ID A0A0R3SAW1_HYMDI Unreviewed; 4201 AA.
AC A0A0R3SAW1;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=DHC_N1 domain-containing protein {ECO:0000313|WBParaSite:HDID_0000153101-mRNA-1};
OS Hymenolepis diminuta (Rat tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000153101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HDID_0000153101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
CC -!- SIMILARITY: Belongs to the dynein heavy chain family.
CC {ECO:0000256|ARBA:ARBA00008887}.
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DR STRING; 6216.A0A0R3SAW1; -.
DR WBParaSite; HDID_0000153101-mRNA-1; HDID_0000153101-mRNA-1; HDID_0000153101.
DR Proteomes; UP000046397; Unplaced.
DR GO; GO:0005930; C:axoneme; IEA:UniProt.
DR GO; GO:0030286; C:dynein complex; IEA:UniProtKB-KW.
DR GO; GO:0005874; C:microtubule; IEA:UniProtKB-KW.
DR GO; GO:0031514; C:motile cilium; IEA:UniProt.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR Gene3D; 1.10.287.2620; -; 1.
DR Gene3D; 1.10.472.130; -; 1.
DR Gene3D; 1.10.8.1220; -; 1.
DR Gene3D; 1.10.8.710; -; 1.
DR Gene3D; 1.20.1270.280; -; 1.
DR Gene3D; 1.20.58.1120; -; 1.
DR Gene3D; 1.20.920.20; -; 1.
DR Gene3D; 1.20.920.30; -; 1.
DR Gene3D; 3.10.490.20; -; 1.
DR Gene3D; 6.10.140.1060; -; 1.
DR Gene3D; 1.20.140.100; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.20.180.20; Dynein heavy chain, N-terminal domain 2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 5.
DR Gene3D; 1.10.8.720; Region D6 of dynein motor; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR035699; AAA_6.
DR InterPro; IPR035706; AAA_9.
DR InterPro; IPR041658; AAA_lid_11.
DR InterPro; IPR042219; AAA_lid_11_sf.
DR InterPro; IPR026983; DHC_fam.
DR InterPro; IPR041589; DNAH3_AAA_lid_1.
DR InterPro; IPR042222; Dynein_2_N.
DR InterPro; IPR043157; Dynein_AAA1S.
DR InterPro; IPR041466; Dynein_AAA5_ext.
DR InterPro; IPR041228; Dynein_C.
DR InterPro; IPR043160; Dynein_C_barrel.
DR InterPro; IPR024743; Dynein_HC_stalk.
DR InterPro; IPR024317; Dynein_heavy_chain_D4_dom.
DR InterPro; IPR004273; Dynein_heavy_D6_P-loop.
DR InterPro; IPR013602; Dynein_heavy_linker.
DR InterPro; IPR013594; Dynein_heavy_tail.
DR InterPro; IPR042228; Dynein_linker_3.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR45703; DYNEIN HEAVY CHAIN; 1.
DR PANTHER; PTHR45703:SF8; DYNEINS HEAVY CHAIN; 1.
DR Pfam; PF12774; AAA_6; 1.
DR Pfam; PF12775; AAA_7; 1.
DR Pfam; PF12780; AAA_8; 1.
DR Pfam; PF12781; AAA_9; 1.
DR Pfam; PF17857; AAA_lid_1; 1.
DR Pfam; PF18198; AAA_lid_11; 1.
DR Pfam; PF08385; DHC_N1; 2.
DR Pfam; PF08393; DHC_N2; 1.
DR Pfam; PF17852; Dynein_AAA_lid; 1.
DR Pfam; PF18199; Dynein_C; 1.
DR Pfam; PF03028; Dynein_heavy; 1.
DR Pfam; PF12777; MT; 1.
DR SMART; SM00382; AAA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 4.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Dynein {ECO:0000256|ARBA:ARBA00023017};
KW Microtubule {ECO:0000256|ARBA:ARBA00022701};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741}.
