GenomeNet

Database: UniProt
Entry: A0A0R4IQE3_DANRE
LinkDB: A0A0R4IQE3_DANRE
Original site: A0A0R4IQE3_DANRE 
ID   A0A0R4IQE3_DANRE        Unreviewed;      4596 AA.
AC   A0A0R4IQE3;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   20-DEC-2017, entry version 15.
DE   SubName: Full=Ryanodine receptor 1b (skeletal) {ECO:0000313|Ensembl:ENSDARP00000136778};
DE   Flags: Fragment;
GN   Name=ryr1b {ECO:0000313|Ensembl:ENSDARP00000136778,
GN   ECO:0000313|ZFIN:ZDB-GENE-070705-417};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000136778, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000136778, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136778,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000136778}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000136778};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000136778}.
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DR   EMBL; CABZ01017258; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01017259; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CABZ01062181; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CR377223; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CT025746; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CU138549; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; FQ311881; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000169963; ENSDARP00000136778; ENSDARG00000023797.
DR   ZFIN; ZDB-GENE-070705-417; ryr1b.
DR   GeneTree; ENSGT00760000119152; -.
DR   Reactome; R-DRE-2672351; Stimuli-sensing channels.
DR   Reactome; R-DRE-5578775; Ion homeostasis.
DR   Proteomes; UP000000437; Chromosome 18.
DR   ExpressionAtlas; A0A0R4IQE3; baseline.
DR   GO; GO:0005623; C:cell; IEA:GOC.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR   GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IMP:ZFIN.
DR   GO; GO:0034599; P:cellular response to oxidative stress; IMP:ZFIN.
DR   GO; GO:0031443; P:fast-twitch skeletal muscle fiber contraction; IMP:ZFIN.
DR   GO; GO:0008345; P:larval locomotory behavior; IMP:ZFIN.
DR   CDD; cd12877; SPRY1_RyR; 1.
DR   CDD; cd12878; SPRY2_RyR; 1.
DR   CDD; cd12879; SPRY3_RyR; 1.
DR   Gene3D; 1.25.10.30; -; 2.
DR   InterPro; IPR001870; B30.2/SPRY.
DR   InterPro; IPR013320; ConA-like_dom_sf.
DR   InterPro; IPR011992; EF-hand-dom_pair.
DR   InterPro; IPR002048; EF_hand_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR035910; IP3R_RIH_dom_sf.
DR   InterPro; IPR013662; RIH_assoc-dom.
DR   InterPro; IPR000699; RIH_dom.
DR   InterPro; IPR013333; Ryan_recept.
DR   InterPro; IPR003032; Ryanodine_rcpt.
DR   InterPro; IPR015925; Ryanodine_recept-rel.
DR   InterPro; IPR009460; Ryanrecept_TM4-6.
DR   InterPro; IPR035761; SPRY1_RyR.
DR   InterPro; IPR035764; SPRY2_RyR.
DR   InterPro; IPR035762; SPRY3_RyR.
DR   InterPro; IPR003877; SPRY_dom.
DR   PANTHER; PTHR13715; PTHR13715; 1.
DR   Pfam; PF13833; EF-hand_8; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08454; RIH_assoc; 1.
DR   Pfam; PF06459; RR_TM4-6; 1.
DR   Pfam; PF01365; RYDR_ITPR; 2.
DR   Pfam; PF02026; RyR; 4.
DR   Pfam; PF00622; SPRY; 3.
DR   PRINTS; PR00795; RYANODINER.
DR   SMART; SM00449; SPRY; 3.
DR   SUPFAM; SSF100909; SSF100909; 1.
DR   SUPFAM; SSF47473; SSF47473; 1.
DR   SUPFAM; SSF49899; SSF49899; 3.
DR   PROSITE; PS50188; B302_SPRY; 3.
PE   1: Evidence at protein level;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Proteomics identification {ECO:0000213|PeptideAtlas:A0A0R4IQE3};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   3863   3886       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4099   4119       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4200   4222       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4348   4376       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4396   4418       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   4477   4500       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN      108    318       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      534    730       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   DOMAIN      864   1075       B30.2/SPRY. {ECO:0000259|PROSITE:
FT                                PS50188}.
