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Database: UniProt
Entry: A0A0R4IKT8_DANRE
LinkDB: A0A0R4IKT8_DANRE
Original site: A0A0R4IKT8_DANRE 
ID   A0A0R4IKT8_DANRE        Unreviewed;      4878 AA.
AC   A0A0R4IKT8;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   22-NOV-2017, entry version 14.
DE   SubName: Full=Ryanodine receptor 2b (cardiac) {ECO:0000313|Ensembl:ENSDARP00000134589};
GN   Name=ryr2b {ECO:0000313|Ensembl:ENSDARP00000134589,
GN   ECO:0000313|ZFIN:ZDB-GENE-061226-3};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000134589, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000134589, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000134589,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000134589}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000134589};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00448}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000134589}.
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DR   EMBL; BX323986; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX511254; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT027717; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   STRING; 7955.ENSDARP00000125063; -.
DR   Ensembl; ENSDART00000165606; ENSDARP00000134589; ENSDARG00000003706.
DR   ZFIN; ZDB-GENE-061226-3; ryr2b.
DR   GeneTree; ENSGT00760000119152; -.
DR   Proteomes; UP000000437; Chromosome 17.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR014821; Ins145_P3_rcpt.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR036300; MIR_dom_sf.
DR   InterPro; IPR016093; MIR_motif.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF08709; Ins145_P3_rec; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF02815; MIR; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00472; MIR; 4.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   SUPFAM; SSF82109; SSF82109; 2.
DR   PROSITE; PS50188; B302_SPRY; 3.
DR   PROSITE; PS50222; EF_HAND_2; 1.
DR   PROSITE; PS50919; MIR; 5.
PE   4: Predicted;
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Repeat {ECO:0000256|SAAS:SAAS00903904};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4227   4246       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4424   4444       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4481   4504       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4678   4700       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4759   4782       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN       96    151       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      158    209       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      217    272       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      278    332       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      344    401       MIR. {ECO:0000259|PROSITE:PS50919}.
