ID A0A0R4ICQ1_DANRE Unreviewed; 352 AA.
AC A0A0R4ICQ1; A0A8M1NA46;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 41.
DE SubName: Full=NDRG family member 4 {ECO:0000313|Ensembl:ENSDARP00000130451};
DE SubName: Full=Protein NDRG4 {ECO:0000313|RefSeq:NP_001038638.1};
GN Name=ndrg4 {ECO:0000313|Ensembl:ENSDARP00000130451,
GN ECO:0000313|RefSeq:NP_001038638.1,
GN ECO:0000313|ZFIN:ZDB-GENE-060512-226};
GN Synonyms=si:ch211-194m7.2 {ECO:0000313|RefSeq:NP_001038638.1},
GN zgc:136766 {ECO:0000313|RefSeq:NP_001038638.1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000130451};
RN [1] {ECO:0000313|RefSeq:NP_001038638.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038638.1};
RX PubMed=18407257; DOI=10.1016/j.ydbio.2008.02.044;
RA Qu X., Jia H., Garrity D.M., Tompkins K., Batts L., Appel B., Zhong T.P.,
RA Baldwin H.S.;
RT "Ndrg4 is required for normal myocyte proliferation during early cardiac
RT development in zebrafish.";
RL Dev. Biol. 317:486-496(2008).
RN [2] {ECO:0000313|RefSeq:NP_001038638.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038638.1};
RX PubMed=18936300;
RA Lefebvre K.A., Tilton S.C., Bammler T.K., Beyer R.P., Srinouanprachan S.,
RA Stapleton P.L., Farin F.M., Gallagher E.P.;
RT "Gene expression profiles in zebrafish brain after acute exposure to domoic
RT acid at symptomatic and asymptomatic doses.";
RL Toxicol. Sci. 107:65-77(2009).
RN [3] {ECO:0000313|RefSeq:NP_001038638.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038638.1};
RX PubMed=21448936;
RA Sedletcaia A., Evans T.;
RT "Heart chamber size in zebrafish is regulated redundantly by duplicated
RT tbx2 genes.";
RL Dev. Dyn. 240:1548-1557(2011).
RN [4] {ECO:0000313|Ensembl:ENSDARP00000130451, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000130451};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [5] {ECO:0000313|RefSeq:NP_001038638.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038638.1};
RX PubMed=25189322;
RA Song B., Zhang Q., Zhang Z., Wan Y., Jia Q., Wang X., Zhu X., Leung A.Y.,
RA Cheng T., Fang X., Yuan W., Jia H.;
RT "Systematic transcriptome analysis of the zebrafish model of diamond-
RT blackfan anemia induced by RPS24 deficiency.";
RL BMC Genomics 15:759-759(2014).
RN [6] {ECO:0000313|RefSeq:NP_001038638.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038638.1};
RX PubMed=24989799;
RA Balci T.B., Prykhozhij S.V., Teh E.M., Da'as S.I., McBride E., Liwski R.,
RA Chute I.C., Leger D., Lewis S.M., Berman J.N.;
RT "A transgenic zebrafish model expressing KIT-D816V recapitulates features
RT of aggressive systemic mastocytosis.";
RL Br. J. Haematol. 167:48-61(2014).
RN [7] {ECO:0000313|Ensembl:ENSDARP00000130451}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000130451};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [8] {ECO:0000313|RefSeq:NP_001038638.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038638.1};
RX PubMed=27827822;
RA Li R.A., Traver D., Matthes T., Bertrand J.Y.;
RT "Ndrg1b and fam49ab modulate the PTEN pathway to control T-cell
RT lymphopoiesis in the zebrafish.";
RL Blood 128:3052-3060(2016).
RN [9] {ECO:0000313|RefSeq:NP_001038638.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038638.1};
RX PubMed=27471727;
RA D'Aurizio R., Russo F., Chiavacci E., Baumgart M., Groth M., D'Onofrio M.,
RA Arisi I., Rainaldi G., Pitto L., Pellegrini M.;
RT "Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a
RT Zebrafish Model.";
RL Front. Bioeng. Biotechnol. 4:60-60(2016).
RN [10] {ECO:0000313|RefSeq:NP_001038638.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038638.1};
RX PubMed=27902705;
RA Fontenas L., De Santis F., Di Donato V., Degerny C., Chambraud B.,
RA Del Bene F., Tawk M.;
RT "Neuronal Ndrg4 Is Essential for Nodes of Ranvier Organization in
RT Zebrafish.";
RL PLoS Genet. 12:e1006459-e1006459(2016).
