ID A0A0R3W4C8_TAEAS Unreviewed; 1330 AA.
AC A0A0R3W4C8;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 34.
DE RecName: Full=RNA helicase {ECO:0000256|ARBA:ARBA00012552};
DE EC=3.6.4.13 {ECO:0000256|ARBA:ARBA00012552};
GN ORFNames=TASK_LOCUS4864 {ECO:0000313|EMBL:VDK34128.1};
OS Taenia asiatica (Asian tapeworm).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Taenia.
OX NCBI_TaxID=60517 {ECO:0000313|Proteomes:UP000046400, ECO:0000313|WBParaSite:TASK_0000486301-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TASK_0000486301-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDK34128.1, ECO:0000313|Proteomes:UP000282613}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.13;
CC Evidence={ECO:0000256|ARBA:ARBA00001556};
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- SIMILARITY: Belongs to the DEAD box helicase family. DEAH subfamily.
CC {ECO:0000256|ARBA:ARBA00008792}.
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DR EMBL; UYRS01018376; VDK34128.1; -; Genomic_DNA.
DR STRING; 60517.A0A0R3W4C8; -.
DR WBParaSite; TASK_0000486301-mRNA-1; TASK_0000486301-mRNA-1; TASK_0000486301.
DR Proteomes; UP000046400; Unplaced.
DR Proteomes; UP000282613; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0003725; F:double-stranded RNA binding; IEA:InterPro.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0003724; F:RNA helicase activity; IEA:UniProtKB-EC.
DR CDD; cd19854; DSRM_DHX9_rpt1; 1.
DR CDD; cd19855; DSRM_DHX9_rpt2; 1.
DR CDD; cd18791; SF2_C_RHA; 1.
DR Gene3D; 1.20.120.1080; -; 1.
DR Gene3D; 3.30.160.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR011709; DEAD-box_helicase_OB_fold.
DR InterPro; IPR011545; DEAD/DEAH_box_helicase_dom.
DR InterPro; IPR044445; DHX9_DSRM_1.
DR InterPro; IPR044446; DHX9_DSRM_2.
DR InterPro; IPR002464; DNA/RNA_helicase_DEAH_CS.
DR InterPro; IPR014720; dsRBD_dom.
DR InterPro; IPR048333; HA2_WH.
DR InterPro; IPR007502; Helicase-assoc_dom.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR18934; ATP-DEPENDENT RNA HELICASE; 1.
DR PANTHER; PTHR18934:SF119; ATP-DEPENDENT RNA HELICASE A; 1.
DR Pfam; PF00270; DEAD; 1.
DR Pfam; PF00035; dsrm; 2.
DR Pfam; PF04408; HA2_N; 1.
DR Pfam; PF00271; Helicase_C; 1.
DR Pfam; PF07717; OB_NTP_bind; 1.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00358; DSRM; 2.
DR SMART; SM00847; HA2; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF54768; dsRNA-binding domain-like; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00690; DEAH_ATP_HELICASE; 1.
DR PROSITE; PS50137; DS_RBD; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Helicase {ECO:0000256|ARBA:ARBA00022806};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Reference proteome {ECO:0000313|Proteomes:UP000282613};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW RNA-binding {ECO:0000256|PROSITE-ProRule:PRU00266}.
FT DOMAIN 2..76
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 171..244
FT /note="DRBM"
FT /evidence="ECO:0000259|PROSITE:PS50137"
FT DOMAIN 408..574
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 652..823
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
FT REGION 109..136
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1272..1330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1276..1293
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1309..1330
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1330 AA; 150540 MW; 1517C5A857D64363 CRC64;
MSDVEGIKSF VYTWLHKTQR KVPEYTFQQR PAGRGRSRFI CELRVDGFSY IGVGNSVNKK
DAQTNAARDF SNFLVREGYL KASDLPAIRA EEYKHMTDED RHCATLYPST SSGGAGHPSY
HPPHSQASAT NVPGGGPNDS YINRIMDRIK LEEAEEVDPT ADIHGGWSME NSKARLNEYL
QASRLPPVQI KFTSIGPDHN KSFLAEATVW AKRVNKTLYA RENGSNKTMA SRACCLSLVR
QLFHVGEIEA YNGERKRKRS DELPSLTVKL NPDLENRLTA LLERLHLVPN LSPPVPSPKT
SRSAADSSEE EHNMIMHYQV ADFEPRPRQS AQLVSWCPPI ENWNPWTACN IDEGPEVCAP
ASAALMSLVQ ISQTYKEQYE RRINSRVYEI IREERNSLPV AAFNQQILRT IVRNQVTLIK
GETGCGKTTQ VPQFILDSYL ASGRGAECSV LVTQPRRICA ISLAERVASE RCEVVGVSVG
YSVRFETILP RPYGSILFCT IGTLCRKMEA GIRGVSHIII DEIHERDVNT DFVMILMRDL
VRANPSLRVI LMSATIDTTT FTEYFDNTAT VELEGRTYPV SCFYLEDCIN VTNYVPPPNY
EKNNKKPRME ERLTMETEEN CNLICPPGYP PSVAERMRQI PEKEVPFTLI GSLLEYICRM
DIDGAVLVFL PGWNTISILR KYLQTHPRFS NPNEFLILPL HSQVPREDQR LVFRPAPPGV
RKIVLSTNIA ESSITINDVV FVIDTCLARV KMFTARNNLT SYSTIWASRT NLEQRRGRAG
RVRAGFAYHL CSQARLNRLE HYTTPEILRT PLHELALMIK LLRLGDIQSF LRKALQSPPL
DAVIEAEYTL REMRALDSND ELTPLGHILA RLPIEPRLGR MLVFSCAFRL GGAMALIAAH
SSFGCDVLAM PPDRRRLSWE QIRFAAATNS DHLAMLNAFQ IWSTKRAHDG DQAANYFCDA
RELNAFSLRM IDEAANQIRN ILMGLGFPES VLSDRLINFN DRNCPTFDYV AAMLTNGLYP
NIAYHMEKRK LLTAEGKCAL VHKGSVNCTK NPSFVFPLFT FTEKIRTQAI SCKTLTMITP
IQLLLFGCRR GVWKPKPTDA EGARSDKRGV APEEGVVLLD DWLPFRMRYS TAACIFALRP
ALEALLVRVC LRPDCLEDLS PEDNSVIELT KELCRHTALR GVAAPDEITH LTSVRSNTDR
NRPLLTDSRR QFVSPEMRAT SFDQNEGQSI GSGYREWWDD ESCAPINQVH PFRYHPRAGV
YGTKRDYPWP NQETYIPQDY DGQIGSLQQP AGYYTEPSPR YETPDYGYEP PLSRPPGLQP
WEQPRPPYPY
//
