GenomeNet

Database: UniProt
Entry: A0A0R4IIY9_DANRE
LinkDB: A0A0R4IIY9_DANRE
Original site: A0A0R4IIY9_DANRE 
ID   A0A0R4IIY9_DANRE        Unreviewed;      4890 AA.
AC   A0A0R4IIY9;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   20-DEC-2017, entry version 13.
DE   SubName: Full=Ryanodine receptor 1a (skeletal) {ECO:0000313|Ensembl:ENSDARP00000133524};
GN   Name=ryr1a {ECO:0000313|Ensembl:ENSDARP00000133524,
GN   ECO:0000313|ZFIN:ZDB-GENE-020108-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000133524, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000133524, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133524,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000133524}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000133524};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000133524}.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; BX088525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR759796; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000160113; ENSDARP00000133524; ENSDARG00000011422.
DR   ZFIN; ZDB-GENE-020108-2; ryr1a.
DR   GeneTree; ENSGT00760000119152; -.
DR   Reactome; R-DRE-2672351; Stimuli-sensing channels.
DR   Reactome; R-DRE-5578775; Ion homeostasis.
DR   Proteomes; UP000000437; Chromosome 10.
DR   ExpressionAtlas; A0A0R4IIY9; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 3.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 2.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50919; MIR; 5.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0R4IIY9};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4197   4220       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4424   4444       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4494   4515       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4630   4648       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4692   4712       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4771   4794       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      100    155       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      162    207       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      215    270       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      276    339       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      341    398       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      602    801       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1017   1213       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1259   1465       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED      464    484       {ECO:0000256|SAM:Coils}.
FT   COILED     3540   3567       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   4890 AA;  555220 MW;  69B162B76FFD12D9 CRC64;
     MAEGAEGEEE IQFLRTDDQV VLQCTATILK EQIKLCLSCE GFGNRLCFLE TTSNAQNVPP
