ID   A0A0R3QXU7_9BILA        Unreviewed;       280 AA.
AC   A0A0R3QXU7;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 17.
DE   SubName: Full=TPP_enzyme_N domain-containing protein {ECO:0000313|WBParaSite:BTMF_0001256901-mRNA-1};
GN   ORFNames=BTMF_LOCUS10583 {ECO:0000313|EMBL:VDO36051.1};
OS   Brugia timori.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Brugia.
OX   NCBI_TaxID=42155 {ECO:0000313|Proteomes:UP000050602, ECO:0000313|WBParaSite:BTMF_0001256901-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:BTMF_0001256901-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDO36051.1, ECO:0000313|Proteomes:UP000280834}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=thiamine diphosphate; Xref=ChEBI:CHEBI:58937;
CC         Evidence={ECO:0000256|ARBA:ARBA00001964};
CC   -!- SIMILARITY: Belongs to the TPP enzyme family.
CC       {ECO:0000256|ARBA:ARBA00007812}.
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DR   EMBL; UZAG01017688; VDO36051.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R3QXU7; -.
DR   STRING; 42155.A0A0R3QXU7; -.
DR   WBParaSite; BTMF_0001256901-mRNA-1; BTMF_0001256901-mRNA-1; BTMF_0001256901.
DR   Proteomes; UP000050602; Unplaced.
DR   Proteomes; UP000280834; Unassembled WGS sequence.
DR   GO; GO:0030976; F:thiamine pyrophosphate binding; IEA:InterPro.
DR   CDD; cd07035; TPP_PYR_POX_like; 1.
DR   Gene3D; 3.40.50.970; -; 1.
DR   InterPro; IPR029061; THDP-binding.
DR   InterPro; IPR012001; Thiamin_PyroP_enz_TPP-bd_dom.
DR   InterPro; IPR045229; TPP_enz.
DR   PANTHER; PTHR18968:SF166; 2-HYDROXYACYL-COA LYASE 2; 1.
DR   PANTHER; PTHR18968; THIAMINE PYROPHOSPHATE ENZYMES; 1.
DR   Pfam; PF02776; TPP_enzyme_N; 1.
DR   SUPFAM; SSF52518; Thiamin diphosphate-binding fold (THDP-binding); 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000280834}.
FT   DOMAIN          59..174
FT                   /note="Thiamine pyrophosphate enzyme N-terminal TPP-
FT                   binding"
FT                   /evidence="ECO:0000259|Pfam:PF02776"
SQ   SEQUENCE   280 AA;  31364 MW;  6E06EF8BC7811CD9 CRC64;
     MCLLSGILFV FIGFLLWLMK IFGIDSIQTF HQILLDLYTR KRSHWILELF QVDEESDHHG
     GELVAAVLKA HNINEIFTLC GGHISPILVA AKNIGIRVYD TRHEVNAVFA ADAVARLRQS
     IGVAVVTAGP GLTNTITAVK NAQLAETAVV IIAGAAPILS RNRGALQDID QISLMRPLCK
     YVARITCIRN IITVLKKAMH IAQSDTPGPV FVEIPIDVLY SYKMVLKEMN IAEARNFKQV
     EIYLLMHFLE LFTQIFKISQ KALHYTLFFV ILECTKFGKN
//