GenomeNet

Database: UniProt
Entry: A0A0R4IF27_DANRE
LinkDB: A0A0R4IF27_DANRE
Original site: A0A0R4IF27_DANRE 
ID   A0A0R4IF27_DANRE        Unreviewed;      5061 AA.
AC   A0A0R4IF27;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   22-NOV-2017, entry version 12.
DE   SubName: Full=Ryanodine receptor 1a (skeletal) {ECO:0000313|Ensembl:ENSDARP00000134160};
GN   Name=ryr1a {ECO:0000313|Ensembl:ENSDARP00000134160,
GN   ECO:0000313|ZFIN:ZDB-GENE-020108-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000134160, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000134160, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000134160,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000134160}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000134160};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000134160}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BX088525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR759796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000170465; ENSDARP00000134160; ENSDARG00000011422.
DR   ZFIN; ZDB-GENE-020108-2; ryr1a.
DR   GeneTree; ENSGT00760000119152; -.
DR   Reactome; R-DRE-2672351; Stimuli-sensing channels.
DR   Reactome; R-DRE-5578775; Ion homeostasis.
DR   Proteomes; UP000000437; Chromosome 10.
DR   ExpressionAtlas; A0A0R4IF27; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0R4IF27};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4351   4374       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4581   4601       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4665   4686       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4801   4819       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4863   4883       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4942   4965       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       97    152       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      159    204       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      212    267       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      273    336       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      338    395       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      599    798       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1014   1210       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1344   1558       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1890   1928       {ECO:0000256|SAM:Coils}.
FT   COILED     3695   3722       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   5061 AA;  573395 MW;  0F1C03C0E750D956 CRC64;
     MAEGAEGEEE IQFLRTDDQV VLQCTATILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLANTTELNE SSQGGGHRTL LYGHAILLRH THSGMYLSCL
     TTSRSLTDKL AFDVGLQEDS TGEACWWTIH PASKQRSEGE KVRVGDDIIL VSVSSERYLH
     LSYASGDLMV DASFMQTLWN MNPVCSGCEL AEGFLTGGHV LRLFHGHMDE CLTIPGAEQG