FT   COILED     1405   1432       {ECO:0000256|SAM:Coils}.
FT   COILED     1442   1462       {ECO:0000256|SAM:Coils}.
FT   COILED     2457   2477       {ECO:0000256|SAM:Coils}.
FT   COILED     3205   3232       {ECO:0000256|SAM:Coils}.
FT   COILED     3784   3804       {ECO:0000256|SAM:Coils}.
FT   COILED     4052   4074       {ECO:0000256|SAM:Coils}.
FT   NON_TER       1      1       {ECO:0000313|Ensembl:ENSDARP00000136778}.
SQ   SEQUENCE   4596 AA;  521048 MW;  CDE7F7BF15971C44 CRC64;
     XGMITIVLEC IDRLNVYNTA AHFSEFAGEE AAESWKEIVN LLYELLASLI RGNRSNCALF
     CDNLDWLVSK LDRLEASSGI LEVLYCVLIE SPEVLNIIQE NHIKSIISLL DKHGRNHKVL
     DVLRSLCVCN GVAVRSNQNL ITENLLPGRD LLLQTNIVNY ASSVRPNIFL GTCEGSTQYK
     KWYFEVMVDY VESFVTAQAT HLRVGWAMTE GFSPYPGGGE GWGGNGVGDD LYSYGFDGLH
     LWSGHVSRQV ASPNQHALAA DDVVSCCLDL SVPSISFRIN GHPVQGMFEN FNLDGLFFPA
     ISFSAGVKAR FLLGGRHGDF KFLPPPGYAP CYEALLPKDR MRIEPIKEYK HDFEGVRNLL
     GPTQSLTHTS FTPCPVDTAQ IVLPPHLERI REKLAENIHE LWAVTRIEQG WTYGVFRDDN
     KKLHPCLVDF QSLPEPERNY NLQMSGETLK TLLALGCHVG MGDEKAEENL RKIKLPKTYV
     MSSGYKPAPL DLNHVKLTPN QNQLVEKLAE NGHNVWARDR VRQGWTYSIV QDIVNKRNPR
     LVPYNLLDER TKKTNRDSVN NAVRTLIGYG YNIEPPDQES SGHGVEDVHG DKVRIFRAEK
     QYGVTSGKWY FEFEAVTTGE MRVGWARPNV RSDVELGSDE LAYVFNGNRA QRWHIGNDPF
     GRQWQSGDVV GCMIDLIEMN IMFTLNGEML ISDSGSEMAF KDIEIGDGFI PVCTLGLSQV
     GRINLGQNVS SLRYFAICGL QEGFEPFAIN MKRDITMWFS KSLPQFVPVP TDHNHIEVSR
     VDGTVDSAPC IKITHKTFGS QNANTDMLFF RLSMPVEFHL TFKVPAGTTP LTRALTIPEE
     EVLEVDPDSD YEVLKKSASR KEQEEKEKEP SVPKDIPGVK ENDKDTASEK GKKKGFLFKA
     KKAAMITPPP PPPLMPRLIE DVVPDDRDDV DIILNTTTYY YSVRIFAGQE PSEVWVGWVT
     PDFHMYDLNF DLSKVRTVTV TVGDDKGNIH DSIKRSNCYM VWGGEFSSSQ QKFSQEDLVI
     GCLVDLATGL LNFTANGKEI NTFYQVEPNT KLFPAVFVLP SSQNMLQLEL GKLKNIMPLS
     AAMFRSERKN PVPQCPPRLD VQMLTPVIWS RMPNHFLNPV VGRVSERHGW MVECTEPLTM
     MALHIPEENR CIDILELSEQ HDLLQFHYHT LMLYCAVCAL GNNRVAHALC SHVDESQLFY
     AIENTYLPGP LRSGYYDLLI SIHLESAKRN RLGTNREFIV PMTSETLSIT LFPDAEAAHD