FT   DOMAIN      604    802       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1023   1216       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     1342   1547       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN     3967   4002       EF-hand. {ECO:0000259|PROSITE:PS50222}.
SQ   SEQUENCE   4878 AA;  552154 MW;  87DEEB3716B94340 CRC64;
     MDIGEAEDEI QFLRTRDELV LRCCSSGPHQ QKLCLAAEGF GERLCFLEST SNSKNVPADL
     CVCVFVLDHC LSVRALQEML ANREDLCTAS HEAAGRRTLL YGQAVLFRHA YSDMYLCCLS
     TSGLSSDKLA FDVGLQEDTK GEVCWWTVHP ASKQRSEGEK VRVGDDLILV SVSSERYLHV
     SWTNGEGNDS GVGRVDAAFQ QTLWSVAPVS SGTVNTQGHV RGGDTVRLLH GHTDECLTIR
     AAKHKADQHR SVHFEGGLVS LQARSLWRLE TLHVVWSGSH IHWGQPFRLR HLTTGSFLGL
     IHDQGLQLVE RDRADVKCTA FAFRASKEIA ESLDYVKRRD GMGAPEIKYG DSLCFIQHVD
     TGLWLTYQTT DSKRQKESVS QRQAVLQAEG HMDDGITLSR SQREESKAAC LIRSSVLLFS
     QFISGLDDVT QKENITNFNL PIEIICVTLQ DLLGYFHCPE MGQDHKIRQG DIGALKNRQN
     LFQDEGIILL VLDCIDHLHV YNSAAHFAEA VGKEAGECWE GVLNAFYKLL AALIRGNRNN
     CAQFSGSLDW LVSRLERLEA SSGILEVLHC VLVESPEALN VIKESHIKTI ISLLDKHGRN
     HKILDVLCSL CVCHGMAVRS NQHLICDTLL PERDLLLQTR LINQVSSVRP NIFLCTRDDS
     AQYKKWYYEV VVEKAEPFVT AEPTHLRVGW ASTEGYRPSP TGGHDWGSNG VGDDLCSYGF
     DGLQLWTGGV GRRVSSPNQH LLREDDVISC CLDLSATCIS FRVNGQPVQG MLENFCVDGL
     LFPVVSFSAG VQVRMLFGGR QGEFRFLPPA GFSPCAEALL PKTRCKLELC HELTRNHTET
     QRDLLGPVVP ISPVTFTPVP VDSSQVEYPP QLEQIRERLA ENLHELWLID KIEQGWTYGP
     VKDEGKKVHL CLVEFSKLPD QERIHTLQSS EDILRTLLAF GVHIGLSDEH AEENVKYVRL
     SNKYELWNGY KPAPVDQSRV VLTDAQEELV EYLAENEHNI WARERIRQGW SYGPQQDVKF
     KRSTQLVPFY LLDERYKQAG RDAMRDALGT LLGFGYTVEP LEKEHASSSS VKSVGAERFR
     IFRLEQLFAV HSGKWYFEFE AVTDGEMRVG WARPGCKPDV DLGSDDQAFV FDGSKGQWWH
     GGAERLGGCW KRGDVIGCLL DLTTDTMMIT LNGEQLLNSH GSEFAVKDLI KSDGFLPVCS
     IGINQVGRLN LGCQIESLKY FNVCGLQEGY QPFGLNMSKD LPLWMSWREP LFIPIQDNHP
     NIQVVRIEGT VNNTPCLKVT KRVFGHEERG SGSVGFYRLS MPIECAQVFC GPGDASVPPS
     SAALCHLRDP EDGEVDSDFE LLMKAHRYAG SRDELNNHKD HSQEKPSRLK QRFMLKKKQE
     LNTSHSSARL LEEVLAIEKN EENRLVRCTT YYYSVRIPFS QEPSCVWVGW VTSKFSHHDV
     SFDLDRICTV TVTLGDEWGK VHESVKRSSC YMVCAAEGSS LSHSRSSNGL EIGCLVDTAT
     GLLTFTANGK EITTYYQVEP GTKLFPAVFA KATSSNVFQF ELGCIKNVMP LSAGVFRSER
     RNANPQCPPR LCVQHLTHTR WTRVPDHTQS VEMSRLEERY GWRAQCSHIQ QIMTLYIPEE
     SRCVDILELS ESHDLLKFHN HTLLLYSALS AHGNTHVSHA LCSHVDQSQL LFALQCSRMP
     GHLRTSYYNL LINIHLDAHA SARQTMNHEY IVPMTNTQSI TLYKSNEKVE RFPGSDRSTS
     LWPKMHFTSP CFIRSNNKID LVDGDEGRVL WSSLRQDSPE IPLDVLKAVV IAMLKEAVMV
     VGQGVRDPTG GSVELLLVPL LNLIHTLLLM GVYQGADLEA VFSLILPGEY MRATQRTEET
     DELGESDGGA EEKEKGDWKY DVLLQMKLPE AVKLQVCQLL KYLCDCQVRH RVEAVISFSG
     DFVGHLQEDQ RFRYNEVVDA LNMSAALTAR KTKEFRSPPQ EQINMMLSFR EDSQECPCPE
     DIQDLMWEFH QDLMSHCGIE IESGSENENE DDLSIRNHLH GLVDKIMHLK RRMSGLPEEI
     ASKPVSLQQL ISETMLHWAQ EETIEDPDLV RAVFSLLHQQ YAGLHGQMSA PLQKAYCISQ
     TSVEDTLHLQ WALACIRSLL KARMGKEEEE CMIRGLGDIM NNKVFYQHPN LMRALGMHET
     VMEVMVNVLG ARESKEIIFP KMVAHCCRFL CYFCRISRQN QKAMFDHLSY LLDNGNVGLA
     SPSMRGSTPL DVAAASVMDN NELALSLTEA DLEKVVQYLG GCGLRSCALL VSKGYPDIGW
     NPVEGERYLD FLRFAVFCNG ESVEENAYVV VRLLIRRPEC FGPALRGEGA NGLLATMEEA
