ID   A0A0R3XC14_HYDTA        Unreviewed;       483 AA.
AC   A0A0R3XC14;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   27-MAR-2024, entry version 28.
DE   RecName: Full=2',3'-cyclic-nucleotide 3'-phosphodiesterase {ECO:0000256|ARBA:ARBA00014478};
DE            EC=3.1.4.37 {ECO:0000256|ARBA:ARBA00012317};
GN   ORFNames=TTAC_LOCUS11074 {ECO:0000313|EMBL:VDM36054.1};
OS   Hydatigena taeniaeformis (Feline tapeworm) (Taenia taeniaeformis).
OC   Eukaryota; Metazoa; Spiralia; Lophotrochozoa; Platyhelminthes; Cestoda;
OC   Eucestoda; Cyclophyllidea; Taeniidae; Hydatigera.
OX   NCBI_TaxID=6205 {ECO:0000313|Proteomes:UP000046396, ECO:0000313|WBParaSite:TTAC_0001109101-mRNA-1};
RN   [1] {ECO:0000313|WBParaSite:TTAC_0001109101-mRNA-1}
RP   IDENTIFICATION.
RG   WormBaseParasite;
RL   Submitted (FEB-2017) to UniProtKB.
RN   [2] {ECO:0000313|EMBL:VDM36054.1, ECO:0000313|Proteomes:UP000274429}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Pathogen Informatics;
RL   Submitted (NOV-2018) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=a nucleoside 2',3'-cyclic phosphate + H2O = a nucleoside 2'-
CC         phosphate + H(+); Xref=Rhea:RHEA:14489, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:66954, ChEBI:CHEBI:78552; EC=3.1.4.37;
CC         Evidence={ECO:0000256|ARBA:ARBA00000610};
CC   -!- SUBUNIT: Exists as monomers and homodimers.
CC       {ECO:0000256|ARBA:ARBA00011781}.
CC   -!- SUBCELLULAR LOCATION: Melanosome {ECO:0000256|ARBA:ARBA00004223}.
CC       Membrane {ECO:0000256|ARBA:ARBA00004635}; Lipid-anchor
CC       {ECO:0000256|ARBA:ARBA00004635}.
CC   -!- SIMILARITY: Belongs to the 2H phosphoesterase superfamily. CNPase
CC       family. {ECO:0000256|ARBA:ARBA00008662}.
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DR   EMBL; UYWX01022872; VDM36054.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0R3XC14; -.
DR   STRING; 6205.A0A0R3XC14; -.
DR   WBParaSite; TTAC_0001109101-mRNA-1; TTAC_0001109101-mRNA-1; TTAC_0001109101.
DR   Proteomes; UP000046396; Unplaced.
DR   Proteomes; UP000274429; Unassembled WGS sequence.
DR   GO; GO:0042470; C:melanosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0004113; F:2',3'-cyclic-nucleotide 3'-phosphodiesterase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009214; P:cyclic nucleotide catabolic process; IEA:InterPro.
DR   Gene3D; 3.90.1740.10; 2',3'-cyclic nucleotide 3'-phosphodiesterase superfamily; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR008431; CNPase.
DR   InterPro; IPR047325; CNPase_cat.
DR   InterPro; IPR009097; Cyclic_Pdiesterase.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR10156; 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE; 1.
DR   PANTHER; PTHR10156:SF0; 2',3'-CYCLIC-NUCLEOTIDE 3'-PHOSPHODIESTERASE; 1.
DR   Pfam; PF13671; AAA_33; 1.
DR   Pfam; PF05881; CNPase; 1.
DR   SUPFAM; SSF55144; LigT-like; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Lipoprotein {ECO:0000256|ARBA:ARBA00023288};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Methylation {ECO:0000256|ARBA:ARBA00022481};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Prenylation {ECO:0000256|ARBA:ARBA00023289};
KW   Reference proteome {ECO:0000313|Proteomes:UP000274429};
KW   RNA-binding {ECO:0000256|ARBA:ARBA00022884}.
FT   DOMAIN          314..429
FT                   /note="Cyclic nucleotide phosphodiesterase catalytic"
FT                   /evidence="ECO:0000259|Pfam:PF05881"
FT   REGION          28..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   483 AA;  54403 MW;  06993D431DDF0F63 CRC64;
     MGQTCVKLCS QSCVSRFLRG LGVRRPPPQR VENHLIEESS DDSNATGDNI KSPSKCKYVD
     YPFLVNREIG EWIVFTKFMI ILRGPPGSGK SRLAGYIKMR FPTAHICSSD NYHSSSIKYF
     EDYQFDSDRH ESALHDCEAE AKLYASRGIS PLVIDNANMR SYECRPYTEI ARAFDYNVIM
     VIPRTPWRFD VRSLAEYNAH NLSAEMISSM VSQFEPIVYP LYYGWAFAGS PSSNTHLSIP
     IEKGDKLLPN EVTEKMIKEF HDSFFSALDL PYVRKRLALI CGFNQDINRD QLATFWSSAV
     NPWFGDVSEP YRTDKPARPH CTAFFAQHGH APGASEYAQK TAVREALLGS IDELCVEGLF
     ITKRTVGLRI HLSDPDQLAL WGGLDNEPVD GHVTPQSRPQ GCRAHVTLAL ASGVPAVETG
     FDALRIMDAE LRQLPDVYTA DMPDGILREL PISSSADSES LDNIFYYQYS TAKTIRLMYT
     AFY
//