GenomeNet

Database: UniProt
Entry: A0A0R4IA72_DANRE
LinkDB: A0A0R4IA72_DANRE
Original site: A0A0R4IA72_DANRE 
ID   A0A0R4IA72_DANRE        Unreviewed;      4864 AA.
AC   A0A0R4IA72;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   22-NOV-2017, entry version 13.
DE   SubName: Full=Ryanodine receptor 3 {ECO:0000313|Ensembl:ENSDARP00000131111};
GN   Name=ryr3 {ECO:0000313|Ensembl:ENSDARP00000131111,
GN   ECO:0000313|ZFIN:ZDB-GENE-041001-165};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000131111, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000131111, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000131111,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000131111}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000131111};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000131111}.
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DR   EMBL; BX248136; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX682544; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR628343; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000172634; ENSDARP00000131111; ENSDARG00000071331.
DR   ZFIN; ZDB-GENE-041001-165; ryr3.
DR   GeneTree; ENSGT00760000119152; -.
DR   Reactome; R-DRE-2672351; Stimuli-sensing channels.
DR   Reactome; R-DRE-5578775; Ion homeostasis.
DR   Proteomes; UP000000437; Chromosome 20.
DR   ExpressionAtlas; A0A0R4IA72; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0R4IA72};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4405   4425       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4471   4492       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4616   4641       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4664   4686       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4745   4768       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       96    153       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      160    205       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      213    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    330       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    397       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      597    795       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1011   1206       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1252   1466       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3936   3962       EF-hand. {ECO:0000259|PROSITE:PS50222}.
FT   COILED     3595   3617       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4864 AA;  550490 MW;  07F5AAFF14553201 CRC64;
     IADRVSGQSV FAFLCKEDEV VLQCVAAIQK ENRKFCLSAE GLGNRLCYLE PTSEAKYVPP
     DLCICNFVLE QSLSVRALQE MLAGQSGEGA AQGGGHRTLL YGHAILLRHS FSGMYLTCLK
     TSRSLTDKLS FDVGLQEDST AKGEACWWTI HPASKQRSEG EKVRIGDDLI LVSVSSERYL
