GenomeNet

Database: UniProt
Entry: A0A0R4IHZ1_DANRE
LinkDB: A0A0R4IHZ1_DANRE
Original site: A0A0R4IHZ1_DANRE 
ID   A0A0R4IHZ1_DANRE        Unreviewed;       407 AA.
AC   A0A0R4IHZ1;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   30-AUG-2017, entry version 13.
DE   SubName: Full=Sodium channel, voltage-gated, type I, alpha {ECO:0000313|Ensembl:ENSDARP00000133081};
DE   Flags: Fragment;
GN   Name=scn1a {ECO:0000313|Ensembl:ENSDARP00000133081,
GN   ECO:0000313|ZFIN:ZDB-GENE-040426-751};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000133081, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000133081, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133081,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000133081}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133081};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000133081}.
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DR   EMBL; AL929294; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU062479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000167098; ENSDARP00000133081; ENSDARG00000086819.
DR   ZFIN; ZDB-GENE-040426-751; scn1a.
DR   GeneTree; ENSGT00830000128242; -.
DR   Proteomes; UP000000437; Chromosome 9.
DR   ExpressionAtlas; A0A0R4IHZ1; baseline.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IC:ZFIN.
DR   GO; GO:0005216; F:ion channel activity; IEA:InterPro.
DR   GO; GO:0060078; P:regulation of postsynaptic membrane potential; IEA:GOC.
DR   GO; GO:0035725; P:sodium ion transmembrane transport; IEA:GOC.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR024583; Na_trans_cytopl.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF11933; Na_trans_cytopl; 1.
PE   4: Predicted;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     78    105       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       26    111       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      173    339       Na_trans_cytopl. {ECO:0000259|Pfam:
FT                                PF11933}.
FT   COILED      113    152       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSDARP00000133081}.
SQ   SEQUENCE   407 AA;  45957 MW;  3F859218EFF69416 CRC64;
     XNQYFLPGKK DALICGNSSD AGQCPEGYTC LKAGNNPDYG YTSFDSFGWA FLSLFRLMTQ
     DFWENLYQQT LRAAGKTYMI FFVLVIFLGS FYLVNLILAV VAMAYDEQNQ ATIDEALKKE
     EEFNAMLEQI TRQEQEAEAA AEQSKCEGLS GEKTDSSSDA SKLSSKSAKE RRNRKKKRQH
     QGESEKEEDS IKEGNDRKPN FTFAVDGKIR RSRDRSYTSP RQSPLSFQGS LLTPRRDSKA
     SVFSFRGRIH SDNNYADDEQ SMFEETGSRR DSLFLPTRPE RLFSNVSKSS LTPHLLLPSN
     GKARYVDDSN GMVMVTSGAS APNSPVIALN TPEVSRKRAM FDDTCVRTRL ISHGMRHCAC
     SLLMFMIRYV YVYSELSSLN MSLFCFSPFF AGFECKYANS GMHFVAN
//
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