ID A0A0R3VVB7_TAEAS Unreviewed; 1305 AA.
AC A0A0R3VVB7;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 29.
DE RecName: Full=Acylamino-acid-releasing enzyme {ECO:0000256|ARBA:ARBA00018421};
DE EC=3.4.19.1 {ECO:0000256|ARBA:ARBA00012917};
GN ORFNames=TASK_LOCUS1325 {ECO:0000313|EMBL:VDK22865.1};
OS Taenia asiatica (Asian tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000132401-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TASK_0000132401-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK22865.1, ECO:0000313|Proteomes:UP000282613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Cleavage of an N-acetyl or N-formyl amino acid from the N-
CC terminus of a polypeptide.; EC=3.4.19.1;
CC Evidence={ECO:0000256|ARBA:ARBA00000721};
CC -!- SUBUNIT: Homotetramer. {ECO:0000256|ARBA:ARBA00011881}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the ku70 family.
CC {ECO:0000256|ARBA:ARBA00005240}.
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DR EMBL; UYRS01000312; VDK22865.1; -; Genomic_DNA.
DR STRING; 60517.A0A0R3VVB7; -.
DR WBParaSite; TASK_0000132401-mRNA-1; TASK_0000132401-mRNA-1; TASK_0000132401.
DR Proteomes; UP000046400; Unplaced.
DR Proteomes; UP000282613; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0008236; F:serine-type peptidase activity; IEA:InterPro.
DR GO; GO:0006310; P:DNA recombination; IEA:UniProtKB-KW.
DR GO; GO:0006303; P:double-strand break repair via nonhomologous end joining; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR CDD; cd00788; KU70; 1.
DR Gene3D; 1.10.1600.10; -; 1.
DR Gene3D; 2.40.290.10; -; 1.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR Gene3D; 4.10.970.10; Ku70, bridge and pillars; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR045550; AARE_N.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR006164; Ku70/Ku80_beta-barrel_dom.
DR InterPro; IPR027388; Ku70_bridge/pillars_dom_sf.
DR InterPro; IPR047087; KU70_core_dom.
DR InterPro; IPR005160; Ku_C.
DR InterPro; IPR005161; Ku_N.
DR InterPro; IPR001375; Peptidase_S9.
DR InterPro; IPR016194; SPOC-like_C_dom_sf.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR42776:SF4; ACYLAMINO-ACID-RELEASING ENZYME; 1.
DR PANTHER; PTHR42776; SERINE PEPTIDASE S9 FAMILY MEMBER; 1.
DR Pfam; PF19283; APEH_N; 1.
DR Pfam; PF02735; Ku; 1.
DR Pfam; PF03730; Ku_C; 1.
DR Pfam; PF03731; Ku_N; 1.
DR Pfam; PF00326; Peptidase_S9; 1.
DR SMART; SM00559; Ku78; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR SUPFAM; SSF82171; DPP6 N-terminal domain-like; 1.
DR SUPFAM; SSF100939; SPOC domain-like; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA damage {ECO:0000256|ARBA:ARBA00022763};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000282613}.
FT DOMAIN 1095..1242
FT /note="Ku"
FT /evidence="ECO:0000259|SMART:SM00559"
SQ SEQUENCE 1305 AA; 144705 MW; 7FDFE4407C833D1A CRC64;
MVIDRGHLRN WASRIFSYFS CLAAPLSVKI RVKQSALGTE KTYSICSKWK QVDSCRNDCL
IMDQEYLISF RDRFEAPQLL YSSSGTVTSF SSCCSHAGKS GTLLWDIEQD HLRAIFVEYA
IPGSMIGDTE AMKASATIPG TFVHLFCLKS GKKLKTIQLP TEKSKSLPAV HGKVCRSGDP
SEPFASCRFC PTNPNKIVYL AECSRTVGGK DSSESATRGI PERSPFILEE NWGEGLSDTS
RPVMFLLDLE TEEVVSTQPI LEKLVSEASH WSFDDPHYTP DGKGIVFVAY DNDPYRLGLK
YCYHRVARLM HWEFETSTLR CLSHDNHAVR WPRFSPDGSK LVWFEMPAGG PHGQCFAMIA
QQWPPNQFKS EVVVPLIAMV KERSDFPGLY LSDGVPERCW TADNKGVVLS TIWGAEKALI
HVSLDSSPLE RISRFPSPLA DVENGGGYGT VTLMDIINNV LVVDVSSPTV PNFLAVAKIS
GESVTKTSWL SLNLTGDEQP IVPYLKGLAW KVLEHAAKTE DTRFGVTRFE SILVYPLLDS
SSLQFSGGSH FKSQEVTWES TRGLIVFPHG GPHSAFTAEW LPLLASYIAA GFACLLVNYR
GSVGYGNSSI YSLPGKCGTI DVADCVQATE EALCELNNPD LPCVLLGGSH GGFLVLHLAG
RHASLYRAVV ARNPVTNLLS MLSTTDIPDW CWTEAGIGLD NVLADPQHPD HLCHACTFAS
NFCPTDPEHL TRLAACSPII YVSSKWSVPI LMCIGAKDQR VPNEQFPAAR DSVIFLIDCT
ATMVSEKLPQ VPVGAATDTG LKLALLFCEK FMQKKALSSP DDMVGLVLMR MNLDVIDAPR
ILAIEKIREM SSKQFVECYG RLLTGESYPI HEALWACQNI FNNAKKSLGY KRIFLLTDDP
DPIGSKTQLK SQAIFKANDL QQSGIEIKLI RIQQADVDFR MDTFYKHLLP PETEIDLPIV
ESSDHLDKLF NWSVLICPCI LTSMNEMLNL IDHSSPLDCR EGLRESKRHR LGRLPLYLVP
MTPAALIGGA IGIEPSGQAP TLAFGVAPYC PVRCVPPPGQ VRVYAKTNEP ITVKRRFYKG
WRNDQHSRGV KADIRNLVMP QDIVRGLRVG NRIVHFGKSE LAGCLRQVAA VGIHILGFKS
LRKLKSWCQL KTAQFLFPEE GMAKGSTLWF TTLLSACLRK QVFAVALYMR HRGMSPHFVA
LVPQAEKMNE CGAQTAGPGF HVLYLPYRED FRRFKLPKHP PAIPEEVEAA KAMVKKMFTN
YHPEAISNPS LQRHHAELEA LALERTDPCV GIDHTRTPPS RAIAS
//
