ID A0A0R3SBC6_HYMDI Unreviewed; 751 AA.
AC A0A0R3SBC6;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 36.
DE SubName: Full=Frizzled-4 {ECO:0000313|WBParaSite:HDID_0000176101-mRNA-1};
GN ORFNames=HDID_LOCUS1762 {ECO:0000313|EMBL:VDL19223.1},
GN WMSIL1_LOCUS4260 {ECO:0000313|EMBL:VUZ44060.1};
OS Hymenolepis diminuta (Rat tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Hymenolepididae; Hymenolepis.
OX NCBI_TaxID=6216 {ECO:0000313|Proteomes:UP000046397, ECO:0000313|WBParaSite:HDID_0000176101-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:HDID_0000176101-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDL19223.1, ECO:0000313|Proteomes:UP000274504}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:VUZ44060.1, ECO:0000313|Proteomes:UP000321570}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=WMS-il1 {ECO:0000313|EMBL:VUZ44060.1,
RC ECO:0000313|Proteomes:UP000321570};
RA Jastrzebski P J., Paukszto L., Jastrzebski P J.;
RL Submitted (JUL-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; UYSG01000360; VDL19223.1; -; Genomic_DNA.
DR EMBL; CABIJS010000122; VUZ44060.1; -; Genomic_DNA.
DR STRING; 6216.A0A0R3SBC6; -.
DR WBParaSite; HDID_0000176101-mRNA-1; HDID_0000176101-mRNA-1; HDID_0000176101.
DR Proteomes; UP000046397; Unplaced.
DR Proteomes; UP000274504; Unassembled WGS sequence.
DR Proteomes; UP000321570; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF99; FRIZZLED-4; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000274504};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..751
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040668212"
FT TRANSMEM 259..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 293..313
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 354..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 395..412
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 432..462
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 483..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..156
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 254..579
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT DISULFID 42..103
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 50..96
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 119..143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 751 AA; 83390 MW; 6DBB270CEE30284C CRC64;
MKGMYLSCIL LLSVTSIASE SEPFHGLKKP PNYHDDDDQA KCTPIREPVC QGLQYEVTIM
PNWVKMTSQE EAAKRMIDYK SLLNINCSHY LKLFLCTIYF PMCTPVLQSS ALKPCKSLCM
HVRSRCEPIM QQFKFSWPTE LTCDDLPEPP DLCIQPPNGY GLDDQKPVLP TASSNMESLQ
RMYPHLQDLF LKRGHGPPNI DSFIQAAVAD GSIPAVSRGS SQVCTGAEFP AVQTSNDTCL
TYCGADLYYR PAGKKFARAW LLGWSVFCVF SSALTFLTFF ADGSRLQYPE RPVLYLAACY
FVIGLGYILQ YSLGPERVIC RSMQTIDSGS EGVTRKYLLT GGQESTLCTV GFLISYYFGM
ASNFWWVMLS LAWYLSTSRK WGHEGVESVS SVFHMFAWAL PAIQAILILI LHKIDADELT
GTCYTGFHSE SALMYGVLLP QAICLVLGLL LLSVGFAAVF RVRRKLKAPT DRERDNRRRL
EKSIAKLGVF VVLYTFPMAC LLASNLYEYL GQSKWRSALR ELNALRPHCL SPRGVAWGLP
DCHPKESPST EAAMLRIFMS FVVGITSGMW VWANKKTLMS WKRAICHGKP RHLPQTVPQT
SQQQLQLPQI QQQRSKFTRN GAYVSSGYGG PLSADGAESE RPDRAFTNDA NTIFSASAVG
YTSSAACQSC HLCPPPPPAP TDLTGGGYSS ASGQSPGLEM YGECFLHQHM SPISRDQCFH
PSNFGSFQSG EGNGVIAPLM HRPQQNNSEC I
//