     LPGVGLTTCL RPKLHFSPIN FVGTDPDLYT LSPIIPLQNL KTQALSMLTE AVFDGSQAMR
     DPVGGSVEFH FVPILKLIST LLIMGIFNNE DVKHILKMID PSVFGKKEEA EEPAEEAAPK
     EEGEEVKEKE ETAEGEEEAV DEGVGEEEEE ELKELKKEEG EEGEEVEKAV EEEDGEKVDG
     EKAEEEKEAE EVGEEAKEEE EEAPEEGLLQ MKMPESVKLQ MCTLLQYFCD CELRHRVEAI
     MAYSDNFVGQ IQSNQRERYN ELMRAFTMSA AETARRTREF RSPPQEQIFL LTNFKHNPEE
     EDCPVPDEVR ETHNNFHNDL LNHCGVHIEE EVEEEEVDTS LRGRLLTLVD KVKSLKQKKE
     EEEPEPEEEP KPSTLQELIS HTMIHWAQEA FIQNPELVRL MFSLLHRQYD ALGELIRALP
     KAYAISAVSV QDTMEMLECL GQIRSLLIVQ MGPEEERLMI QSIGNIMNNK VFYQHPNLMR
     ALGMHETVME VMVNVLGGGG DSKEIRFPQM VTNCCRFLCY FCRISRQNQR SMFDHLSYLL
     QNSGIGLGMR GSTPLDVAAA SCIDNNELAL ALQEQDLEMV VTYLAGCGLR MCPMLLSKGY
     PDIGWNPGGG ERYLDFLRFA VFVNGESVEE NANVVVRLLI RRPECFGPAL RGEGGAGLLA
     AIEEAIKISE DPARDGPTPK KDRRFMFGGE DQHEENRLHL GNAIMSFYSA LIDLLGRCAP
     EMHLIQAGKG EALRIRAILR SLVPIEDLVG VISLPVQIPT FGKDGQIVEP KMSASFVPDH
     KASMVLFLDR VYGIDNQDFL LHVLEVGFLP DMRASASLDT VAFSTTEMAL ALNRYLCSAV
     LPLLTKCAPL FAGTDHRAIM IDSMLHTIYR LSRGRALTKA QRDVIEDCLM SLVKYLRPSM
     LQHLLRRLVF DVPILNEYAK MPLKLLTNHY ERCWKYYCLP NGWANFGVTS EEELHLSRKL
     FWGIFESLAH KKFDAELFKI AMPCICAIAG AIPPDYVDAS YSSMTEKKAS VDAEGNFDPK
     PVETTNTIIP ERLDAFINKY AEHTHDKWAF EKIQNNWTYG EVLDENAKTH PMLRPYKTFS
     EKDKEIYRWP IKESIKAMLA WEWTLEKARD GETEVKTEVK ATRKISQTAQ ATYDPSQGYS
     PQPVDLIGMA LSRELQSMAE QLAENYHNTW GRKKKMELQA KGGGTHPLLV PYDTLTAKEK
     ARDREKAQDL LKFLQLNGYA VTRGLKDMEQ EISSIEKRFA YGFLQKLLKW MEIAQEFIAH
     LEAVVSSGRV EKSPHEQEIK FFAKILLPLI NQYFKNHCLY FLSTPAKVLG SGGHASNKEK
     EMIASIFCKL AGLVRHRVSL FGTDASAVVN CLHILSRSLD ARTVMKSGPE IVKAGLRSFF
     ESAADDIEKM VENLKLGKVS TKNQVKGVSQ NISYTTTALL PVLTSLFDHI AQHQFGDDVM
     LDDLQISCYR IMCSIYSLGT VKTPHAENQR PALGECLAHL AAAMPVAFLE PNLNEFNSYS
     VYTTKTPRER TILGLPSQVQ ELCLDIPELD VLMKEIGHLA ESGARYTEMP HVIEITLPML
     CNYLPRWWER GPENFPEQEG CLCTDVTSEQ LNQLLGSIMK IVVNNLGIDE ASWMKRLAVF
     AQPIVSRAKP EMLKSHFIPT MEKLKKRSGK VVAEEEQLRM EGKTEVDSEG GTIRDEFAVL
