ID A0A0R4INZ6_DANRE Unreviewed; 178 AA.
AC A0A0R4INZ6; A0A8M2B857;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 52.
DE SubName: Full=Betacellulin, epidermal growth factor family member {ECO:0000313|Ensembl:ENSDARP00000137815, ECO:0000313|RefSeq:XP_005161232.1};
GN Name=btc {ECO:0000313|Ensembl:ENSDARP00000137815,
GN ECO:0000313|RefSeq:XP_005161232.1,
GN ECO:0000313|ZFIN:ZDB-GENE-050311-1};
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000137815};
RN [1] {ECO:0000313|Ensembl:ENSDARP00000137815, ECO:0000313|Proteomes:UP000000437}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000137815};
RX PubMed=23594743; DOI=10.1038/nature12111;
RG Genome Reference Consortium Zebrafish;
RA Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C., Muffato M.,
RA Collins J.E., Humphray S., McLaren K., Matthews L., McLaren S., Sealy I.,
RA Caccamo M., Churcher C., Scott C., Barrett J.C., Koch R., Rauch G.J.,
RA White S., Chow W., Kilian B., Quintais L.T., Guerra-Assuncao J.A., Zhou Y.,
RA Gu Y., Yen J., Vogel J.H., Eyre T., Redmond S., Banerjee R., Chi J., Fu B.,
RA Langley E., Maguire S.F., Laird G.K., Lloyd D., Kenyon E., Donaldson S.,
RA Sehra H., Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA Clee C., Oliver K., Clark R., Riddle C., Elliot D., Eliott D.,
RA Threadgold G., Harden G., Ware D., Begum S., Mortimore B., Mortimer B.,
RA Kerry G., Heath P., Phillimore B., Tracey A., Corby N., Dunn M.,
RA Johnson C., Wood J., Clark S., Pelan S., Griffiths G., Smith M.,
RA Glithero R., Howden P., Barker N., Lloyd C., Stevens C., Harley J.,
RA Holt K., Panagiotidis G., Lovell J., Beasley H., Henderson C., Gordon D.,
RA Auger K., Wright D., Collins J., Raisen C., Dyer L., Leung K.,
RA Robertson L., Ambridge K., Leongamornlert D., McGuire S., Gilderthorp R.,
RA Griffiths C., Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M.,
RA Brown J., Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA Saunders D., Wallis J., Babbage A., Hammond S., Mashreghi-Mohammadi M.,
RA Barr L., Martin S., Wray P., Ellington A., Matthews N., Ellwood M.,
RA Woodmansey R., Clark G., Cooper J., Cooper J., Tromans A., Grafham D.,
RA Skuce C., Pandian R., Andrews R., Harrison E., Kimberley A., Garnett J.,
RA Fosker N., Hall R., Garner P., Kelly D., Bird C., Palmer S., Gehring I.,
RA Berger A., Dooley C.M., Ersan-Urun Z., Eser C., Geiger H., Geisler M.,
RA Karotki L., Kirn A., Konantz J., Konantz M., Oberlander M.,
RA Rudolph-Geiger S., Teucke M., Lanz C., Raddatz G., Osoegawa K., Zhu B.,
RA Rapp A., Widaa S., Langford C., Yang F., Schuster S.C., Carter N.P.,
RA Harrow J., Ning Z., Herrero J., Searle S.M., Enright A., Geisler R.,
RA Plasterk R.H., Lee C., Westerfield M., de Jong P.J., Zon L.I.,
RA Postlethwait J.H., Nusslein-Volhard C., Hubbard T.J., Roest Crollius H.,
RA Rogers J., Stemple D.L.;
RT "The zebrafish reference genome sequence and its relationship to the human
RT genome.";
RL Nature 496:498-503(2013).
RN [2] {ECO:0000313|Ensembl:ENSDARP00000137815}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000137815};
RG Ensembl;
RL Submitted (NOV-2015) to UniProtKB.
RN [3] {ECO:0000313|RefSeq:XP_005161232.1}
RP IDENTIFICATION.
RC STRAIN=Tuebingen {ECO:0000313|RefSeq:XP_005161232.1};
RG RefSeq;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; BX649525; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CR749169; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005161232.1; XM_005161175.4.
DR STRING; 7955.ENSDARP00000136928; -.
