ID A0A0R3Q5T8_9BILA Unreviewed; 568 AA.
AC A0A0R3Q5T8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=RING-type E3 ubiquitin transferase BRCA1 {ECO:0000256|ARBA:ARBA00031556};
OS Brugia timori.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX NCBI_TaxID=42155 {ECO:0000313|Proteomes:UP000050602, ECO:0000313|WBParaSite:BTMF_0000168301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:BTMF_0000168301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; A0A0R3Q5T8; -.
DR STRING; 42155.A0A0R3Q5T8; -.
DR WBParaSite; BTMF_0000168301-mRNA-1; BTMF_0000168301-mRNA-1; BTMF_0000168301.
DR Proteomes; UP000050602; Unplaced.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006281; P:DNA repair; IEA:InterPro.
DR Gene3D; 3.40.50.10190; BRCT domain; 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR031099; BRCA1-associated.
DR InterPro; IPR001357; BRCT_dom.
DR InterPro; IPR036420; BRCT_dom_sf.
DR InterPro; IPR018957; Znf_C3HC4_RING-type.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR InterPro; IPR017907; Znf_RING_CS.
DR PANTHER; PTHR13763:SF0; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN; 1.
DR PANTHER; PTHR13763; BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN BRCA1; 1.
DR Pfam; PF00097; zf-C3HC4; 1.
DR SUPFAM; SSF52113; BRCT domain; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50172; BRCT; 2.
DR PROSITE; PS00518; ZF_RING_1; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 4: Predicted;
KW Acetylation {ECO:0000256|ARBA:ARBA00022990};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 5..34
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT DOMAIN 392..454
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT DOMAIN 473..526
FT /note="BRCT"
FT /evidence="ECO:0000259|PROSITE:PS50172"
FT REGION 107..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 568 AA; 65184 MW; 67785E5DE9DA534E CRC64;
LRDPIMTTCN HAFCRVCLFE CFKRLSRMRC PICNMTLNKR SCASCPLLSS LLDKYLPLAK
AFKKDIMTTG FAKEDDFMES QVPMTQLASA PLQISQNQSR KLLRMESKSA KRRIAHSKHR
PEKKQRNDEI HYPNLVIETV ANTCAGTSTV KHTSCSSEST IIGYNASRLL FRQLQMNSEE
FNIGQKESEN VRIRNNGKEH RNRLISMEDA TYSPLYVEKL DLNASAIHDE NIEDSSANKT
DASVQMEMIV NSVFEASESQ SRIEVLIKCM PWIPNFLHLD REELINAVCH YNEELCNENN
HSKNGSDLVL ESDEEREVAV PINTSYTIDC CHSDAQENKN RNNEQNTVSL LKDKQCYKEY
NEVCHSMMVS GASKLSDQSL LREFLDNFSS FKLSTSMDRT CTHLVIFNAD GLVCEFWTVK
LIYALVNHCT IVSYSWLENC LNQKTILPTH DFEILLKIDE TLISITAQRA LTDPSTLFDG
YKFYVPQTFF NTQLIARDVF LEIVELSGGE IVSHVWELPS ERSYIIFAPD CFNQDAARRF
VVDRFRKIVS KRSVKNQVVI CCSLQYHQ
//