     IRISNQQDGT TAHSSSRTLD TLDEDDHDVI HMGHAIMTFY SALIDLLGRC APETHLIEAG
     KGEAIRIRAI LRSLVPREDL EGIINIPFSL PVVNSDDLVV EPDMSRMFCP DHKAAMVLFL
     DRVYGVQDQQ FVLRLLKFGF LTDLKAAVNM DTTGLGGTDM ALAINRYLCV AVLPLLSKYS
     SLLCESSSSR SGPVDELLQG VYSLSKASGL TKAQREAIQD CLLAVCGKLK PSMVQPLLRN
     LVFDVPQLPE NSKMPLKLLT NHYEQSRKYY CRSYGFGDFG SASEEELCLT RRLFWGIFSA
     LAKKSYDADL FKLALGCLSA VAAAIPPDHL DLSCTGGRER HSVMDSERGF CPQPLDTLNV
     TIPESLEFVV NKYAEHTHEK WSMEKFGNGW VHGEQLSESS KVHPLLKPYR ALSEKDKECY
     RGVIKETVKC MLVLGWTIKR TNEGESHGIH NPARRISQSG KLSFEGASTF SPKPVDTSSV
     TLTWDQYAMA ERLAENYHHI WAARKLQELE SKGGGSHPLL VPYDALSVKD KSRVRDKAQD
     VLKFFHVNGY SVKRNREVAD ADSPAIASRF AYGLIQQALR LTERAQESVI ELEVAQARGQ
     INKAERVPHE QQIHFFIKVL LPLLDQYFKN HHLYFMSTTM SSLRDGCQST SKEKEMVTSL
     FCKLGSLARR RISIFGNDAL ALVNCLQILA QSLDGRMLMK TTSESVRGSI GSFFEAAAED
     LELMVENVTL DGLNRAQKRG DPELITYTTT ALIPVLSAIF QHDSQRQSGA GLILDEVQSC
     CYRILSSLYI LGTCSGSFIE RQRSVLGECL AALSAAFPVC FLELSDLHSH FDTLSNEGIE
     EKACKLLPNL HEAFLEVEEL AGAGSSARHA LLLRVTEVTL PLLCSYVSRW GEVDNQASQE
     GHCSSVTPQH ANALLGYILS IIHAHLGTSD SAWMKRLAVF GQPIINKAEP HLLKSHFLPL
     MEKLRKRAES VLLEEEHLKM EGRGDVSEQE LDIQERFTVL VQDIYAFYPL LIPFIDLHRM
     SWLREVNADA EKLFSLVAEV FIFWAKSHNF KWEEQNFVVQ NEINNMAFLV NSSKSRMNKG
     GVFCQERRKV KRKADRYSTH TSLIVAAPKK LLSVAMNGCC HGDQGLVSHA KSRFAQRDTE
     DEVRAYIHSI LQQDLCGNSV DPLRVERILS IARVLFHLDQ VEHPQKMKRP VWYKMLSKQR
     KRAVVACLRM APLYNLPRHR AVNLFLQGYE RVWLKAENDS PEDRLIEDLA KAAHVEILKE
     GAEQRNSIDP LHQLINLFSQ CALTQRSKLE EDGLYMCYAE IMAKSCQSEE EQDEDGLKSF
     EEKEMEKQRL LYQQARLHDR GAAEMILQKL SASRGDMGPM VAATLKLGIA ILNGGNTSVQ
     QKMLGYLRRK KDVGFFHSLA GLMQSCSVLD LNAFERQIKA ESLGVGAEDN SGEKVMADEQ
     LTCDLFRFLQ LLCEGHNSDF QNYLRTQTGN NTTVNIIIST VDYLLRESIS DFYWYYSGKD
     VIDERGQHNF SKAITVAKQV FNTLTEYIQG PCTGNQQSLA HSRLWDAVVG FLHVFAHMQM
     KLSRDSSQIE LLKALMDLQK DMVVMLLSML EGNVVNGTIG KQMVDMLVES SSNVEMILKF
     FDMFLKLKDL TSSEAFHEYD PDSKGLISKK DFQRAMEVFK RYSQSEIEFL LSCAEMAESE
     LLDYPDFVTR FHEPAKEIGF NMAVLLTNLS EHMPNDARLQ NFLELADSVL KYFHPHLGRI
     EILGSGKRIE RVYFEISESS RTQWEKPQVK ESKRQFIFDV VNKGGEKEKM ELFVNFCEDT
     IFEMQLAAQI SGTESGEELK AKKGKEEKEV EKTETLPEDK RMTRDLNCFS VRNIRKHIRR
     ISMKSIISVI FSLFYNVLLF ITHAFLGLLW FCLYLLYHIF LSGWIIDVAK EMKLTDLFGD
     LRDPTMVEAI GVQDAFREND NQARVFSSRG NLRGMSLDLS AVSRDPQLLT DIFGLCLKRQ
     GGKYTLSSGD HSASLDEFLN TSKYQVEIRE EDFHAVQDEE EDTETKKAFC SDEDKHNKEK
     KAKRRIRKLS SSNPDETEIQ EWAVWKMISS QKTKLLNCFA RNFYNMRLLA LFLAFAINFI
     LLFYKVSSTT DDVEIAFHDE STKSSQEVYF ELEENSGYMK MILHCLAVLH TIISLCCIIG
     YYCLKVPLVI FKREKELARK LEFDGLYITE QPSEDDIKGQ WDRMVINTPS YPSNYWDKFV
     KRKVMAKYGE LYGSARVSEL LGLDKAALDF SSGAQERKRP MQKGILFRLN TTDVKYHMWK
     LGVVFTDNSF LYLAWYMFVS VLGHYNNFFF AAHLLDIAMG FKTLRTILSS VTHNGKQLVL
     TVGLLAVVVY LYTVVAFNFF RKFYNKSEDG EPMDMKCDDM LTCYMFHMYV GVRAGGGIGD
     EIEDPAGDEF EFYRIIFDIT FFFFVIVILL AIIQGLIIDA FGELRDQQEQ VKEDMETKCF
     ICGIGNEYFD TVPHGFESHT LQEHNLANYL FFLMYLINKD VTEHTGQESY VWKMFQERCW
     EFFPVGDCFR KQYEDQLS
//
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