ID   A0A0R3RJ20_9BILA        Unreviewed;       787 AA.
AC   A0A0R3RJ20;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   24-JAN-2024, entry version 28.
DE   RecName: Full=ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase {ECO:0000256|ARBA:ARBA00011982};
DE            EC=3.2.2.6 {ECO:0000256|ARBA:ARBA00011982};
OS   Elaeophora elaphi.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Spirurina; Spiruromorpha; Filarioidea; Onchocercidae; Elaeophora.
OX   NCBI_TaxID=1147741 {ECO:0000313|Proteomes:UP000050640, ECO:0000313|WBParaSite:EEL_0000147801-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:EEL_0000147801-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + NAD(+) = ADP-D-ribose + H(+) + nicotinamide;
CC         Xref=Rhea:RHEA:16301, ChEBI:CHEBI:15377, ChEBI:CHEBI:15378,
CC         ChEBI:CHEBI:17154, ChEBI:CHEBI:57540, ChEBI:CHEBI:57967; EC=3.2.2.6;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC       PhysiologicalDirection=left-to-right; Xref=Rhea:RHEA:16302;
CC         Evidence={ECO:0000256|ARBA:ARBA00000404};
CC   -!- SIMILARITY: Belongs to the SARM1 family.
CC       {ECO:0000256|ARBA:ARBA00008291}.
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DR   AlphaFoldDB; A0A0R3RJ20; -.
DR   STRING; 1147741.A0A0R3RJ20; -.
DR   WBParaSite; EEL_0000147801-mRNA-1; EEL_0000147801-mRNA-1; EEL_0000147801.
DR   Proteomes; UP000050640; Unplaced.
DR   GO; GO:0050135; F:NAD(P)+ nucleosidase activity; IEA:UniProtKB-EC.
DR   GO; GO:0061809; F:NAD+ nucleotidase, cyclic ADP-ribose generating; IEA:UniProtKB-EC.
DR   GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR   GO; GO:0045087; P:innate immune response; IEA:UniProtKB-KW.
DR   GO; GO:0019677; P:NAD catabolic process; IEA:UniProt.
DR   GO; GO:0034128; P:negative regulation of MyD88-independent toll-like receptor signaling pathway; IEA:InterPro.
DR   GO; GO:0048678; P:response to axon injury; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd09501; SAM_SARM1-like_repeat1; 1.
DR   Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR   Gene3D; 3.40.50.10140; Toll/interleukin-1 receptor homology (TIR) domain; 1.
DR   Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 2.
DR   InterPro; IPR011989; ARM-like.
DR   InterPro; IPR016024; ARM-type_fold.
DR   InterPro; IPR001660; SAM.
DR   InterPro; IPR013761; SAM/pointed_sf.
DR   InterPro; IPR039184; SARM1.
DR   InterPro; IPR000157; TIR_dom.
DR   InterPro; IPR035897; Toll_tir_struct_dom_sf.
DR   PANTHER; PTHR22998:SF1; NAD(+) HYDROLASE SARM1; 1.
DR   PANTHER; PTHR22998; SARM1; 1.
DR   Pfam; PF00536; SAM_1; 1.
DR   Pfam; PF07647; SAM_2; 1.
DR   Pfam; PF13676; TIR_2; 1.
DR   SMART; SM00454; SAM; 2.
DR   SMART; SM00255; TIR; 1.
DR   SUPFAM; SSF48371; ARM repeat; 1.
DR   SUPFAM; SSF47769; SAM/Pointed domain; 2.
DR   SUPFAM; SSF52200; Toll/Interleukin receptor TIR domain; 1.
DR   PROSITE; PS50105; SAM_DOMAIN; 1.
DR   PROSITE; PS50104; TIR; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Immunity {ECO:0000256|ARBA:ARBA00022588};
KW   Innate immunity {ECO:0000256|ARBA:ARBA00022588};
KW   NAD {ECO:0000256|ARBA:ARBA00023027};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT   DOMAIN          430..494
FT                   /note="SAM"
FT                   /evidence="ECO:0000259|PROSITE:PS50105"
FT   DOMAIN          573..717
FT                   /note="TIR"
FT                   /evidence="ECO:0000259|PROSITE:PS50104"
SQ   SEQUENCE   787 AA;  89577 MW;  CDB4B575E250863B CRC64;
     MQLRFESEYR RFKSEGSSAG VCSLPAPEMD VTIDDLSPIA DPRSSSPSRL SLFQVDTVTN
     GPLTKHSHTE QVMMMHTLKT KLSKYQNFID KAFEHIAQGS DEQIIEGCTI VAKVMTKAWM
     FPKISHDLSY ALCDYLRDQN YFDSLIMNFI KAQTCEPVRL ACGRVLEECL SLNNREYVVN
     KSYLKKLVAT AEKLNKNPEQ QRMSLSIMES LFKHSTNMLS FRLIEYGVLD HILLTCKRAT
     DTPITLRHAA LALANLSLYS CSEAKKKIIQ KKVPDWLFLL ASQPDDITRY YACLAICMLG
     STKEMEAAVN KSGTLALVEP FLLAHQAITF AGDHYKHSQG RPKEWLERLL PMLKSKCREA
     RSIAAFHFTM EATIKKDQQK LEVFQEIGAI AALKEIASSP DEVAAKFASE ALTVIGEEVP
     YKLTQQVPCW TIADVQYWVK KIGFESYADA FAKHMVDGDL LLLLTEKELE QDLQMSSALL
     RKRFIRELES LKIAADYGSV DESQLDQFLM SLSPELSVYT YQMLGMGLNR SLLPSLTDEM
     MKTVCGMHNP IHRLKLRQAF KHIDDIEVAI LSKQIDVFIS YRRSTGNQLA SLIKVLLQLR
     GYKVFIDVDK LYAGKFDSSL LKNIQAAKHF ILVLTPNSLD RLFNDHNCED WIHKELRCAF
     DHHKNVIPIF DQHFDFPADT DLPADIRHIT RYNGVRWVHD YQEACMDKVE RFIKGELNRT
     PSIGQQQIIT VSFVQTSVGS SASSGTQQRK VSARWSIAKT TQKCSVTRQQ HSEMSNNHCM
     VIFLEIP
//