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Database: UniProt
Entry: A0A0R4IQC4_DANRE
LinkDB: A0A0R4IQC4_DANRE
Original site: A0A0R4IQC4_DANRE 
ID   A0A0R4IQC4_DANRE        Unreviewed;      1830 AA.
AC   A0A0R4IQC4;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   10-MAY-2017, entry version 12.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=scn4aa {ECO:0000313|Ensembl:ENSDARP00000136666,
GN   ECO:0000313|ZFIN:ZDB-GENE-051201-2};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000136666, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000136666, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136666,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000136666}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136666};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000136666}.
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DR   EMBL; BX323464; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000165478; ENSDARP00000136666; ENSDARG00000098738.
DR   ZFIN; ZDB-GENE-051201-2; scn4aa.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; FTIVEHD; -.
DR   Proteomes; UP000000437; Chromosome 12.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    120    142       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    187    206       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    218    239       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    245    265       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    389    416       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    582    600       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    612    635       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    647    671       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    692    720       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    782    805       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    997   1015       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1036   1054       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1074   1093       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1113   1139       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1237   1260       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1321   1339       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1351   1369       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1381   1401       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1438   1466       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1542   1565       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      124    422       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      583    809       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      819    990       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      995   1268       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1320   1575       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED      413    447       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1830 AA;  207997 MW;  0DDC693111ED2D70 CRC64;
     MARLLPPTGT SVFRRFTPES LVEIERLIQE KSTREELEGA EEEPQAPSSD LEAGKCLPMI
     YGDPPGDLLN TPLEDIDPFY KTQKTFIVIS KGNTIFRFSS EPAMFCISPF SIVRRGAIKI
     LIHSFFMFIM ITILSNCVFM TMSNPPAWSK TVEYVFTGIY TFEATVKVLS RGFCIGPFTF
     LRDPWNWLDF MVISMAYVTE FVDLGNVSAL RTFRVLRALK TITVIPGLKT IVGALIQSVK
     KMIDVMILTI FALAVFALIG LQLFMGNLRQ KCIRWPILNS TIFDVYNSNM VNDTTLNVTD
     TFDFKAYISN EENQYFLEGS LDALLCGNSS DAGRCPEGYT CMKAGRNPNY GYTSYDNFGW
     AFLALFRLMT QDFWENLFQL TLRAAGKTYM IFFVVVIFLG SFYLINLILA VVAMAYDEQN
     EATLAEARDK EEEFQRLLEQ LKNQETGSKA SLASQKTQSR GSNRTGSLHD LADEDVIKDC
     NGRIVPRLIV NRVSSNKELS AEEDQKSLSS KHSMQYLDQP KLSKRTASAL SVLTATMEGL
     EDAQRPCPPG WYKFADMFLK WDCCAPWILF KKWVHFVVMD PFVDLGITIC IVLNTLFMAM
     EHYPMSPHFE HVLSVGNLVF TGIFTAEMVF KLIAMDPYYY FQVGWNIFDS IIVTLSLVEL
     GLANVQGLSV LRSFRLLRVF KLAKSWPTLN MLIKIIGNSV GALGNLTLVL AIIVFIFAVV
     GMQLFGKSYK DCVCKISEDC ELPRWHMNDF FHSFLIVFRI LCGEWIETMW DCMEVAGASM
     CLIVFMMVMV IGNLVVLNLF LALLLSSFSG DNLSGGDDDG EMNNLQIAIG RITRGIDWVK
     ALVASMVQRI LGKKPDNTKE EGEGDIELYA LNHLDEGKMA DGLTNCLSPT LTVPIARCES
     DVEEDEDSES SDEEDAKATL NDGDSSVCST VDYQPPEPEP EPEEVEEEEP EPEEPEACFT
     EGCIRRCACL SVDITEGWGK KWWNLRRTCF TIVEHDYFET FIIFMILLSS GALAFEDINI
     ERRRVIKTIL EYADKVFTYI FIVEMLLKWV AYGFKTYFTN AWCWLDFLIV DVSLVSLTAN
     LMGYSELGAI KSLRTLRALR PLRALSRFEG MRVVVNALVG AIPSIFNVLL VCLIFWLIFS
     IMGVNLFAGK FYHCINTTTE ERIPMDVVNN KSDCMALMYT NEVRWVNVKV NYDNVGLGYL
     SLLQIATFKG WMDIMYAAVD SREVDEQPSY EINLYMYLYF VIFIIFGSFF TLNLFIGVII
     DNFNQQKSKI SIFFKDIFMT EEQKKYYNAM KKLGAKKRPK PIPRPSNIIQ GLVFDFISKQ
     FFDIFIMVLI CLNMVTMMIE TDDQSAEKEY VLYQINLVFI VVFTSECVLK LFALRQYFFT
     IGWNVFDFVV VILSIAGLML SDIIEKYFVS PTLFRVIRLA RIGRVLRLIR GAKGIRTLLF
     ALMMSLPALF NIGLLLFLIM FIFSIFGMSN FAYVKKQAGI DDIFNFETFG GSIICLFEIT
     TSAGWDGLLL PILNSGPPDC DPDFENPGTD VRGNCGNPGM GIMFFCSYII MSFLVVVNMY
     IAIILENFNN AQEESGDPLC EDDFDMFDET WEKFDVDATQ FIEYDRLFDF VDALQEPLRI
     AKPNRLKLIS MDIPIVNGDK IHSQDILLAV TREVLGDTIE MDAMKESIEA KFIMNNPTSA
     SFEPIITTLR RKEEERAAIA VQRIYRRHLL KRAIRYACFM RQSKRKVRNP NDNEPPETEG
     LIARKMNTLY GSNPELAMAL ELETRPMRPN SQPPKPSQVT QTRASVTFPR PQGQLILPVE
     LTSEVILRSA PTTHSFNSSE NATTIKESIV
//
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