ID A0A0R3SAP6_HYMDI Unreviewed; 546 AA.
AC A0A0R3SAP6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 32.
DE SubName: Full=Lactamase_B domain-containing protein {ECO:0000313|WBParaSite:HDID_0000144501-mRNA-1};
GN ORFNames=HDID_LOCUS1446 {ECO:0000313|EMBL:VDL18907.1};
OS Hymenolepis diminuta (Rat tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000144501-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HDID_0000144501-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL18907.1, ECO:0000313|Proteomes:UP000274504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SUBUNIT: Homodimer. {ECO:0000256|ARBA:ARBA00011738}.
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DR EMBL; UYSG01000267; VDL18907.1; -; Genomic_DNA.
DR STRING; 6216.A0A0R3SAP6; -.
DR WBParaSite; HDID_0000144501-mRNA-1; HDID_0000144501-mRNA-1; HDID_0000144501.
DR Proteomes; UP000046397; Unplaced.
DR Proteomes; UP000274504; Unassembled WGS sequence.
DR GO; GO:0005840; C:ribosome; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0016891; F:RNA endonuclease activity, producing 5'-phosphomonoesters; IEA:InterPro.
DR GO; GO:0003735; F:structural constituent of ribosome; IEA:InterPro.
DR GO; GO:0006412; P:translation; IEA:InterPro.
DR GO; GO:0008033; P:tRNA processing; IEA:UniProtKB-KW.
DR CDD; cd07717; RNaseZ_ZiPD-like_MBL-fold; 1.
DR Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR HAMAP; MF_01818; RNase_Z_BN; 1.
DR InterPro; IPR001279; Metallo-B-lactamas.
DR InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR InterPro; IPR023611; Ribosomal_mS23_dom.
DR InterPro; IPR013471; RNase_Z/BN.
DR PANTHER; PTHR46018; ZINC PHOSPHODIESTERASE ELAC PROTEIN 1; 1.
DR PANTHER; PTHR46018:SF2; ZINC PHOSPHODIESTERASE ELAC PROTEIN 1; 1.
DR Pfam; PF00753; Lactamase_B; 1.
DR Pfam; PF10484; MRP-S23; 1.
DR SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE 3: Inferred from homology;
KW Endonuclease {ECO:0000256|ARBA:ARBA00022759};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW Reference proteome {ECO:0000313|Proteomes:UP000274504};
KW tRNA processing {ECO:0000256|ARBA:ARBA00022694};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 5..106
FT /note="Small ribosomal subunit protein mS23 conserved"
FT /evidence="ECO:0000259|Pfam:PF10484"
FT DOMAIN 143..187
FT /note="Metallo-beta-lactamase"
FT /evidence="ECO:0000259|Pfam:PF00753"
SQ SEQUENCE 546 AA; 61158 MW; E9F426E650B2AF7D CRC64;
MSSYGSRVHK VASIYRRVNG LLKNGALSSK EKPLWFDVYR AFPPKVEPTF GRPLPTDLQV
REILYPEDVG RVEFLRRFEN ASEDLHNLFS PHDNGTCLSK FIAKGRSMGA DELIFLGTGA
AYPSPHRGAS ASVLRHSSGV QWLFDCGEGT QIQVQRCAAV RAQKITRIFI SHLHGDHVFG
LPGMLATISG MREHVTDPRV VHTIEPDKNP GPPDLDIYGP AGLRRFLRSS ISLSWSLCHL
TYAVHELHPR PDMIDNCYRY WTEIDLDPVR DRRLFFEREG RDIYPDEHGF FRDIVDKENG
VKDDRNDFVI HAFMLNHPVP CVGYLLLEPP PLPTLHPDKA IALGVKPGPL MGKLKAGQSV
TFERDGKQIT VHPSQVLGPQ KRGRRVAILG DSRDSSELRR LLQLLCFESR RSRADKKGEK
SESKNGNSGI WRLDCLVHEA TGHSVEQGDQ SMADKGHSTA RSAAAFASTI GARQLVLNHF
SQRFIDDEVF LTQGKDPANY SKVSSLLEDA KSCKEFEGEV HLSDDFKIIP IVGNVEDGDD
LETDIK
//