DR PaxDb; 7955-ENSDARP00000118500; -.
DR Ensembl; ENSDART00000158471.2; ENSDARP00000136928.1; ENSDARG00000098112.2.
DR Ensembl; ENSDART00000168728.2; ENSDARP00000137815.1; ENSDARG00000098112.2.
DR Ensembl; ENSDART00000184530.1; ENSDARP00000145704.1; ENSDARG00000110368.1.
DR Ensembl; ENSDART00000185829.1; ENSDARP00000150018.1; ENSDARG00000098112.2.
DR Ensembl; ENSDART00000187759.1; ENSDARP00000157166.1; ENSDARG00000098112.2.
DR GeneID; 503869; -.
DR AGR; ZFIN:ZDB-GENE-050311-1; -.
DR CTD; 685; -.
DR ZFIN; ZDB-GENE-050311-1; btc.
DR eggNOG; ENOG502RZHQ; Eukaryota.
DR OMA; QPKRKGH; -.
DR OrthoDB; 2967388at2759; -.
DR Reactome; R-DRE-1227986; Signaling by ERBB2.
DR Reactome; R-DRE-1236394; Signaling by ERBB4.
DR Reactome; R-DRE-1250196; SHC1 events in ERBB2 signaling.
DR Reactome; R-DRE-1250342; PI3K events in ERBB4 signaling.
DR Reactome; R-DRE-1250347; SHC1 events in ERBB4 signaling.
DR Reactome; R-DRE-1257604; PIP3 activates AKT signaling.
DR Reactome; R-DRE-177929; Signaling by EGFR.
DR Reactome; R-DRE-179812; GRB2 events in EGFR signaling.
DR Reactome; R-DRE-180292; GAB1 signalosome.
DR Reactome; R-DRE-180336; SHC1 events in EGFR signaling.
DR Reactome; R-DRE-182971; EGFR downregulation.
DR Reactome; R-DRE-1963640; GRB2 events in ERBB2 signaling.
DR Reactome; R-DRE-1963642; PI3K events in ERBB2 signaling.
DR Reactome; R-DRE-212718; EGFR interacts with phospholipase C-gamma.
DR Reactome; R-DRE-5673001; RAF/MAP kinase cascade.
DR Reactome; R-DRE-6785631; ERBB2 Regulates Cell Motility.
DR Reactome; R-DRE-6811558; PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling.
DR Reactome; R-DRE-8847993; ERBB2 Activates PTK6 Signaling.
DR Reactome; R-DRE-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-DRE-8856828; Clathrin-mediated endocytosis.
DR Reactome; R-DRE-8863795; Downregulation of ERBB2 signaling.
DR Proteomes; UP000000437; Chromosome 21.
DR Bgee; ENSDARG00000098112; Expressed in swim bladder and 19 other cell types or tissues.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005154; F:epidermal growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0048856; P:anatomical structure development; IEA:UniProt.
DR GO; GO:0007173; P:epidermal growth factor receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IBA:GO_Central.
DR GO; GO:0045840; P:positive regulation of mitotic nuclear division; IBA:GO_Central.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR InterPro; IPR000742; EGF-like_dom.
DR PANTHER; PTHR10740:SF3; PROBETACELLULIN; 1.
DR PANTHER; PTHR10740; TRANSFORMING GROWTH FACTOR ALPHA; 1.
DR PRINTS; PR00009; EGFTGF.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50026; EGF_3; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|PROSITE-ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|PROSITE-ProRule:PRU00076};
KW Growth factor {ECO:0000256|ARBA:ARBA00023030};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW Signal {ECO:0000256|SAM:SignalP}; Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..23
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 24..178
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5015044273"
FT TRANSMEM 113..137
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 59..99
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 151..178
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 89..98
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 178 AA; 20325 MW; F3BAFA5279D222C3 CRC64;
MDRTRRFIFA IISAVVLCKH SQAEWNATKA PANRTVSCEH HANSSNCTDS KDEQKWSGHF
SACPKEYKHF CIHGVCRFIE EQNTPSCRCE KGYIGSRCEY LDIDFHVGER RKIVIACVVA
GLVFLILLIV FICVCTHKRY RPCRKKKRKK QTIDEDDKHT PLNAHEGVPA DTSNTNAV
//
