ID   A0A0R3Q7B0_9BILA        Unreviewed;       500 AA.
AC   A0A0R3Q7B0;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 29.
DE   SubName: Full=Calpain catalytic domain-containing protein {ECO:0000313|WBParaSite:BTMF_0000221401-mRNA-1};
OS   Brugia timori.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=42155 {ECO:0000313|Proteomes:UP000050602, ECO:0000313|WBParaSite:BTMF_0000221401-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BTMF_0000221401-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C2 family.
CC       {ECO:0000256|ARBA:ARBA00007623}.
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DR   AlphaFoldDB; A0A0R3Q7B0; -.
DR   STRING; 42155.A0A0R3Q7B0; -.
DR   WBParaSite; BTMF_0000221401-mRNA-1; BTMF_0000221401-mRNA-1; BTMF_0000221401.
DR   Proteomes; UP000050602; Unplaced.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00044; CysPc; 1.
DR   Gene3D; 2.60.120.380; -; 1.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   InterPro; IPR022684; Calpain_cysteine_protease.
DR   InterPro; IPR022682; Calpain_domain_III.
DR   InterPro; IPR036213; Calpain_III_sf.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR000169; Pept_cys_AS.
DR   InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR   PANTHER; PTHR10183; CALPAIN; 1.
DR   PANTHER; PTHR10183:SF379; CALPAIN-A-RELATED; 1.
DR   Pfam; PF01067; Calpain_III; 1.
DR   Pfam; PF00648; Peptidase_C2; 1.
DR   PRINTS; PR00704; CALPAIN.
DR   SMART; SM00230; CysPc; 1.
DR   SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 1.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   PROSITE; PS50203; CALPAIN_CAT; 1.
DR   PROSITE; PS00139; THIOL_PROTEASE_CYS; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00239};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU00239};
KW   Thiol protease {ECO:0000256|ARBA:ARBA00022807, ECO:0000256|PROSITE-
KW   ProRule:PRU00239}.
FT   DOMAIN          54..349
FT                   /note="Calpain catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50203"
FT   ACT_SITE        109
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        265
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        289
FT                   /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU00239"
SQ   SEQUENCE   500 AA;  57736 MW;  64A1F3E7C09E8CF8 CRC64;
     LDNIISGKFH RKFQVDPYIP REPRLIPRPP SPSRRSEALD FYKERDRCLQ SNTLFEDPEF
     PADDSSLFYS RRPPKYIEWL RPGEIVREPM LISEGQTRFD VIQGELGDCW LMAGAASLTL
     RDELFYRVVP PDQSFTENYA GIFHFQFWHY GNWVDVVIDD RLPTSGGKLL YMHSREHNEF
     WSALIEKAYA KLYGNYETLK GGTTSEALED MTGGLTEFID LKESPPNLLQ MMFRGFEMGS
     LFGCSIEASP MEFEARTQQG LVKGHAYSIT GMRLIETSQG KIPLLRIRNP WGNEQEWNGD
     WSDDSELWDY VSSQQKKDMN LVLAHDGEFW MSFDDFMRYF NKMEICNLGP DVMDEVREMT
     GVSMEDAGYG RWNTRCHLGA WIGDTAGGCR NYLGMLDASQ KDEERLSDNY IQLLTVRMEQ
     RDKKRLFRRG CILSTVINFN TFANNSQFAM TLSNPNPDDE DGLCTIIIAV LQKNRREMKP
     QGLENLAIGF SVYKVISKLM
//