ID A0A0R3X1U4_HYDTA Unreviewed; 756 AA.
AC A0A0R3X1U4;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 24-JAN-2024, entry version 34.
DE SubName: Full=Frizzled-4 {ECO:0000313|WBParaSite:TTAC_0000720801-mRNA-1};
GN ORFNames=TTAC_LOCUS7193 {ECO:0000313|EMBL:VDM31534.1};
OS Hydatigena taeniaeformis (Feline tapeworm) (Taenia taeniaeformis).
OC Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC Eucestoda; Cyclophyllidea; Taeniidae; Hydatigera.
OX NCBI_TaxID=6205 {ECO:0000313|Proteomes:UP000046396, ECO:0000313|WBParaSite:TTAC_0000720801-mRNA-1};
RN [1] {ECO:0000313|WBParaSite:TTAC_0000720801-mRNA-1}
RP IDENTIFICATION.
RG WormBaseParasite;
RL Submitted (FEB-2017) to UniProtKB.
RN [2] {ECO:0000313|EMBL:VDM31534.1, ECO:0000313|Proteomes:UP000274429}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Pathogen Informatics;
RL Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor Fz/Smo family.
CC {ECO:0000256|ARBA:ARBA00008077}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; UYWX01020352; VDM31534.1; -; Genomic_DNA.
DR STRING; 6205.A0A0R3X1U4; -.
DR WBParaSite; TTAC_0000720801-mRNA-1; TTAC_0000720801-mRNA-1; TTAC_0000720801.
DR Proteomes; UP000046396; Unplaced.
DR Proteomes; UP000274429; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR GO; GO:0007166; P:cell surface receptor signaling pathway; IEA:InterPro.
DR CDD; cd15909; 7tmF_FZD4_9_10-like; 1.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 1.20.1070.10; Rhodopsin 7-helix transmembrane proteins; 1.
DR InterPro; IPR015526; Frizzled/SFRP.
DR InterPro; IPR000539; Frizzled/Smoothened_7TM.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR017981; GPCR_2-like_7TM.
DR PANTHER; PTHR11309; FRIZZLED; 1.
DR PANTHER; PTHR11309:SF99; FRIZZLED-4; 1.
DR Pfam; PF01534; Frizzled; 1.
DR Pfam; PF01392; Fz; 1.
DR PRINTS; PR00489; FRIZZLED.
DR SMART; SM00063; FRI; 1.
DR SMART; SM01330; Frizzled; 1.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS50261; G_PROTEIN_RECEP_F2_4; 1.
PE 3: Inferred from homology;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00090};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000274429};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 23..756
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5040668603"
FT TRANSMEM 264..286
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 298..318
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 358..379
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 400..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 438..466
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 487..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 557..577
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 40..159
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT DOMAIN 259..583
FT /note="G-protein coupled receptors family 2 profile 2"
FT /evidence="ECO:0000259|PROSITE:PS50261"
FT REGION 596..636
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 730..756
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 607..623
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 45..106
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 53..99
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
FT DISULFID 122..146
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00090"
SQ SEQUENCE 756 AA; 83271 MW; 50149F66E082AE97 CRC64;
MTGKDITWLI PLLLLTATSI KGDSEPFHGL KKPPNYHDDD DQAQCTPIRE PVCQGLQYTD
TRMPNWVKMT SQEEAAKRMI DYKSLLNINC SHYLKLFLCT IYFPMCAPVL EKTPLKPCKS
LCVHVRGRCE PIMQQFQFSW PTELACDDLP EPPDLCIQPD GYALDAQKPV LPAASSNVAS
LQRMYPQLQD LFLKRGHGPP NIDTLIQAAA AAVADGSASA ASSGSSNVCS GAEFSAAHFS
NDTCFTYCGA DLFYRPGDKK FARAWLLGWS ILCVASSALT FFTFFIDGSR LQYPERPVLY
LAACYFVIGV GYILQYALGP ERVTCRSLQA GDSNGADIQK HLLMGGQEST WCTVGFLISY
YFGMASNFWW VMLSLAWYLS TSRKWGHEGV ESVSSVFHMF AWALPAIQAI LILILHKIDA
DELTGTCYTG FHSEASLMFG VLLPQAICLL LGLLLLSVGF AAVFRVRRKL KAPSERERES
RRRLEKSIAK LGVFVVLYTF PMACLLASNL YEYLGQPRWR AALRELNAAR PHCLSPRGVA
WGLPECHPND SPSSEAAMLR IFMSFVVGIT SGMWVWANKK TLVSWKRAIF RGCRSRAPPL
PHPQPPQQQQ SQQQRSKFER NNTYRTPGYG GPLSADATDV DRPAAVFATD ANTIFSASAV
GYTSSGACQS CHICPPPPAP APTDLTGGGY SSTSGQSGLE MYGECYMHQH LAAAALPHDQ
RFQRHQGFPF QSGDASAGNG GLASLMHRPP NTSECV
//