RN [11] {ECO:0000313|RefSeq:NP_001038638.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038638.1};
RX PubMed=27046191;
RA Li F., Wang H., Liu J., Lin J., Zeng A., Ai W., Wang X., Dahlgren R.A.,
RA Wang H.;
RT "Immunotoxicity of beta-Diketone Antibiotic Mixtures to Zebrafish (Danio
RT rerio) by Transcriptome Analysis.";
RL PLoS ONE 11:e0152530-e0152530(2016).
RN [12] {ECO:0000313|RefSeq:NP_001038638.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038638.1};
RX PubMed=28252024;
RA Bayes A., Collins M.O., Reig-Viader R., Gou G., Goulding D., Izquierdo A.,
RA Choudhary J.S., Emes R.D., Grant S.G.;
RT "Evolution of complexity in the zebrafish synapse proteome.";
RL Nat. Commun. 8:14613-14613(2017).
RN [13] {ECO:0000313|RefSeq:NP_001038638.1}
RP IDENTIFICATION.
RC STRAIN=AB {ECO:0000313|RefSeq:NP_001038638.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytosol
CC {ECO:0000256|ARBA:ARBA00004514}.
CC -!- SIMILARITY: Belongs to the NDRG family.
CC {ECO:0000256|ARBA:ARBA00005598}.
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DR EMBL; AL772241; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; NP_001038638.1; NM_001045173.2.
DR STRING; 7955.ENSDARP00000130451; -.
DR ESTHER; danre-q1mti5; Ndr_family.
DR Ensembl; ENSDART00000163735; ENSDARP00000130451; ENSDARG00000103937.
DR Ensembl; ENSDART00000163735.2; ENSDARP00000130451.1; ENSDARG00000103937.2.
DR GeneID; 692305; -.
DR KEGG; dre:692305; -.
DR AGR; ZFIN:ZDB-GENE-060512-226; -.
DR CTD; 65009; -.
DR ZFIN; ZDB-GENE-060512-226; ndrg4.
DR OMA; CMADSGG; -.
DR OrthoDB; 5352016at2759; -.
DR Proteomes; UP000000437; Chromosome 25.
DR Bgee; ENSDARG00000103937; Expressed in cardiac ventricle and 41 other cell types or tissues.
DR GO; GO:0005737; C:cytoplasm; IBA:GO_Central.
DR GO; GO:0005829; C:cytosol; IEA:UniProtKB-SubCell.
DR GO; GO:0060038; P:cardiac muscle cell proliferation; IMP:ZFIN.
DR GO; GO:0045162; P:clustering of voltage-gated sodium channels; IMP:ZFIN.
DR GO; GO:0035050; P:embryonic heart tube development; IMP:ZFIN.
DR GO; GO:0001947; P:heart looping; IMP:ZFIN.
DR GO; GO:0070374; P:positive regulation of ERK1 and ERK2 cascade; IBA:GO_Central.
DR GO; GO:0007165; P:signal transduction; IBA:GO_Central.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR004142; NDRG.
DR PANTHER; PTHR11034; N-MYC DOWNSTREAM REGULATED; 1.
DR PANTHER; PTHR11034:SF21; PROTEIN NDRG4; 1.
DR Pfam; PF03096; Ndr; 1.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|PeptideAtlas:A0A0R4ICQ1};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437}.
FT REGION 300..352
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 308..352
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 352 AA; 38642 MW; 4843D1B2EC3D8436 CRC64;
MPECWDGEHD IETPYGMLHV VIRGAPKGNK PAILTYHDVG LNHKLCFNSF FQNEDMLEIT
KHFVVCHVDA PGQHIGAPQM PQGYQYPTMD QLAGMLPSVV QHFGFKSIVG IGVGAGAYIL
AKFALIFPDL VEGLVLLNID PNGKGWIDWA ATKLSGLTST LPDTVLTHLF SQEELMSNTE
VVQNYRQQIN NTINQFNLQL FWNMYNSRRD LEMNRSGSVI NAKTLRCPVM LVVGDNAPAE
EGVVECNSKL DPTNTTFLKM ADSGGMPQIT QPGKLTEAFK YFLQGMGYIA YMKDRRMSGG
PVPSASMTRL ARSRTASLTS AGSVDGSRNR ACTHSDSSEG VGQVSHTMEV SC
//
