GenomeNet

Database: UniProt
Entry: A0A0R4IX17_DANRE
LinkDB: A0A0R4IX17_DANRE
Original site: A0A0R4IX17_DANRE 
ID   A0A0R4IX17_DANRE        Unreviewed;      1785 AA.
AC   A0A0R4IX17;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 15.
DE   RecName: Full=Sodium channel protein {ECO:0000256|RuleBase:RU361132};
GN   Name=scn4ab {ECO:0000313|Ensembl:ENSDARP00000140995,
GN   ECO:0000313|ZFIN:ZDB-GENE-051201-1};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000140995, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000140995, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000140995,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000140995}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000140995};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- FUNCTION: Mediates the voltage-dependent sodium ion permeability
CC       of excitable membranes. {ECO:0000256|RuleBase:RU361132}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane
CC       {ECO:0000256|RuleBase:RU361132}; Multi-pass membrane protein
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- SIMILARITY: Belongs to the sodium channel (TC 1.A.1.10) family.
CC       {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: Lacks conserved residue(s) required for the propagation
CC       of feature annotation. {ECO:0000256|RuleBase:RU361132}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000140995}.
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DR   EMBL; BX005440; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000168970; ENSDARP00000140995; ENSDARG00000034588.
DR   ZFIN; ZDB-GENE-051201-1; scn4ab.
DR   GeneTree; ENSGT00830000128242; -.
DR   OMA; GNDTWYG; -.
DR   Proteomes; UP000000437; Chromosome 3.
DR   ExpressionAtlas; A0A0R4IX17; baseline.
DR   GO; GO:0001518; C:voltage-gated sodium channel complex; IEA:UniProtKB-UniRule.
DR   GO; GO:0005248; F:voltage-gated sodium channel activity; IEA:InterPro.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR   InterPro; IPR028817; Na_channel_a4suB.
DR   InterPro; IPR001696; Na_channel_asu.
DR   InterPro; IPR010526; Na_trans_assoc.
DR   PANTHER; PTHR10037:SF186; PTHR10037:SF186; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   Pfam; PF06512; Na_trans_assoc; 1.
DR   PRINTS; PR00170; NACHANNEL.
DR   PROSITE; PS50096; IQ; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|RuleBase:RU361132};
KW   Ion transport {ECO:0000256|RuleBase:RU361132};
KW   Membrane {ECO:0000256|RuleBase:RU361132};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Sodium {ECO:0000256|RuleBase:RU361132};
KW   Sodium channel {ECO:0000256|RuleBase:RU361132};
KW   Sodium transport {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane {ECO:0000256|RuleBase:RU361132};
KW   Transmembrane helix {ECO:0000256|RuleBase:RU361132};
KW   Transport {ECO:0000256|RuleBase:RU361132};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    131    150       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    195    214       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    226    247       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    253    273       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    399    426       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    561    588       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    600    623       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    680    713       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    733    750       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    770    793       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM    973    992       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1013   1031       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1051   1070       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1091   1117       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1215   1239       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1298   1316       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1328   1346       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1358   1378       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1415   1443       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   TRANSMEM   1514   1541       Helical. {ECO:0000256|RuleBase:RU361132}.
FT   DOMAIN      133    433       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      571    797       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN      807    967       Na_trans_assoc. {ECO:0000259|Pfam:
FT                                PF06512}.
FT   DOMAIN      972   1247       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   DOMAIN     1297   1551       Ion_trans. {ECO:0000259|Pfam:PF00520}.
FT   COILED       21     49       {ECO:0000256|SAM:Coils}.
