drosophila; Sophophora.
OX NCBI_TaxID=46245 {ECO:0000313|Proteomes:UP000001819, ECO:0000313|RefSeq:XP_015042311.1};
RN [1] {ECO:0000313|RefSeq:XP_015042311.1}
RP IDENTIFICATION.
RC STRAIN=MV2-25 {ECO:0000313|RefSeq:XP_015042311.1};
RC TISSUE=Whole body {ECO:0000313|RefSeq:XP_015042311.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|ARBA:ARBA00001974};
CC -!- SIMILARITY: Belongs to the class-I pyridine nucleotide-disulfide
CC oxidoreductase family. {ECO:0000256|ARBA:ARBA00007532}.
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DR RefSeq; XP_015042311.1; XM_015186825.2.
DR AlphaFoldDB; A0A0R3P7C5; -.
DR SMR; A0A0R3P7C5; -.
DR EnsemblMetazoa; FBtr0377939; FBpp0338849; FBgn0075294.
DR GeneID; 4814288; -.
DR Proteomes; UP000001819; Chromosome X.
DR Bgee; FBgn0075294; Expressed in female reproductive system and 3 other cell types or tissues.
DR ExpressionAtlas; A0A0R3P7C5; baseline.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0004791; F:thioredoxin-disulfide reductase (NADP) activity; IEA:UniProtKB-EC.
DR GO; GO:0045454; P:cell redox homeostasis; IEA:InterPro.
DR Gene3D; 3.30.390.30; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 2.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR023753; FAD/NAD-binding_dom.
DR InterPro; IPR016156; FAD/NAD-linked_Rdtase_dimer_sf.
DR InterPro; IPR046952; GSHR/TRXR-like.
DR InterPro; IPR004099; Pyr_nucl-diS_OxRdtase_dimer.
DR PANTHER; PTHR42737; GLUTATHIONE REDUCTASE; 1.
DR PANTHER; PTHR42737:SF6; THIOREDOXIN REDUCTASE 2; 1.
DR Pfam; PF07992; Pyr_redox_2; 1.
DR Pfam; PF02852; Pyr_redox_dim; 1.
DR PRINTS; PR00368; FADPNR.
DR PRINTS; PR00411; PNDRDTASEI.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR SUPFAM; SSF55424; FAD/NAD-linked reductases, dimerisation (C-terminal) domain; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000001819}.
FT DOMAIN 6..205
FT /note="FAD/NAD(P)-binding"
FT /evidence="ECO:0000259|Pfam:PF07992"
FT DOMAIN 225..336
FT /note="Pyridine nucleotide-disulphide oxidoreductase
FT dimerisation"
FT /evidence="ECO:0000259|Pfam:PF02852"
SQ SEQUENCE 354 AA; 38339 MW; 87C3C42A03ECDCF0 CRC64;
MVAKLKSGDR TITAQTFVIA VGGRPRYPDI PGAVEYGITS DDLFSLDHEP GKTLVVGAGY
IGLECAGFLK GLGYEPTVMV RSIVLRGFDQ QMAELVASSM DERGIPFLRK TVPLSVTKQD
NGKLLVKYKN TETGEEGEDT YDTVLWAVGR KGLVEDLNLS NAGVTTFKDK IQVDTKEATN
VANIFAVGDI IYGKPELTPV AVLAGRLLAR RLYGGSNQRM DYSDVATTVF TPLEYACVGL
SEEDAVKQHG ADGVEVFHGY YKPTEFFIPQ KSVRYCYLKA VAERTGDQRV YGLHYLGPVA
GEVIQGFAAA LKSGLTINTL INTVGIHPTT AEEFTRLSIT KRSGLDPTPA SCCS
//
