ID A0A0R3SB32_HYMDI Unreviewed; 2530 AA.
AC A0A0R3SB32;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 08-JUN-2016, sequence version 2.
DT 27-MAR-2024, entry version 38.
DE RecName: Full=Serine/threonine-protein kinase ATR {ECO:0000256|ARBA:ARBA00024420};
DE EC=2.7.11.1 {ECO:0000256|ARBA:ARBA00012513};
GN ORFNames=HDID_LOCUS1627 {ECO:0000313|EMBL:VDL19088.1};
OS Hymenolepis diminuta (Rat tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000162901-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HDID_0000162901-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (APR-2016) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL19088.1, ECO:0000313|Proteomes:UP000274504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mn(2+); Xref=ChEBI:CHEBI:29035;
CC Evidence={ECO:0000256|ARBA:ARBA00001936};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. ATM subfamily.
CC {ECO:0000256|ARBA:ARBA00010769}.
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DR EMBL; UYSG01000317; VDL19088.1; -; Genomic_DNA.
DR STRING; 6216.A0A0R3SB32; -.
DR WBParaSite; HDID_0000162901-mRNA-1; HDID_0000162901-mRNA-1; HDID_0000162901.
DR Proteomes; UP000046397; Unplaced.
DR Proteomes; UP000274504; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0006281; P:DNA repair; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00892; PIKKc_ATR; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR003152; FATC_dom.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR003151; PIK-rel_kinase_FAT.
DR InterPro; IPR014009; PIK_FAT.
DR InterPro; IPR012993; UME.
DR PANTHER; PTHR11139; ATAXIA TELANGIECTASIA MUTATED ATM -RELATED; 1.
DR PANTHER; PTHR11139:SF128; SERINE_THREONINE-PROTEIN KINASE ATR; 1.
DR Pfam; PF02259; FAT; 1.
DR Pfam; PF02260; FATC; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF08064; UME; 1.
DR SMART; SM01343; FATC; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SMART; SM00802; UME; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS51189; FAT; 1.
DR PROSITE; PS51190; FATC; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW DNA damage {ECO:0000256|ARBA:ARBA00023204};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Manganese {ECO:0000256|ARBA:ARBA00023211};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000274504};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1496..2177
FT /note="FAT"
FT /evidence="ECO:0000259|PROSITE:PS51189"
FT DOMAIN 2173..2483
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
FT DOMAIN 2498..2530
FT /note="FATC"
FT /evidence="ECO:0000259|PROSITE:PS51190"
SQ SEQUENCE 2530 AA; 285397 MW; 67E1768683851A6A CRC64;
MSSVFSDSYN DFILSIAYLL VQHLSIHAEK HEADPSRVFR LALPNPIEQK QFKIGDIFIS
