ID A0A0R3PJM9_ANGCS Unreviewed; 699 AA.
AC A0A0R3PJM9;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 33.
DE SubName: Full=Calpain catalytic domain-containing protein {ECO:0000313|WBParaSite:ACOC_0000468601-mRNA-1};
GN ORFNames=ACOC_LOCUS4687 {ECO:0000313|EMBL:VDM56272.1};
OS Angiostrongylus costaricensis (Nematode worm).
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Strongyloidea; Metastrongylidae;
OC Angiostrongylus.
OX NCBI_TaxID=334426 {ECO:0000313|Proteomes:UP000050601, ECO:0000313|WBParaSite:ACOC_0000468601-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:ACOC_0000468601-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM56272.1, ECO:0000313|Proteomes:UP000267027}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Costa Rica {ECO:0000313|EMBL:VDM56272.1,
RC ECO:0000313|Proteomes:UP000267027};
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
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DR EMBL; UYYA01003825; VDM56272.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0R3PJM9; -.
DR STRING; 334426.A0A0R3PJM9; -.
DR WBParaSite; ACOC_0000468601-mRNA-1; ACOC_0000468601-mRNA-1; ACOC_0000468601.
DR OMA; LYMHSAS; -.
DR Proteomes; UP000050601; Unplaced.
DR Proteomes; UP000267027; Unassembled WGS sequence.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR CDD; cd00214; Calpain_III; 1.
DR CDD; cd00044; CysPc; 1.
DR Gene3D; 2.60.120.380; -; 1.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR InterPro; IPR033883; C2_III.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR000169; Pept_cys_AS.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR10183; CALPAIN; 1.
DR PANTHER; PTHR10183:SF379; CALPAIN-A-RELATED; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF00648; Peptidase_C2; 2.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
DR PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239};
KW Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Reference proteome {ECO:0000313|Proteomes:UP000267027};
KW Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW ProRule:PRU00239}.
FT DOMAIN 276..532
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT REGION 235..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT ACT_SITE 331
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 448
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 472
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 699 AA; 76145 MW; C1BB84D37CB216DC CRC64;
MGDDEIMRKV EVKPDEFSGL IGNIAGNFIR DRVGGPGGDI LAGLADNVLG GGGGSGYNDG
GFGGGGYNDG GFGGGGRGQG GGGGGFNLND IGGIINSISG SGGGGGGRGG DIGSIIGGIG
SLIGGGGGGG QYGGGGKWKI CELIYLVLHY YVIMVEGGNI NPNRLNGGMV NIIGNLIGEA
AHRFLGVDPA TGRIIGAVAG NVIMGLGGKD NSLGNIGKVI LDNIISGKFR RDVDPFVRPE
PRPDRGGTGP SPIQPIPSHE PLDFYAERDR CLEKRLFEDP HFPAQDSSLF YSRSPPKRID
WLRPGEIVRE PQLITEGHSR FDVIQGELGD CWLLAAAANL TLKDELFYRV VPPDQSFTEN
YAGIFHFQFW QYGKWVDVVI DDRLPTSNGE LLYMHSKSHN EFWSALLEKA YAKLYGSYEA
LKGGTTSEAL EDMTGDPYIS SKVMDKGHAY SITGMRIVNG PNGQVCLMRI RNPWGNEQEW
NGPWSDNSYE WRSVPDNVKE EMGLRFDHDG EFWMSFEDFM RNFEKMEICN LGPDVMDEVY
QMTGVRAASN TWSANTHDGA WIRNQTAGGC RNYINTFASN PQYRVQLTDS DPDDDDELCT
VIFAVMQKYR RNLKAQGLDN VPIGFAVYDA GNISGRLSKQ FFQANKSSMR SAAFINLREM
TGRFRVPPGN YVVVPSTFEP NEEAEFMLRV YTNGFIESE
//