     HLSISNGSIQ VDASFMQTLW NVQPTCSRSS VAVGYLLGGQ VMRLFHGHDE SLTIPGYEQS
     QEQQRVVNYE AGKGGSKARS LWRLEPLRIS WSGSHMRWGQ PFRLRHLSTG HYLGQTEDQG
     LILLDREKSD TAATAFCFRP SKEKIESGPK RDIDGMGIAE IKYGDSVCFI MHVSTGLWLS
     YQAPDAKSSR LGPLKRRAFL SPEGHMDDGL ILQLCQHEES RAARIIRNTT HLFTQFIRGL
     DSLSGEKASE VTLPVSEVLE TLNDLIVYFQ QPDSELEHEE KQRQLRSLIK RQDLFKEEGM
     LTLLSHCIDR LNVYNSAAEF EELAGEEAGE AWKDILNLLY ELLAALIKGN RTNCTQFSRK
     LDWLVSKLER LESSSGILEV LHCILNESPE SLNIIQKAHI KSIISLLYKH GRNYKILDVL
     CSLCVCNGVA VRANQNFICD HLLPRRDLLL QTRLVNDVQS MRPNIFLGMS EGSAQYRKWY
     FELIIDQVDH FVTSEPTHLR VGWATTKGYA PYPGGGEGWG GNGVGDDLYS YGFDGLHLWA
     GRIPRAVASI NQHLLNSDDV VSCCLDLGAP SMSFRINGQP VQGMFEDFNV DGFFFPVVSF
     SAGVKVRFLL GGRHGDFKFL PPAGYAPCYE ALLPKEKMRV EPVKEYKRDL EGVRDLLGTT
     EFLSQASFIP VPVDTSQIVL PPHLENVRDK LAENIHELWG MNKIELGWMY GKVRDDNKRQ
     HPCLVDFSKL PETEKNYNLQ MSTETLKTLL ALGCHVAQVN INAEDDLKKM KLPKNYMMAN
     GYKPTPLDLS EIKLNPGQEV LVDKLAENAH NVWAKDRIKQ GWTYGIQQDL KNRRNPRLVP
     YALLDERTKK SNRDSLREAI RTLVGYGYFI DPPDQETAHQ VEKEGIESIR LFRVEKTYAV
     KTGKWYFEFE AITGGDMRVG WARPGCRPDI ELGMDDQSFV FDGHRGRRVH MGSHFFARSW
     NKGDVVGCLI NMEDKSMIFT LNGEILITNK GSELCFADFE TEDGFIPVCS LGLSQIGRMN
     LGKDASTFKY YTMCGLQEGF EPFAVNMNRE VTMWFSKRLP TFVNVPEDHP HIEVTRIDGT
     VDTPPCLKVT HKTFGTQTSN DDMICCRLSM PVEFHAGPRK ITDINEVIAE DQRAKKDDGG
     KVDYGSITKY FYSVKVFAGQ DPSSVWLGWV TPDYHYYSKH FSLDTVRTVT VTLGDERGRV
     HESVRRSNCY MVCAGDVASS STSRSNVDLE IGCSIDLASG LVSFTANGRE LPTAYQVEPN
     TKLFPAVFVQ PTSPNLFQIE FPKIPDAMPL SSAIFKSLLK NPEPQCPPRL DVQTIVSVLW
     SRMPNTFLTV ETARVSERHG WVVQCLEPLQ MMAVHIPEEN RCIDIMELSE NEDLRKFHYH
     TLKLFCSLCA LGNTRVAHSL CSHLGQSQFL YIIDNQYLTG QLREGFYNVL ISIHLETAKE
     ARLMMNNEFI IPVTDETRSI RLFPDDSKRH SLPGVGLSTS LTPRLNFTPP CFITTKRETP
     LYSPQIPLAI MKEKAISMLT EAVQGGGAHI RDPVGGSVEY QFVPILKLIG TLLIMGAMTS
     EEVKTILLLI EPIVFGDSKE EEEQTAVVEQ GAEKEEATSN EEKAVEAGEE EGKESKQPPK
     GLLETSLPES VKRQMCELLH YFCDCELKQR IEAIVAFSDD FVSKLQFNQK FRYNELMLAL
     NMSAAVTAKK TREFRSPPQE QINMLLNFSA GDDCTCPEEL QEELQTFHND LRLHCGIPME
     EEEEEQDTSL KGRLMAIIYK IKGRPQKTEE EPTKQEQATP TNLKELISQT MVSWAQEYKI
     QDPELVRSMF SLLRRQYDGI GELLRALRKS YTISDKSVGD AINLLASLGQ IRSLLSVRMG
     EEEGQLMIDG LGDIMNNKVF YQHPNLMRVL GMHETVMEVM VNVLGGDKNK EIAFPKVVAS
     CCRFLCYFCR ISRQNQKSMF DHLSYLLENS SVGLACPEMR GSTPLDVAAS SVMDNNSLAL
     ALEEPDLEKV VTYLAACGLQ NCPMLIARGY PDIGWNPIEG ERYLSFLRFA VFVNGESVEE
     NANVVVKLLI RRPECFGPAL RGEGGQGLLA AMKEAIKISE DPALDLPSLP EGVAPTFDRV
     VEDEEEVAHM GNSIMSFYSA LIDLLGRCAP EMHLINKGKG EALRIRAILR SLVPIKDLVG
     IISIPLKMPV VNKDGTVTEP DMNASFCPEH KAPMVLFLDR VYGVDDQSFL LHLLEVGFLP
     DLRASASLDS EVLRSTETAL AMNRYIGSAV LPLLTRCAHL FAHTEHYATL VDSTLHTIYR
     LSKGRSLTKA QRDAIDECLL AICMHLRPSM LQQLLRRLVF DVPQLTEYCK MPIKLLTNHY
     EQNWKYYCLP TGLGSYGMAS EEELHLTKKL FWGLFDALSQ KKYDSELFKM AMPCLSAIAG