LQPQNFEISS VGDAYNFMFI ICQVISACIS RFLAMRPTLI DRVFDILIEI IDFADLNGKL
ECIRAVSCCL DALSCSEALY SSSLLSKVFQ LSSSSLKCLA FLSESKHKSI ALFYELKMPE
QLVLSCCDLI SHVCQLISMT QNNWNGLSSD EFAEMVGTYK STFIGISECK LPQNRVLILA
LMKFFCRGSI SFPEISQTHI QLCEGLIQVQ KFRENMLFQG DEKFPSCADR EAFRCQVIEF
FAVAFNRIGV TTLQLHLNSF LRTIPDWASL SLIISACVRC IDLDQCWYDP VIVTLPSIIP
SLITAFIPTI QDVDSNYLDL VGRINLFSDL LASLPCWDLL RGLDFNDLKN LWKFFENLST
LSDRNTHLLA ISLRASLLFL VFWKSREFEP SDMNFLPVLL NKVLVQGNLY WIEDAPILDR
CAWSESIVPL FETILSAFSD AELRDRTILR GLVNLLNMAI CVSWSPAVKD KCRRCSKCIL
SATALGSQTL KMTVVEKLLN LMDENLTLQI ELALHAVQHL SWDVCSGEVI KNFVLTVLSW
IGKVESPFVA LLSDIFVELC GRLLPENASR WVSLHRLILE HIALQLSEPP SENTALFYEA
FLKIIGGMGC QLAIGVKSCD PFVKRLQNTS ELDDSFGRRT KRPRKSGVPN ADVSILGLPN
AIEETSLESV EDLSNEFGLK TDALLREARY QISKVVLEHS TPCIVKTLDA VSRIFQVEKS
AVLKELCTPL FTHLVVKGTY ESELQVNNLV DQMEGSENED RIFKIVRLCI LPDVLVYIFT
NLSEEQRTAS LNFLESFFGT SIENVARMND ISRLLHHFVL NLYPHRDEAL AGLCWLNSIK
LKYRGPKPLN GLLLQQQPLS NQNQIEPELS YVSSEQLSVF LQKNLGGILA FFDSRLIDDT
YPLEERRRCL LSLSFFMDLV GGQPVSRTRA KFIATLKLCL RYKFVEPKSV VQLWSMFLKM
LEPESLVELL PDIAANLINL LPIAPDYVKK ALGHIFITRR DQIGNSLKQV FFLPELSSLV
DYQSVIKEAC PWLSLCASSD AYSDPHELEL PPPNGFVDLL TAWLGGLEHS SRPVRRYTLA
SLVDAVVANS NNGYRHHHHR CGRLMQLSRL VVRALKVHRP TAIASSTQEG VPDGSCPYMS
IRHLLSRLIA CLLTSLTRDA DPEIRLLYSK WLGANSTALA LQELLRLFQI PRSVDGQDKI
EGADWLLLGE ELWSKFSTNI RDLLTPLFSS KYVVEALNEG QAIDPPIFSR DDCSSYGHWL
RVTNPMMHKL FKYCGPVINS DSEFARYILD PIALQVIIDG NQNGASKVQT EIISLLETVA
DSNRSDRCTD KLPTDFLFYN DINPALNSPS AFSSATWKSW YPLAAQTIFS LLDFLSSWHR
SRSADYTVVV AAVARSSDRR SDGAFKPTED QKTRLLQLHM AVTRMSDFLN TLSHSIRARA
SRQIGGLART LRNWEFAFAA DEIARKAFFV TGFIDRLEAP QGPLIGDAAK ESLIGMIETL
SSLHDTDGVM GVLAQMQHTG IHPSPKAIIS LSKTDALKSC LLRALQLENE ESLEMACATY
EHSIASSKPQ NARDWGLHAA LFRCYLPDPA SLPSLVTRSG ILLSAAWNEK PTERSAVENA
AWFRQLNEIR AEAVIRMGNW EELDKILVSE SSEASWSLGL GKVFLAIKKC TNEIQRNNYL
TEFMNDLRQS QMNVLATSAL EGASGYLRAS EPLVNLSLLT DIEEILKVSD QLNKEVAAVC
ELGLTRSQKN SELLINNMLS WLNARIQHAK PTYHTLEPVL AMRHSAIELI ASRIQPAMNS
SNIAEQLKSH QLQLLESALG ENWLQRARLA RRSGQFTTAY TCVLKAESQG CIGAMIEYAK
LLWQGNKQEA ALDSLNKGLS ALAATSTNSV GIPQGLAQSL TMHPPSSKNC KSLDSSFVLE
ALLLHARYCV ETSHLDFDRT RRLYTDICEA FPGCEKAHFR LAHYVDEAHV KSGSHHDVLL
KIALESYSKA LASGSQYIFQ SMPRFLSLWL DYGSKVAKIQ QRQSQPITHS SSFNRKSSGL
KPSETSMIST FDEVQELVRK GIDKIPKYQF YTAIGQILSR VCHEHPAVIN LLIDLIVHIL
NEYPQQTVWF VISLHEATVA QRHERFQQIC SKINALNPQR FRYIKDDMRK DSRLMDMNSI
INRFLLRNPQ TRHRGLGIRT YAVIPLREHG GLIEWVSNTQ PFRNILTTLY AEAGRPLNWI
SMNRYAPLLE DPLPVKREKF LNKLLPMYPL VFYRWFIGVF PNPSEWYEAR ETFIKTCAVM
SMVGYVLGLG DRHTENILFD CTTGGLVHVD FSCVFNTGLT LPWPERVPFR LTRSLVHAMG
PTGYEGTFRR CAEVTMRLLR REIDPLMAVF RPLYFDSLVE KSSDISANVD ARKVRKTGHV
EAAPIESKLT RAAIEKLSGM EDRLRGKITE HDEFSKLLPM SVEGQVDVLI KEATSVDRLC
QMYKGWMPFL
//