     DLAICCFILE QSLSVRALQE MLANTTELNE EWASSQGGGH RTLLYGHAIL LRHTHSGMYL
     SCLTTSRSLT DKLAFDVGLQ EDSTGEACWW TIHPASKQRS EGEKVRVGDD IILVSVSSER
     YLHLSYASGD LMVDASFMQT LWNMNPVCSG CELAEGFLTG GHVLRLFHGH MDECLTIPGA
     EQGDDQRRNA HYEGGAVCSH ARSLWRLEPL RIGWSGSHMK WGQSFRVRHI TTGRYLCLDE
     EKGLLIVDPE KANTKQSAFC FRASKEKTEV AQKRDVEGMG IPEIKYGESM CFVQHVATSL
     WLTYASVDAK SARLGPLKRK AILHQEGHMD DALTVARSQT AESQAARMIY NTAGLFTQFI
     KGLDSLSGKS KSPGPSPSLP LDAIVLSLQD LIFYFRPPEE ELEHEEKQTK LRSLRNRQNL
     FQEEGMITLV LDCVDRLNVY NTSAHFSEFA GEDAAESWKE IVNLFYELLA SLIRGNRANC
     ALFCDNLDWL VSKLDRLEAS SGILEVLYCI LIESPEVLNI IQENHIKSII ALLDKHGRNH
     KVLDVLCSLC VCNGVAVRSN QNLITENLLP GRDLLLQTNI INYVTSMRPN IFLGTCEGST
     QYKKWYYELI VDHVESFLTA HPFHLRVGWA LTEGYSPYPG GGEGWGGNGV GDDLHSYGFD
     GLNLWTGRVP RQVTSPSQHI LSAEDVVSCC LDLSVPSISF RINGHPVQGM FENFNLDGLF
     FPVVSFSAGI KVRFLLGGRQ GDFKFLPPPG YAPCYEAVLP KDRLRIEPIK EYKHDNDGVR
     NLLGPTQSLS HTAFTPCPVD TVQIVLPPHL ERIREKLAEN SHELWAVTRI EQGWTYGLFR
     DDNKKLHPCL VDFQSLPDPE KSYNLAMSGE TLKTLLALGC HVGMGDEKAE ENLKKIKLPK
     TYMQCNGYKP APLDLNHVKL TPNQNTLVER LAENGHNVWA RDRVRQGWTY SIIQDIVNKR
     NPRLVPYILL DEKTKKTNRD TVCAAVRTLI GYGYNIEPPD QESSGHGGGN GRSDKIRVFR
     AEKSYAVTQG KWYFEFEAVT VGEMRVGWAR PSVHADRELG SDDLAYVFNG FKSQRWHIGN
     EPFGRQWQSG DVVGCMIDLT EQNIMFTLNG EMLISDSGSE MAFKDIEIGE GFIPVCSLGM
     SQVGRINLGQ NVSSLRYFTI CGLQEGFEPF AINMKRDITM WFSKSLPQFV PVPTDHPHIE
     VSRVDGTVES APCLKLTHRT FGSQNANTDL LFFRLSMPIE FHETFKNKGN KSNIQVFYRA
     CSHLTHQYYY SVRVFAGQEP SGVWVGWVTP DYHLYDLHFD LCKVRNVTVT VGDDKGNIHD
     SVKRSNCYMV WGGEFSSSQQ TRISQEDFVI GCLVDLDTGL MTFTANGKEI NTFYQVEPNT
     KLFPAVFCLP SSQNMLQVEL GKLKNIMPIS AAMFRSDCKN PVPQCPPRLD LQMLTPVIWS
     RMPNHFLSPE TGRVSERQGW KVQCMEPLVM MALHIPEENR CIDILELSER TDLMKFHYHT
     LKLYGSVCAL GNNRVAHALC SHVDESQLFY AIENTYLPGP IRSGYYDLLI SMHLESAKRN
     RLMTNKEFIV PMTDETRSIT LYSDAEKAHA LPGVGLTTCL RPKLHFAPTG FVGTNADLYT
     LSPMLPLQML KDHALSMLTE AVQDGGQAIR DPVGGSVEYH FVPILKLIST LLIMGVFDDD
     DVKHILKLIE PSVFSSNSET PAEETGDPEQ QLVCKEEGAE ETGAAEAEVR EEEDVGEGLL
     HMKLPESVKL QMCTLLQYFC DCELRHRVEA IIAFSDKFVN QVQTNQRQRY NELMQAFTMS
     AAETARKTRE FRSPPQEQVN MLMNFKNCPE EEDCPVPEDV RNGLLTFHHD LLAHCVGVHI
     EEEEQEEEVD TSLSGRLRRL VEKVKSLRKK PEAEPEPEED KKPSTLQELI SHTMIYWAQE
     SFIQNPELVR LMFSLLHRQY DALGELIRAL PKAYIINAVS IQDTMELLEC LGQIRSLLIV
     QMGPEEERLM IQSIGNIMSN RVFYQHPNLM RALGMHETVM EVMVNVLGGG DSKEIRFPRM
     VTNCCRFLCY FCRISRQNQR SMFDHLGYLL QNSGIGLGKP RMRGSTPLDV AAASCIDNNE
     LALALQEQDL EMVVKYLAGC GLQSCPMLLS KGYPDIGWNP VGGEKYLDFL RFAVFVNGES
     VEENANVVVR LLIRRPECFG PALRGEGGNG LLAAIEEAIK ISEDPARDGP TVKKDRRFPM
     FGGEEQHEEN RVHLGNAIMS FYSALIDLLG RCAPEMHLIQ AGKGEALRIR AILRSLVPIE
     DLVGVISLSV QIPAFGKDNS IIEPKMSASF VPDHKAPMVL FLDRVYGIDN QDFLLHVLEV
     GFLPDMRAAA SLDTAAFSTT EMALALNRYL CSAVLPLITK CAPLFAGTDH RAIMIDSMLH
     TIYRLSRGRS LTKAQRDVIE ECLMSLCRYL RPSMLQHLLR RLVFDVPILN EYAKMPLKLL