     AIPPDYVDSS PGSALVKQAS VDAQGNFDPQ PINTANISLP EKLDYIASKF AEHSHEKWSS
     EKIALGWTVG DKVDDKAKTH PLLKPYKALS EKERETYRYP VKETLKSMLA MGWNIERTKE
     GEAMFQQRET EKQRKISEST QGDFIPAPQD LENVVLSREL QAMVETVAEN YHNIWAKKKK
     KELDSKEGGG SHPLLVPYDT LTAKEKYRDR DKAQELFKFL QVNGYAISRG LKDMEQDSSS
     MEKRFAYKFL KRLLSYVDSA QEFIAHLEAM ATSGKTDKSP HDQEIKFFAK ILLPLIDQYF
     KNHCLYFLSS PNINLSSSGY ASNKEKEMIT SLFCKLAALV RHRISLFGSD SATMVSCLHI
     LSRTLDFRTV MKSGSELVKA GVRTFFENAA EDLEKTLENL KLGKLGQSRT QMKGVTQIIS
     YTSVALLPML TVLFQHVTQH QFGAELLLDD IQLSCYRILT SLYSLGTGKN IYVEKQLPVL
     GECLSSLVGA MPVAFLEANL NMHNPQSVFN TKTPRERAIL SMPDTVDEMC PEMPHLDGLM
     KEIGDISESG ARYTEMPQII EVVLPMLCNY LSYWWAKGPE NSPDGANCCT SVTSEHLSLI
     LGNILKILNN NLGIENAPWM KRLAVYTQPI ISRASADLLR AHFLPTLEKL KKKTVKVVSE
     EEMLRAESRA DTQEAELQIL DEFAVLCRDL YAFYPMLIRY VDNNRSTWLK EPDSDSTELF
     KMVSEIFILW CKSHNFKREE QNFVVQNEIN NLAFLAGDSK SKMSKSGGQD QERRGKKRRG
     ELYSVQTSLI VAAHKKMLPI GLNMCTPGDQ ELISLAKIRY SLKDTDDEVK DYLRKNLHLQ
     EKSEDPAVQW QINLYKDIVL KSEGPPDPEQ NVERIQAISS AVYHLDQVEL PLRNKKILFQ
     KLLSKQRKRA VVACFRMAPL YNLPRHRSIN LFLSGYQRLW IETEEYSFEE KLVQDLAKTP
     MTVVEEEEEE EAEVQPDPLH QLILHFSHNA LTERSFLEED PLYIAYADMM AKSCAENEEE
     EEEEEGKEKT FEEKEMEKQK ILYQQARLHA RGAAEMVLQM ISASKGRLGP MVTGTLKLGI
     SVLNGGNVLV QQKMLDYLKE KRDAGFFKSL SALMMSCSIL DLNAFERQNK AESLGMVTEE
     GSISVKGRGS KVLQNDDFTK DLFRFLQLLC EGHNNADFQN FLRTQTGNTT TVNIIISTVD
     YLLRLQESIS DFYWYYSGKD VMDEAGQHNF SKALSVAKQI FNSLTEYIQG PCIGNQQSLA
     HSRLWDAVVG FLHVFANMQM KLSQDSSQIT LLKELMDLQK DMVVMMLSLL EGNVVNGTIG
     KQMVDTLVES SSNVEMILKF FDMFLKLKDL TSSDNFKEYD PDCKGMISKR DFQKSMESQK
     QYTQSEIEFL LSCVEADEND MFNYSDFVER FHEPAKDIGF NVAVLLTNLS EHMPHDSRLS
     TFLDLAESVL SYFEPYLGRI EIMGGAKRIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV
     VNEGGESEKM EMFVNFCEDT IFEMQLASQI SEPDPTERPE EEEEEELHSL LEGLSEEEDA
     SLESASAFTA ACASVKKSMS NFRQMLTFKS MKKQMKKFRK LTIREMITGF FSFFWMLFTG
     FFKGIFGIIF GFFHIIWSSM FGGGLVEGAK NMKVTDILGN MPDPTQFGIH GDVLEAEKAE
     ISEMVVSADM VQMTGAGGGE KLETDVIMDL LNPAVKKEGK HGAEPGLGDV CEILTETSAP
     VEKKKSQKVA AEKPESEPEK ADTENQEKED KTKEEAPEEP AAEKPAPKVK RGSSKDESPA
     FMASFFAGLE VYKTKMLNYL ARNFYNLRFL ALFVAFAINF ILLFYKVTGD FDDEEEEEGS
     WGGEEEEADE DEGGMEYFIL QESTGYMAPT LTFLAVLHTV ISLLCVFGYY CLKVPLVVFK
     REKEIARKLE FDGLYITEQP SDDDIKGQWD RLVIATPSFP NNYWDKFVKR KVINKYGDLY
     GAERIAELLG LDKSALDFDP TEEAVVKEAS LLSWLSSIDT KYHVWKMGVV MTDNSFLYLI
     WYTTMSILGH YNNFFFAAHL LDIAMGFKTL RTILSSVTHN GKQLVLTVGL LAVVVYLYTV
     VAFNFFRKFY NKSEDEDAPD MKCDDMMTCY LFHMYVGVRA GGGIGDEIED PAGDPYELYR
     ILFDITFFFF VIVILLAIIQ GLIIDAFGEL RDQQEQVKED METKCFICGI GNDYFDRTPH
     GFETHTLQEH NLANYLFFLM YLINKDETEH TGQESYVWKM YQERCWDFFP AGDCFRKQYE
     DQLG
//
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