ID   A0A0R3RHH5_9BILA        Unreviewed;      1211 AA.
AC   A0A0R3RHH5;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 33.
DE   SubName: Full=DH domain-containing protein {ECO:0000313|WBParaSite:EEL_0000089801-mRNA-1};
OS   Elaeophora elaphi.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Elaeophora.
OX   NCBI_TaxID=1147741 {ECO:0000313|Proteomes:UP000050640, ECO:0000313|WBParaSite:EEL_0000089801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:EEL_0000089801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
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DR   AlphaFoldDB; A0A0R3RHH5; -.
DR   STRING; 1147741.A0A0R3RHH5; -.
DR   WBParaSite; EEL_0000089801-mRNA-1; EEL_0000089801-mRNA-1; EEL_0000089801.
DR   Proteomes; UP000050640; Unplaced.
DR   GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR   CDD; cd01221; PH_ephexin; 1.
DR   CDD; cd00160; RhoGEF; 1.
DR   CDD; cd11793; SH3_ephexin1_like; 1.
DR   Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 2.30.30.40; SH3 Domains; 1.
DR   InterPro; IPR035899; DBL_dom_sf.
DR   InterPro; IPR000219; DH-domain.
DR   InterPro; IPR047271; Ephexin-like.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR047270; PH_ephexin.
DR   InterPro; IPR036028; SH3-like_dom_sf.
DR   InterPro; IPR001452; SH3_domain.
DR   PANTHER; PTHR12845:SF5; EPHEXIN, ISOFORM D; 1.
DR   PANTHER; PTHR12845; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF00621; RhoGEF; 1.
DR   Pfam; PF00018; SH3_1; 1.
DR   SMART; SM00233; PH; 1.
DR   SMART; SM00325; RhoGEF; 1.
DR   SMART; SM00326; SH3; 1.
DR   SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF50044; SH3-domain; 1.
DR   PROSITE; PS50010; DH_2; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50002; SH3; 1.
PE   4: Predicted;
KW   SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW   ProRule:PRU00192}.
FT   DOMAIN          731..921
FT                   /note="DH"
FT                   /evidence="ECO:0000259|PROSITE:PS50010"
FT   DOMAIN          956..1080
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          1091..1152
FT                   /note="SH3"
FT                   /evidence="ECO:0000259|PROSITE:PS50002"
FT   REGION          41..65
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          154..211
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          651..677
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        160..177
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1211 AA;  137932 MW;  0E2B4EA7B80DCEEC CRC64;
     MIKSNADTTV ALTTPANCGN TDHDDTCDKS MLVQSMYAGS SGSYLTEQER ARRNRPKPPP
     PVKPATLKNK IACRSTQSFF PLASKLKFSI VDGTLSKASS NTVDSSETAK HAEGNDHQTK
     IICSLEDDAT NESDPSFEAM RITDLCIDEI QEAESEPPTL ESAERSSSKT AITNKRASFI
     NEEIKKPKMK PPPPPIHSLQ LPSQSVKGSN KIKTVRRKLN LESVFDAGQD ATEDDNESGE
     LKAHRFERCL DSCHIPTVPS IPPPLPPALS PHDSVNDEMY EEIEQLTYAE EDGQTDKTNA
     PDEQINEVLV QEVNCHKSGQ DECYADEEGK HLNDGINGYS SSNHYGGMLR ASDEEKYCLK
     NKESNMQTNE KAFTTRRPKS ALEFDKLLRI KSDIQLNITK KVGQIKFKVT SASQERQRCK
     RLSSISYTDR EKLKTHNKDN VLAQIDFPLD EQCIYGDVWS SDEDDYTCTT EQNSCKQEQA
     RNQSDEVINS GENISDEPYS MLSEIERELR LRFQAQGNLP DIVLESKRRS MSADPLLHDG
     ASMTARTEGT SAGYRHIKDY NHDNNYRVCC QTKNDKSKST TEGYETIISS TPPSPEHNCL
     PSTSSDYTLK EIDRSIYTAR IIPDPQPLYQ IYMMEQNGQL MYETEEQEVT QPSFSGKSTS
     KMQRTASTAS TDSGRGADCS TTISQLTSNT SMRRDRLIAN SHFASQRSLW CELPEVINAG
     LLESLDEDAK KLQEAYFEVI TSEASYLRSI NILITHFMAA PEMLGSKRPS SVITNEQRKQ
     LFSNIFAVRD CSEKLLSDLE NRLQESVVLS DVCDILCDHF EANFYPYVKY CSNQIYQDRT
     LRKLKSENSS FLACIQRLEG DRLCQGLDMR SFLMLPMQRI TRYPLLMIAI LEHTQQDATN
     YQTAQIALHL ANHIVTCCNE GARHMERTEQ LLEIERRLVY KSSDLRRIPL VSSGRYLVKR
     GSLTCLNEKR AKKLLSTRQQ FQSIYIFLFS DIIMLTKKKM NGTYVCKDYS ARRFVDIEPV
     EINDPKLLQT VSSHIPLKKP HLFICTLMHN AVGKQVELLL NADSETERER WLSALRPPAC
     TNPEEKIYAD WDCPQAVAVH RYSPSQEDEL PLEKGDLINI LRKMPDGWFY GERVRDWYSG
     WFPSSYVQQV LNDHVRAKNY RQRLRVIQAA ADLRFHQKQM KLGTEENARH LMERFRRLNN
     TKNMQNRLKS N
//