     DDQRRNAHYE GGAVCSHARS LWRLEPLRIG WSGSHMKWGQ SFRVRHITTG RYLCLDEEKG
     LLIVDPEKAN TKQSAFCFRA SKEKTEVAQK RDVEGMGIPE IKYGESMCFV QHVATSLWLT
     YASVDAKSAR LGPLKRKAIL HQEGHMDDAL TVARSQTAES QAARMIYNTA GLFTQFIKGL
     DSLSGKSKSP GPSPSLPLDA IVLSLQDLIF YFRPPEEELE HEEKQTKLRS LRNRQNLFQE
     EGMITLVLDC VDRLNVYNTS AHFSEFAGED AAESWKEIVN LFYELLASLI RGNRANCALF
     CDNLDWLVSK LDRLEASSGI LEVLYCILIE SPEVLNIIQE NHIKSIIALL DKHGRNHKVL
     DVLCSLCVCN GVAVRSNQNL ITENLLPGRD LLLQTNIINY VTSMRPNIFL GTCEGSTQYK
     KWYYELIVDH VESFLTAHPF HLRVGWALTE GYSPYPGGGE GWGGNGVGDD LHSYGFDGLN
     LWTGRVPRQV TSPSQHILSA EDVVSCCLDL SVPSISFRIN GHPVQGMFEN FNLDGLFFPV
     VSFSAGIKVR FLLGGRQGDF KFLPPPGYAP CYEAVLPKDR LRIEPIKEYK HDNDGVRNLL
     GPTQSLSHTA FTPCPVDTVQ IVLPPHLERI REKLAENSHE LWAVTRIEQG WTYGLFRDDN
     KKLHPCLVDF QSLPDPEKSY NLAMSGETLK TLLALGCHVG MGDEKAEENL KKIKLPKTYM
     QCNGYKPAPL DLNHVKLTPN QNTLVERLAE NGHNVWARDR VRQGWTYSII QDIVNKRNPR
     LVPYILLDEK TKKTNRDTVC AAVRTLIGYG YNIEPPDQES SGHGGGNGRS DKIRVFRAEK
     SYAVTQGKWY FEFEAVTVGE MRVGWARPSV HADRELGSDD LAYVFNGFKS QRWHIGNEPF
     GRQWQSGDVV GCMIDLTEQN IMFTLNGEML ISDSGSEMAF KDIEIGEGFI PVCSLGMSQV
     GRINLGQNVS SLRYFTICGL QEGFEPFAIN MKRDITMWFS KSLPQFVPVP TDHPHIEVSR
     VDGTVESAPC LKLTHRTFGS QNANTDLLFF RLSMPIEFHE TFKVPVGASP LTRTLTIPED
     ETLEVDPESE FELLKKSATR KEQDEKEKEP SVPKELPGSK ESENEKDTTT EKSKKRGFFS
     KAKKAAFIAP PPVVPTMPRL MEDVVPDDRD DVEIISNTTT YYYSVRVFAG QEPSGVWVGW
     VTPDYHLYDL HFDLCKVRNV TVTVGDDKGN IHDSVKRSNC YMVWGGEFSS SQQTRISQED
     FVIGCLVDLD TGLMTFTANG KEINTFYQVE PNTKLFPAVF CLPSSQNMLQ VELGKLKNIM
     PISAAMFRSD CKNPVPQCPP RLDLQMLTPV IWSRMPNHFL SPETGRVSER QGWKVQCMEP
     LVMMALHIPE ENRCIDILEL SERTDLMKFH YHTLKLYGSV CALGNNRVAH ALCSHVDESQ
     LFYAIENTYL PGPIRSGYYD LLISMHLESA KRNRLMTNKE FIVPMTDETR SITLYSDAEK
     AHALPGVGLT TCLRPKLHFA PTGFVGTNAD LYTLSPMLPL QMLKDHALSM LTEAVQDGGQ
     AIRDPVGGSV EYHFVPILKL ISTLLIMGVF DDDDVKHILK LIEPSVFSSN SETPAEETGD
     PEQQLVCKEE GAEVKEQEEP ADGGNDGELL DEGMGEEEEL EEEEEEEDEE YEEEVKKEED
     EHAAEKTDRE KTTDGETEKE TGAAEAEVRE EEDVGEGLLH MKLPESVKLQ MCTLLQYFCD
     CELRHRVEAI IAFSDKFVNQ VQTNQRQRYN ELMQAFTMSA AETARKTREF RSPPQEQVNM
     LMNFKNCPEE EDCPVPEDVR NGLLTFHHDL LAHCVGVHIE EEEQEEEVDT SLSGRLRRLV
     EKVKSLRKKP EAEPEPEEDK KPSTLQELIS HTMIYWAQES FIQNPELVRL MFSLLHRQYD
     ALGELIRALP KAYIINAVSI QDTMELLECL GQIRSLLIVQ MGPEEERLMI QSIGNIMSNR
     VFYQHPNLMR ALGMHETVME VMVNVLGGGD SKEIRFPRMV TNCCRFLCYF CRISRQNQRS
     MFDHLGYLLQ NSGIGLGMRG STPLDVAAAS CIDNNELALA LQEQDLEMVV KYLAGCGLQS
     CPMLLSKGYP DIGWNPVGGE KYLDFLRFAV FVNGESVEEN ANVVVRLLIR RPECFGPALR
     GEGGNGLLAA IEEAIKISED PARDGPTVKK DRRFPMFGGE EQHEENRVHL GNAIMSFYSA
     LIDLLGRCAP EMHLIQAGKG EALRIRAILR SLVPIEDLVG VISLSVQIPA FGKDNSIIEP
     KMSASFVPDH KAPMVLFLDR VYGIDNQDFL LHVLEVGFLP DMRAAASLDT AAFSTTEMAL
     ALNRYLCSAV LPLITKCAPL FAGTDHRAIM IDSMLHTIYR LSRGRSLTKA QRDVIEECLM