FT   COILED      423    458       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   1785 AA;  201939 MW;  FA71D5FE0A766D60 CRC64;
     MARLLPPTGT DVFRPLTLES LAEIDRRMAE EAAEQERMKE QNVKVAEEDL PKPTSDLEAG
     KVLPFIYGDP PPNLLNVPIE ELDPYYKAQK TFIVIDKKNT IYRFNTEPAC YCLSPFNPVR
     RAAIRILIHS YPIHLVIMLT ILTNCVFMAM SDPPGWSKIL EYVFTGIYTF EAMVKVLSRG
     FCIGDFTFLR DPWNWLDFMV ISMAYLTEFV DLGNISALRT FRVLRALKTI TVIPGLKTIV
     GALIQSVKKL ADVMILTVFC LSVFALIGLQ LFMGNLRQKC VLWPPVGWYS DNLTVLSNYT
     DINGNGTANS TFDYQKYINS EENYYYVPGQ MDPLVCGNSS DAGLCPEGYI CLKAGRNPNY
     GYTSYDNFGW AFLALFRLMT QDFWENLFQL TLRAAGKTYM IFFVVIIFLG SFYLINLILA
     VVAMAYAEQN EATAAEAKEK EEEYAKIMEQ LKKQAEQKNG MVNGSKTSLS SKKKGDNDQM
     QSDYDGIALK PLSKSNGSKG NINYLEVPDS QIRKPSVVSA VESALDAQED IERPCPPGWY
     KFADIFLKWD CCIPWVKFKR IVYLFVMDPF VDLGITLCIV LNTVFMAMEH YPMSVHVEEV
     LAIGNLVFTG IFAAEMVLKL IALDPYYYFQ VGWNIFDSII VTMSLVELML ADVEGLSVLR
     SFRLMRVFKL AKSWPTLNML IKIIGNSVGA LGNLTLVLAI IVFIFAVVGM QLFGKSYTDS
     VCKISSDCEL PRWHMADFFH AFLIIFRVLC GEWIETMWDC MEVAGQGMCI IVFMMVMVIG
     NLVVLNLFLA LLLSSFSGDN LSASDDDGEN NLQIAISRIT RGIDWIKAFV NKHVRQCLNL
     KPKEEGAKVN GEGDAKMNAI MNSSSSMVKV PIANGESDDD DGNGSSEDED DEGRDINMKK
     KNGDESSTCS TVDKPPEVED LVEEEEEDLT SPEDCYTENC IRRCPCLDLD VSQGKGKAWW
     NFRKTCFAIV EHSYFETFII FMILLSSGAL AFEDIYIEQR RMIKIILEYA DQVFTYVFVV
     EMLLKWVAYG FKVYFTNAWC WLDFLIVDVS LISLTANILG YSELGAIKSL RTLRALRPLR
     ALSRFEGMRI VVVNALVGAI PSIFNVLLVC LIFWLIFSIM GVNLFAGKFY YCFNETSEEV
     FDHNVVNNKT DCYELMEFHP EVRWMNGKIN FDNVGMGYLA LLQVATFKGW MDIMYSAVDS
     RAIESQPVYE ANLYMYIYFV IFIIFGSFFT LNLFIGVIID NFNQQKAKIR GTDIFMTEEQ
     KKYYNAMKKL GSKKPQKPIP RPTNCCQGLV FDFVTQQFFD IFIMVMICLN MVTMMVETDD
     QSAEIEEILF YINFAFIILF TGECVLKITA LRYHYFSIGW NIFDFVVVIL SILGIGLADL
     IEKYFVSPTL FRVIRLARIG RVLRLIRGAK GIRTLLFALM MSLPALFNIG LLLFLIMFIF
     SIFGMSNFAY VKKEVGIDDM MNFETFGNSI ICMFMITTSA GWDGLLAPIL NSPPDCDPDV
     DNPGSTTRGN CGNAAVGIVF FCSYIVMSFL VVVNMYIAII LENFNVATEE SSDPLCEDDF
     EMFYETWEKF DPTASQFIDY NRLSEFCDTL KDPLRIPKPN TLKLITMDIP MVTGDKIHCL
     DLLLALTGEV LGGSDQMDGM KATMEEKFMA NNPSKASYEP ITSTLKRKQE EVAASTIQRA
     YRSHILKRCV KQASYMYRDK TGSKKPTGEA PEKVGMIAEN MRSLYGDQAV EDDHPVGCSF
     SQHGKTQFGA KRPPVKVQSD VVLHSAPFPV PESSTAADNL RESIV
//
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