FT DOMAIN 1570..1706
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT DOMAIN 2178..2323
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 285..304
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 560..587
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 1279..1306
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2776..2855
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3000..3062
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 4201 AA; 478206 MW; 81B7F0E31182C9B4 CRC64;
LLPIFLSNEK EKSVLGGLPD ELIALTKRLK RKTKKYLEST EILKAEPQES IEKVDFALKV
LDSFIRQFKI TRAKLPEYFA NENIPLISWE LNTRLLFSLL IGTNRRLLKI KEILKSAIDF
SNLERIVICG VMGASLTSDV SKLYEEFTEK FKEFIQNDYD CLDLESVEFK QELEDICAKF
EDYQQRLGSV FCQALSGCST AQHISKVTTS SMLNIFGGLL DCPIIKPMIE PFYGNMLTML
EEELFLVKKI IKQSVVGNYT KSNLDTSRSA KTSKVTTKCP SVISNSGNVG NATPKHSNTP
RSQVTCNKNH PLAPPGCKNM PPVAGHLMWS SEISQRLDAS RSLLDSVEHP FMRSKRADRI
RKIITHFQSK LLENDERVFN SWAQRISETC EEGLNQPLLS PLPDGSLYGV NFDPDLITAL
REVKYLLNLA GTNIPDPALK LYEQRETLRK YKLCLDVLVS KYTYLRTKLS RSESALIATE
LSDIEKLLRK GSTKLRWSDE GAWDHIANTR DATNDLFQRV KKAGDNFGNI QKIISAWTQA
PLFERRDGKA ENQLERNGKF EKRKIEIKEA GEKIENLLEA NHQLFKADTE SRTWKNYVQD
VDNLISTGFV EAIRCSLDYL LSETNKENTE IYPLFEIQMD LKMNVINFVP SLEQGPDTTF
FDICNGILDD IYKQADQIRR IGIATGDLQT YEPLMKENPD LEELRLTFIE RIKTVVQSAQ
EFHNSMECFA YLWTENREEV LKAFLNEKIG ESESDESQGV PSLDQFKEKI DEYENVYNEV
IKLEDTILVE PWFKINAKRF KQSLINCVKR WSLLFKKYLI NFVANSLSDL DNFIKTSDKS
LEEDPAPEDY NRLIEIMICL GAVKSRQAST DAKFEPLKRT VDLLNSYGQE VTPEILSLIE
ELPRRWNNLK KRVVLMKQVV APLQSDEVAK VRKWASEFEA AQFRYREHFL KIPSFQYECK
EPYGVLDKEN VAIHEMEEEL VKLKHQAHLF EVVLPEYRQL SSCRRDLRLL KCVWDWVFLI
RSTIFGWYDT PWRRISVDEM DFTLKQFSVK DLRRLDKEAR AWPVFLGIEA EVRNMMTSLR
AVTELQNPTI RGRHWSQLMA ATGVRFEMND NTTLSDLLGL NLHNYEEEVH TLVDKAVKEA
SMEKILKELD QTWGQMSFEV EQHPRRDLKL FKVSQEAIEV LEENQVQLQN MATSKHIDFF
RDQIADWQKK LTTSDYVIGL WSEVQRTWAY LEAIFLSSED IREQLPEDSE RFDKIDSEFG
KVLEDFEKKG TNIIIATHLS GLAERLERLK DELALCEKAL ADYLDTKRLA FPRFYFISPT
DLLDILANGT EPIKVMPHLS KLFDSIASLD LMSNSKIAIT MKAKDGELVK LSKECSLEGK
VEVWLNRVLD EMRATLLYNL HQCVSNFEEH PRDQWIFNYP AQISLAGCQI GWAAEVNLNF
AQLEEGYENS LKFFNKKQIT QLNALITLLI GDLSPQERQK VMTICTIDVH NRDVVARLIS
EKVTHRGAFS WLSQLRHRWD DTVADCFVNI CDADFRYAYE YLGNTPRLVI TPLTDRCYIT
LTQSLHLTMS GAPAGPAGTG KTETTKDLGR ALGIMVYVFN CSEQMDYKSV GNIYKGLAQS
GSWGCFDEFN RISVDVLSVV AVQVKCIQDA IKDKCVKFSF LGEEISLNSA VGIFITMNPG
YAGRTELPEN LKALFRPCAM VVPDFELICE IMLVAEGFTE ARLLARKFIT LYGLTRELLS
KQDHYDWGLR AIKSVLVVAG SLKRGDPTRP EKEVLMRALR DFNIPKIATD DMPVFMGLIT
DLFPAMDVPR KRDLAFEEEV RKAAIDLKLQ PEDNFILKTV QLQELFAVRH SVFILGNAGT
GKSMIWRALF RTNQNLKKKP VAVDLDPKAV TNDELFGIIN PATREWKDGL FSVVMRDLSR
