ID   A0A0R3WKU9_HYDTA        Unreviewed;      1097 AA.
AC   A0A0R3WKU9;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 30.
DE   SubName: Full=Calpain catalytic domain-containing protein {ECO:0000313|WBParaSite:TTAC_0000136601-mRNA-1};
OS   Hydatigena taeniaeformis (Feline tapeworm) (Taenia taeniaeformis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Hydatigera.
OX   NCBI_TaxID=6205 {ECO:0000313|Proteomes:UP000046396, ECO:0000313|WBParaSite:TTAC_0000136601-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TTAC_0000136601-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the peptidase C2 family.
CC       {ECO:0000256|ARBA:ARBA00007623}.
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DR   AlphaFoldDB; A0A0R3WKU9; -.
DR   STRING; 6205.A0A0R3WKU9; -.
DR   WBParaSite; TTAC_0000136601-mRNA-1; TTAC_0000136601-mRNA-1; TTAC_0000136601.
DR   Proteomes; UP000046396; Unplaced.
DR   GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd00044; CysPc; 1.
DR   Gene3D; 2.60.120.380; -; 2.
DR   Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR   Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 1.
DR   InterPro; IPR022682; Calpain_domain_III.
DR   InterPro; IPR022683; Calpain_III.
DR   InterPro; IPR036213; Calpain_III_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR031315; LNS2/PITP.
DR   InterPro; IPR007330; MIT_dom.
DR   InterPro; IPR036181; MIT_dom_sf.
DR   InterPro; IPR038765; Papain-like_cys_pep_sf.
DR   InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR   PANTHER; PTHR46143; CALPAIN-7; 1.
DR   PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR   Pfam; PF01067; Calpain_III; 1.
DR   Pfam; PF04212; MIT; 1.
DR   Pfam; PF00648; Peptidase_C2; 1.
DR   SMART; SM00720; calpain_III; 1.
DR   SMART; SM00230; CysPc; 1.
DR   SMART; SM00775; LNS2; 1.
DR   SMART; SM00745; MIT; 2.
DR   SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR   SUPFAM; SSF54001; Cysteine proteinases; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF116846; MIT domain; 2.
DR   PROSITE; PS50203; CALPAIN_CAT; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU00239}; Protease {ECO:0000256|PROSITE-ProRule:PRU00239};
KW   Thiol protease {ECO:0000256|PROSITE-ProRule:PRU00239}.
FT   DOMAIN          530..813
FT                   /note="Calpain catalytic"
FT                   /evidence="ECO:0000259|PROSITE:PS50203"
FT   ACT_SITE        562
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        731
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
FT   ACT_SITE        751
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00239"
SQ   SEQUENCE   1097 AA;  123829 MW;  A7BEE2C59B6A9B82 CRC64;
     LIYAKETGWE RLGSQITDSN GRLTFQLSEA SRLPVGLHRI QLIPIIGEPD EQAVELTLAI
     VPPNCDVVIC SIDGSFAASL SLMGKDPKVR PGSVDIMRHW YALGYLLIYI SARPDMQHRQ
     VASWLAQHNF PPGLTFFLDG IFTDPLRQKA ILLKSLVEQN QLSVHCAYGS AKDVPIYRSL
     GLQAHQIFAV GKLSRRQALE ATPIREGYTS HFKELMDQKH LSIPATGPLS AAVLRNAAEL
     LHSSAPPSAK STVFFDLPGT VVDVVPMSVP SSPPAHHHEF IKQAQHYENI KDYGLAVFYY
     VEAVQAWLNA KNAGSTNPDI LALARSYTRH AEELVEKRDA MGSIAKVPQQ NMEVERAKCL
     LNEALEADEQ ENSADALNLY SQAIEILLKV RNETSDRAFR EKVERLAKQA LDRAEALKTA
     ARSPSLSKMS AAQKACNRLL IWLDLYFACS HLYLCVVGRR ACIYLAARSG EAGGYTKEEL
     RVLRETSTIN GREYLPFLDA IDSHERFAFA QPFTDQHGLI ALSSKQRSGF VKWVRPSDFL
     NDPTMIIAVS CFPIRQTCVT DCSFVASMAV AAQYERRFKK RLITNIIYPQ KKNGEPVYNP
     CGKYMVKLHL NGVPRKIIID DRLPMGYHDE LLCSFSTNKN ELWVSLLEKA YMKVMGGYDF
     PGSNSNIDLH ALTGWIPERV SIKSSGTNEF DADREFRRLE KRFHRGHCLV TVATGLLTPE
     VEQRSGLVPT HAYALLDMRQ VDQTKLLLLK NPWSRTRWKG NFSDQDTERW TPEMQRKLDY
     DLNSARYVDN GVFWIDYKSL LYFFDVFYIN WNPELFPYTT CVHSEWSASE GPKKDVYSFA
     NNPQYTLEVQ AKSQAPVWVL LTRHITNKND FAHNNEFIGL VVYKDIQSRK VYHPNDPVPL
     KDSVRINSPH CLIQLVQEPG TVTYTLVVSQ YEKNVTIQYT LRAYSTAPMR FSPITDPYTV
     TKTINGEWKG NTAAGCQNYA NFDKNPTFTL VWPNNEVDNQ VLVEVRGPRD FAIGFTWDVV
     SLTNPSPLNS SRSLSTGNYR AEVVFVIGLS RGYTMLELAG LSGGRYKITL ATFEPLQEGP
     FILSVKSTRP LTLTRLQ
//