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Database: UniProt
Entry: A0A0R4IFT1_DANRE
LinkDB: A0A0R4IFT1_DANRE
Original site: A0A0R4IFT1_DANRE 
ID   A0A0R4IFT1_DANRE        Unreviewed;      2313 AA.
AC   A0A0R4IFT1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 14.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=cacna1ba {ECO:0000313|Ensembl:ENSDARP00000134082,
GN   ECO:0000313|ZFIN:ZDB-GENE-060531-44};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000134082, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000134082, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000134082,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000134082}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000134082};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000134082}.
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DR   EMBL; AL929342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX571772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000166486; ENSDARP00000134082; ENSDARG00000021735.
DR   ZFIN; ZDB-GENE-060531-44; cacna1ba.
DR   GeneTree; ENSGT00830000128247; -.
DR   OMA; DSPRNNA; -.
DR   Reactome; R-DRE-112308; Presynaptic depolarization and calcium channel opening.
DR   Proteomes; UP000000437; Chromosome 5.
DR   ExpressionAtlas; A0A0R4IFT1; baseline.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 3.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     90    111       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    131    151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    163    181       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    218    240       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    294    315       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    327    349       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    488    507       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    513    531       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    552    570       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    613    635       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    689    713       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1155   1174       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1194   1215       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1227   1245       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1367   1392       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1448   1466       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1478   1501       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1569   1587       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1658   1681       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1818   1852       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      709    736       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2313 AA;  261325 MW;  1AAB010DCF2D9DD8 CRC64;
     MARFEDDLPT RYGGGGGGSP AGPGRGATRQ PGPPGGPRVY KQTMAQRART MAIYNPIPVK
     QNCLTVNRSL FIFSEDNIIR KYAKKITDKC LFLYMILATI IANCIVLGLE QHLPALDKTP
     MSKRLDDTEP YFIGIFCFEA GIKIIALGFA FHKGSYLRNG WNVMDFVVVL TGILTIVGPD
     FDLRTLRAVR VLRPLKLVSG IPSLQVVLKS IMKAMVPLLQ IGLLLFFAIL MFAIIGLDFY
     MGKFHRTCFR TDTGEQVDEF PCGLESPAWT CENGTECREY WIGPNFGITN FDNILFAVLT
     VFQCITMEGW VDILYNANDA SGNTWNWLYF IPLIIIGSFF MLNLVLGVLS GEFAKERERV
     EKRQEFLKLR RQQQIERELT GYLEWICKAE EVMLAEEDKN AEDKDDVAWY KRKCNNPVLK
     RAKKSKNDLI NAEEGEDHFT DISSVAPQGS PFTRTSVKSS KIESLSYFRR KEKRFRFFIR
     RMVKAQSFYW TVLCIVGLNT LCVAIVHYDQ PEWLTYALYL AEFVFLGLFL IEMSLKMYGL
     GPRTYFHSSF NCFDFGVIVG SIFEVIWAAV KPGASFGISV LRALRLLRIF KVTKYWNSLR
     NLVVSLLNSM KSIISLLFLL FLFIVVFALL GMQLFGGQFN FEDETPTTNF DTFPAAILTV
     FQILTGEDWN AVMYHGIESQ GGVHRGMFCS VYFIVLTLFG NYTLLNVFLA IAVDNLANAQ
     ELTKDEEEQE EAISKKLALQ KAKEVKEVSP MSAANISITA FIRPNPGALS CSSSNSSSHS
     PKEQQRSLKM MSVWEQRTTQ IRKHMLASSE ALYQEELNPR LMSNLPLRTD IKTHLDRPLV
     VEPRCDGPIS PHSGWDKPQD LQGEGSTPEE RVPPVFEPPQ SHPPRKHHRH RERLSNETNE
     NGDTGHAKEG RHHVHHSRSK EHDGTRCKEG KGDRSRSREG GRRHHHQSSV DEGVGGGERE
     HRHHHSHRHN REGNGVVSAG GKSERRSRQK EGSRSGTREG ERCSRGENGG NGGRRRHRPR
     TSKAQSTLEG EEQHVNGEEE GKHMDMGGDS MAVNPHQPSV GSRWCLEKPE DSDNKRNIGQ
     TGGMSTHIPV TVTSPPGETT LIPMNSIDSE TVPMTEKNLE DLNQSSIRPI LPFSSMFIFN
     PTNPVRRLCH YIVSLRYFEM CILVVIAMSS IALAAEDPVQ ANAPRNNVLK YLDYVFTGVF
     TFEMVIKMVD LGLILHPGSY FRDLWNILDF IVVSGALVAF AFSGTKGKDI STIKSLRVLR
     VLRPLKTIKR LPKLKLFKGK FFYCTDESKG LEKDCRGLFL DYDKDDVTAQ PREWKKYEFH
     YDNVLWAFLT LFTVSTGEGW PTVLKHSVDA TFEDQGPSPG YRIEMSIFYV VYFVVFPFFF
     VNIFVALIII TFQEQGDKVL SECSLEKNER ACIDFAINAK PLTRYMPQNQ QSFQYRLWKF
     VVSPPFEYSI MIMIALNTVV LMMKFHGAPD FYEAMLKYLN IVFTVLFSLE CILKIIAFGP
     LNYLKDAWNV FDFVTVLGSI TDILVTEINE RQLNFSFLRL FRAARLIKLL RQGYTIRILL
     WTFVQSFKAL PYVCLLIAML FFIYAIIGMQ VFGNIDLNDD TAINRHNNFR TFLQALMLLF
     RSATGEAWHD IMLSCLSERT CDPSSGTLGK ECGSDFAYFY FVSFIFLCSF LMLNLFVAVI
     MDNFEYLTRD SSILGPHHLD EFIRVWAEYD PAACGRIKYL DMYEMLLHMS PPLGLGKKCP
     PRIAYKRLVK MNMPIADDNS VHFTSTLMAL IRTALEIKLA SGMVAQRLSD AELKKELSTV
     WPNLSQKTMD LLVTPHKPNE LTVGKVYAAL MIFDYYKQNR AKRLQMQQQQ LKEQAGPGSQ
     NKVSALLEPI LPLTHMQDQP VNGVDSASEC QAQTRPSSTT LNNGRTTLDN TIKGSSSWAS
     EKSKEVQKSK RRPMSRGQSE DASNANTAQE SVEMRKMENS ANTVTSGGLE GQGRAASMPK
     LNAEMQRSHS RQSPGTLLEP IPDSPMRRSA STFAPQRPHE VNLNDYILEK PVQERHHHHH
     HHHRCHHRRD RDKKQRSLDR SPTGHHKTTG TATDSVEERA HDRGRSHERK HHSSSGEKQR
     YYSCDRYASR EHCSSKSAVA SCATSPSETQ EANLNKQGSG WAKGSPVLLT SGASTPSRGR
     RQLPQTPLTP RPSVAYRTAN SSPVQLLATT TSLLPPSPGR LSRGLSEHNA LLLSGSISSS
     PAPVSRINSE PFLGPPDHPA GLQPEAFAVF QENPSPQMGR SPQTVGMPFV AIPPPPPQQF
     RRVPNGYHFS TGPSASRGRA QQYYPEAEVE DWC
//
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