LTHEGPKWII LDGDIDPMWI ESLNTVMDDN KVLTLASNER IPLTPTMRLL FEISHLKTAT
PATVSRAGIL YVNPQDLGWG PYVYSWLAAR DNRSEQANLS ILFETYIPVC LEALRTRFKS
AVPLVELGHV QTLCHLLEVH LTPTNTPPET PKEVFESIFV FCAIWAFGGA LIQDQIVDYR
AAFSKWWMEE FKAVKFPTTT SGGTVFDFYI DPVSKKFEPW CKKVEQFILD ANEPLQTALV
STPETTRVRY FLDLLVAARY PVMLVGAAGT GKTVLIQDLL RSLGEDFLVV NVPLNYYTTS
EMLQRVLEKP LEKKAGRSYG PPGKKRLVYF IDDLNMPEVD AYFTVQPHTL IRQHIDHSHW
YDRTKLTLKE IVNAQYVTCM NPTAGSFTID SRLQRHFAIF NISFPGREAV HSIYNSILSQ
HLELPTAGFS SVVQRLASSI TDLAIDFHAR VTSTFLPTAV KFHYVFNLRD LTNVFQGLLF
SKDECLKTPI DLLRLWIHET ERVYADKLID ATDQTAFKTL LRQFVVKQFT EITAEEDVIF
KEPLLYCHFI QGFGDPRYLP VESKTNLAKL LNDALENYNE MNATMNLVLF EDAIQHILRI
DRILESPRGN ALLVGIGGSG KQSLSRLAAF ISSLEVFQTV AKKGYSISDL KGDLAVLYRK
AGLKNIGTVF LLTDAQILDE KFLVVINDLL ASGDIPDLFS DDEMEEIISA VQSETKAAGI
LDTRENCWQF FINKVRRTLK VVLCFSPVGP KLRIRARRFP ALVNCTSIDW FHEWPEEALL
SVAKRFISEI ELLDPSLHEP ISIFISHVHK TVNDVSKDYL TYDRRYNYTT PKSFLEQIHL
YENMLNKRDQ EIKGKIVRLE NGLQKLESTA QQVDDLKAKL ATQEVELTQK NEDANKLLEI
VSAETAKVVA EKAVADEEEK KVAKIRAEVS AKQRECEADL AKAEPALMAA QEALNTLNKN
NLTEMKSFGT PPAAVVKVVA AVSCLLAPQG KVPKDRSWKA AKAGMMGKID QFLDNLINYD
KENMHESSLK AVAEYLKDPE FDPNFVRSKS LAAAGLCSWV INIVKFHEVF CVVKPKRDAL
DEANKELQSA TDALNGIRDK IAKLEAKLTE LTANFENAKA AKQKCQDEAD NTKKTIDLAN
RLVGGLASEK VRWSQQIEEH KVQASCLPGD VLITAAFLSY LGYFTKKYRS ELLEKIWMPY
LSSLQPTIPM TDNLDPLTLL VDDALVAKWN NEGLPSDQFS IENAAILTAA ERWPLLVDPQ
LQGIKWIKTR YGEDLKILHL GQKGYLDVIE RAVSNGEIVL IENIDLVIDP VLEPLIGRNT
IKRGTAIRLG GKEIDYNSDF KLILQTKLAN PHYAPELQAQ TTLINFTVTR EGLEDQLLAN
IVRKERPDLE TLKSDLTRQQ NEFKITLKAL EDALLAKLSE AEGNFLGNYA LVENLENNKR
TAAEIQGKVE QAKITEEEIN SAREIYRPAC ERAAMLYFTI SDLNKINPIY QFSLKAFGFV
FDTAMNRANP SDDVKTRVTN IINSVTYSVY IYTSRGLFEK DKLLFTAQIA FQVCQARGEI
NSQELDYLLR FPITPNVTSP VDFITNIGWG AIKSLTTLET FNNLDSDIEG SAKRWKKIVD
SEKPENERLP QDWKNKTHLQ RLCILRALRP DRMLYAIGNF VSSNLGKVYI EGSSLPFAES
FKESGPATPI FFILSPGVDP LKDVEALGRH LGFTSDKKNF HNISLGQGQE VVAEEAMQLS
AREGHWIILQ NVHLVAKWLP VFEKRLEELM EGAHTNYRVF ISAEPASSPE FHVIPQGVLE
NSIKIVNEPP TGMQANIHKA LGNFTQETLE MCTKENEFKM ILFTLCYFHA VVCERRKFGP
QGWNRIYPFN NGDLTISIDV LYNYLEVNND VPWEGLRYLF GDIMYGGHIT DDWDRRLCKT
YLEEYLATNM LDGDHLLAPG FKVPPNSDLI GYHKYVDENL PPESPYLYGM HPNAEIDTLT
VDSEKLFRRL LEMMPREGTE GDEAGDSTEG KVQSILDDIL ERLPEPFNTQ DIQSQVPPEE
RTPFVVVAFQ ECDRMNVLIR EISRSLKELS LGLKGELTIS AEMDALQNAL FFDTVPNSWA
ARAYPSLYSL GLWYADLIAR ARELEIWVAD FSSLPSAIWL GGLFNPQSLL TAIMQQMSRK
NEWPLDRMML SVEVTRKLTR EELTGPPRDG AYIHSLCMEG ARWDVQAGVL AEAKPKELVA
PLPIVFIKAV PVDKADTRGT YACPVYKTKS RGPTYVWTFN VKTKAKPAKW VLGGVAIILQ
V
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