     SLCRYLRPSM LQHLLRRLVF DVPILNEYAK MPLKLLTNHY ERCWKYYCLP NGWANFGVSS
     EEELHLTRKL FWGIFESLAH KKFDAELFKI AMPCICAIAG AIPPDYVDAS YSSKTEKKAS
     VDAEGNFDPK PVDTTNTIIP EKLDGFINRY AEYTHDRWAF EKIQNNWTFG EVMDENAKTH
     PMLRPYKTFS EKDKEIYRWP IKESIKAMIA WEWTLDKARD GEDEKVEKKT ARKISQTAQA
     TYDPSHGYSP QPIDISGMTL SRELQSMAEQ LAENYHNTWG RKKKMELQAK GGGTHPLLVP
     YDTLTAKEKA RDREKAYELL KFLQLNGYAV TRGLKDMESD ISSIEKRFAY GFLQKLLKWM
     DIAQEFIAHL EAVVSSGRVE KSPHEQEIKF FAKILLPLIN QYFKNHCLYF LSTPAKILGS
     GGHASNKEKE MIASIFCKMS ALVRHRVFLF GTDAPAIVNC LHILARSLDA RTVMKSGPEI
     VKAGLRLFFE SAADDIEKMV ENLKLGKVSK GNQPVKGVSQ NINYTTTALL PVLTSLFDHI
     AQHQFGDDVI LDDLQMSCYR IMCSIYSLGT VKTPHAERHR PALGECLAHL AAAMPVAYLE
     PHLNEYNAFS VYTTKTPRER AILGLPNQVQ ELCLDIPELD VLLKEIGDLA ESGARYTEMP
     HVIEVTLPML CNYLPRWWER GLENFPDLEG KLCTDVTSES LNQLLGSIMK IVVNNLGIDE
     ASWMKRLAVF SQPIVSRAKP EMLKSHFIPT MEKLKKRTSK VVAEEEHLRL EGKSEGDEEE
     GTIRDEFAVL CRDLYALYPL LIRYVDNNRA RWLTFRDPDA EELFRMVGEV FIFWSKSHNF
     KREEQNFVVM NEINNMSFLT ADSKSKMSKA GDSEAGGSDV ERTKKKRRGD RYSVQTSLIV
     AALKKMLPIG LNMCSPADQE LINLAKTRYS LKDTDEEVRE FLQNNLHLQG KVDNPSMRWQ
     MALYKEMAGK AEDADAPENV VKRVQEVSAV LYHIEVTEHP FKSKKMVWHK LLSKQRRRAV
     VACFRMTPLY NLPRHRASNM FLDGYKRNWI RNEGYSFEDR MIDDLSKALE EEEEEEEEKE
     TKPDPLHQLI LHFSRTALTE KSKLDIDHLY MAYADIMAKS CHMDEEDEGG EEENEGGEEE
     MSFEVRQTEM EKEMEKQRLL YQQSRLHNRG AAEMVLQMIS ACKGETGCMV SSTLKLGISI
     LNGGNCEVQQ KMLDYLKDKK DVGFFLSVQA LMQTCSVLDL NAFERQNKAE GLGMVSEEGT
     SEKVMADDEF TCDLFRFLQL LCEGHNNDFQ NYLRTQTGST TTINVIICTV DYLLRLQESI
     SDFYWYYSGK DIIDEPGKRN FSKAMTVAKQ VFNSLTEYIQ GPCTGNQQSL AHSRLWDAVV
     GFLHVFAHMM MKLAQDSSQI GLLKELLDLQ KDMVVMLLSL LEGNVVNGTI ARQMVDMLVE
     SSSNVEMILK FFDMFLKLKD IVASDAFRDY VTDPRGLISK KDFQKSMDSQ KQYTPSEIQF
     LLSCSEADEN EMINYEEFAS RFQEPAKDIG FNIAVLLTNL SEHVPHDTRL QNFLEQAESV
     LNYFRPFLGR IEIMGASRKI ERIYFEISEV NRKQWEMPQV KESKRQFIFD VVNEGGESEK
     MELFVNFCED TIFEMNIASQ ISEQDEEEKE EDDIEEAEGG DAGDEEGGGE EGQPESSSAF
     ADFIQSIMNF LGMFTFRNIR RKYRRLRKMT IKEIVVGLAT FMWTILLGIL HFIYSVCKGF
     FLLIWHTLFG GGLVEGAKNI TVTELLASMP DPTQDEVHGD LPGEPRGGEE QETGGIMDSM
     DAGGGEEEDE DIQEKDGGKI PGIDTPGGLG DMGDTTPVEP PTPEGTPLLK RKAQPDEAGA
     EQPPAIEEPP PEPEKADIEN GEKAEKEVEV KPEPIPEEPK PQRATKAKKE KKSVKGAGFE
     LWNELDVQRN KFMNCLSRNF YNIRFLALFL AFALNFILLF YKVSDTPPSS DEFEGSGIFE
     GSGLFEGSAE DFEGSGGEDG GDDEDEEGPV YYFLEESTGY MQPTLSFLAI LHTVIAFISI
     IGYNCLKIPL VIFKREKELA RKLEFDGLYI TEQPADDDIK GQWDRLVLNT PSFPTNYWDK
     FVKRKVLDKY GDIYGRERIA ELLGMDLASL DVSKQQTDKK PEEPDNSMLA WFTSIDIKYQ
     IWKFGVVFTD NTFLYLVWYT VMSLLGHYNN FFFACHLLDI AMGVKTLRTI LSSVTHNGKQ
     LMMTVGLLAV VVYLYTVVAF NFFRKFYNKS EDEDEPDMKC DDMMTCYLFH MYVGVRAGGG
     IGDEIEDPAG DEYELYRVVF DITFFFFVIV ILLAIIQGLI IDAFGELRDQ QEQVKEDMET
     KCFICGIGSD YFDTTPHGFE THTLEEHNLA NYMFFLMYLI NKDETEHTGQ ESYVWKMYQE
     RCWDFFPAGD CFRKQYEDQL G
//
DBGET integrated database retrieval system