     TNHYERCWKY YCLPNGWANF GVSSEEELHL TRKLFWGIFE SLAHKKFDAE LFKIAMPCIC
     AIAGAIPPDY VDASYSSKTE KKASVDAEGN FDPKPVDTTN TIIPEKLDGF INRYAEYTHD
     RWAFEKIQNN WTFGEVMDEN AKTHPMLRPY KTFSEKDKEI YRWPIKESIK AMIAWEWTLD
     KARDGEDEKV EKKTARKISQ TAQATYDPSH GYSPQPIDIS GMTLSRELQS MAEQLAENYH
     NTWGRKKKME LQAKGGGTHP LLVPYDTLTA KEKARDREKA YELLKFLQLN GYAVTRGLKD
     MESDISSIEK RFAYGFLQKL LKWMDIAQEF IAHLEAVVSS GRVEKSPHEQ EIKFFAKILL
     PLINQYFKNH CLYFLSTPAK ILGSGGHASN KEKEMIASIF CKMSALVRHR VFLFGTDAPA
     IVNCLHILAR SLDARTVMKS GPEIVKAGLR LFFESAADDI EKMVENLKLG KVSKGNQPVK
     GVSQNINYTT TALLPVLTSL FDHIAQHQFG DDVILDDLQM SCYRIMCSIY SLGTVKTPHA
     ERHRPALGEC LAHLAAAMPV AYLEPHLNEY NAFSVYTTKT PRERAILGLP NQVQELCLDI
     PELDVLLKEI GDLAESGARY TEMPHVIEVT LPMLCNYLPR WWERGLENFP DLEGKLCTDV
     TSESLNQLLG SIMKIVVNNL GIDEASWMKR LAVFSQPIVS RAKPEMLKSH FIPTMEKLKK
     RTSKVVAEEE HLRLEGKSEG DEEEGTIRDE FAVLCRDLYA LYPLLIRYVD NNRARWLTFR
     DPDAEELFRM VGEVFIFWSK SHNFKREEQN FVVMNEINNM SFLTADSKSK MSKRPSMVRA
     GGSDVERTKK KRRGDRYSVQ TSLIVAALKK MLPIGLNMCS PADQELINLA KTRYSLKDTD
     EEVREFLQNN LHLQGKVDNP SMRWQMALYK EMAGKAEDAD APENVVKRVQ EVSAVLYHIE
     VTEHPFKSKK MVWHKLLSKQ RRRAVVACFR MTPLYNLPRH RASNMFLDGY KRNWIRNEGY
     SFEDRMIDDL SKALEEEEEE EEEKETKPDP LHQLILHFSR TALTEKSKLD IDHLYMAYAD
     IMAKSCHMDE EDEGGEEENE GGEEEMSFEE KEMEKQRLLY QQSRLHNRGA AEMVLQMISA
     CKGETGCMVS STLKLGISIL NGGNCEVQQK MLDYLKDKKD VGFFLSVQAL MQTCSVLDLN
     AFERQNKAEG LGMVSEEGTR VLKKRKCEKV MADDEFTCDL FRFLQLLCEG HNNDFQNYLR
     TQTGSTTTIN VIICTVDYLL RLQESISDFY WYYSGKDIID EPGKRNFSKA MTVAKQVFNS
     LTEYIQGPCT GNQQSLAHSR LWDAVVGFLH VFAHMMMKLA QDSSQIGLLK ELLDLQKDMV
     VMLLSLLEGN VVNGTIARQM VDMLVESSSN VEMILKFFDM FLKLKDIVAS DAFRDYVTDP
     RGLISKKDFQ KSMDSQKQYT PSEIQFLLSC SEADENEMIN YEEFASRFQE PAKDIGFNIA
     VLLTNLSEHV PHDTRLQNFL EQAESVLNYF RPFLGRIEIM GASRKIERIY FEISEVNRKQ
     WEMPQVKESK RQFIFDVVNE GGESEKMELF VNFCEDTIFE MNIASQISEQ DEEEKEEDDI
     EEAEGGDAGD EEGGGEEGQP ESSSAFADFI QSIMNFLGMF TFRNIRRKYR RLRKMTIKEI
     VVGLATFMWT ILLGILHFIY SVCKGFFLLI WHTLFGGGLV EGAKNITVTE LLASMPDPTQ
     DEVHGDLPGE PRGGEEQETG GIMDSMDAGG GEEEDEDIQE KDGGKIPGID TPGGLGDMGD
     TTPVEPPTPE GTPLLKRKAI KQKTFKYYKK KRNKENEHVF IENGEKAEKE VEVKPEPIPE
     EPKPQRATKA KKEKKSVKGA GFELWNELDV QRNKFMNCLS RNFYNIRFLA LFLAFALNFI
     LLFYKVSDTP PSSDECSAED FEGSGGEDGG DDEDEEGPVY YFLEESTGYM QPTLSFLAIL
     HTVIAFISII GYNCLKIPLV IFKREKELAR KLEFDGLYIT EQPADDDIKG QWDRLVLNTP
     SFPTNYWDKF VKRKVLDKYG DIYGRERIAE LLGMDLASLD VSKQQTDKKP EEPDNSMLAW
     FTSIDIKYQI WKFGVVFTDN TFLYLVWYTV MSLLGHYNNF FFACHLLDIA MGVKTLRTIL
     SSVTHNGKQL MMTVGLLAVV VYLYTVVAFN FFRKFYNKSE DEDEPDMKCD DMMTCYLFHM
     YVGVRAGGGI GDEIEDPAGD EYELYRVVFD ITFFFFVIVI LLAIIQGLII DAFGELRDQQ
     EQVKEDMETK CFICGIGSDY FDTTPHGFET HTLEEHNLAN YMFFLMYLIN KDETEHTGQE
     SYVWKMYQER CWDFFPAGDC FRKQYEDQLG
//
DBGET integrated database retrieval system