     CRDLYALYPL LIRYVDNNRA RWLTCPDPDA EDLFRMVGEV FIFWSKSHNF KREEQNFVVM
     NEINNMSFLT ADSKSKMSKA GDGEGGGSDD DRTKKKRRGD RYSVQTSLIV AALKKLLPIG
     LNMCSPADQE LINLAKIRYS LKDTDEEVRE FLQNNLHLQG KVEDPSMRWQ MALYKETSGK
     AEDADAPEKV VKRVQEVSAV LYHLELTEHP YKSKKMVWHK LLSKQRRRAV VACFRMTPLY
     NIPRHRASNM FLDGYKRNWL ENEGYSFEDK MIDDLSKALE QEEEEEEETE SKPDPLHQLI
     LHFSRTALTE KLKLEVDHLY MSYADIMAKS CHIGEEDEGG EEGGVEPSFE VRQTEMEKEM
     EKQRLLYQQS RLHDRGAAEM VLQMISACKG ETGVMVSSTL KLGISILNGG NSDVQQRMLD
     YLKDKKDVGF FLSLQALMQT CSVLDLNAFE RQNKAEGLGM VSEEGTKEKV MADDEFTCDL
     FRFLQLLCEG HNNDFQNYLR TQTGSTTTIN IIICTVDFLL RLQESISDFY WYYSGKDIID
     EPGKRNFSKA MTVAKQVFNS LTEYIQGPCT GNQQSLAHSR LWDAVVGFLH VFAHMMMKLA
     QDSSQIGLLK ELLDLQKDMV VMLLSLLEGN VVNGTIARQM VDMLVESSSN VEMILKFFDM
     FLKLKDIVAS DAFRDYVTDP RGLISKKDFS KAMDSQKQYT PSEIQFLLSC SEADENEMIN
     FEEFANRFQE PAKDIGFNIA VLLTNLSEHV PHDTRLQNFL EQAESVLNYF RPFLGRIEIM
     GASKRIERIY FEISEANRNQ WEMPQVRESK RQFIFDVVNE GGESEKMELF VNFCEDTIFE
     MNIASQISEQ EEEVIEDEDE EEEEESGGGG GGEGEGEEGN GEEAPPESSS AFADFIKSIV
     NFLSLFTFRN LRRRYRKIRK MTIKDMIVGL VMFLYTVLFG ILHFIYSVCK GFFLLIWNTL
     FGGGLVEGAK KMTLTEILTN MPDPTQDEVH GDLPPEPGAR KVQEAGGAGE GEEGAGGGEE
     EAEEGEEDED GRAGFGPHGG LGDMGETEPE EPPTPEGSPL LKRKLVSEEG VEGEVVVEEE
     KVEEEPAPEP EKADAENGEK EKEAEPETED KQEEEQAEIA KAKAKAKKGK KEEEVGFELW
     NELEIQRIKF MNYLSRNFYN LRFLALFIAF ALNFILLFYK VSDRLPGEEE EFEGSAMFEG
     SGAFEGSAVF EGSAVFEGSG VFEGSGEAEG SGMEENGEED EENGFVYYFL EESTGYMEPA
     MAFFSILHTI ISFLCIIGYN CLKVPLVIFK REKELARKLE FDGLYVTEQP EDDDIKGQWD
     RLVLNTPSFP NNYWDKFVKR KVLEKYGDIY GRERIAELLG MDLASLDVSA MTHEKKRQPD
     PSMFTWLTSI DIKYQIWKFG VVFTDNTFLY LVWYTVMSLL GHFNNFFFAC HLLDIAMGVK
     TLRTILSSVT HNGKQLLMTV GLLAVVVYLY TVVAFNFFRK FYNMSEDEDE PDMKCDDMMT
     CYLFHMYVGV RAGGGIGDEI EDPAGDEYEL YRVVFDITFF FFVIVILLAI IQGLIIDAFG
     ELRDQQEQVR EDMETKCFIC GIGSDYFDST PHGFETHTME EHNLANYMFF LMYLINKDET
     EHTGQESYVW KMYQERCWDF FPAGDCFRKQ YEDQLG
//
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