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Database: UniProt
Entry: A0A0R4IYM2_DANRE
LinkDB: A0A0R4IYM2_DANRE
Original site: A0A0R4IYM2_DANRE 
ID   A0A0R4IYM2_DANRE        Unreviewed;      2295 AA.
AC   A0A0R4IYM2;
DT   20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT   20-JAN-2016, sequence version 1.
DT   25-OCT-2017, entry version 13.
DE   RecName: Full=Voltage-dependent N-type calcium channel subunit alpha {ECO:0000256|RuleBase:RU003808};
GN   Name=cacna1ba {ECO:0000313|Ensembl:ENSDARP00000141982,
GN   ECO:0000313|ZFIN:ZDB-GENE-060531-44};
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Cyprinidae; Danio.
OX   NCBI_TaxID=7955 {ECO:0000313|Ensembl:ENSDARP00000141982, ECO:0000313|Proteomes:UP000000437};
RN   [1] {ECO:0000313|Ensembl:ENSDARP00000141982, ECO:0000313|Proteomes:UP000000437}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000141982,
RC   ECO:0000313|Proteomes:UP000000437};
RX   PubMed=23594743; DOI=10.1038/nature12111;
RA   Howe K., Clark M.D., Torroja C.F., Torrance J., Berthelot C.,
RA   Muffato M., Collins J.E., Humphray S., McLaren K., Matthews L.,
RA   McLaren S., Sealy I., Caccamo M., Churcher C., Scott C., Barrett J.C.,
RA   Koch R., Rauch G.J., White S., Chow W., Kilian B., Quintais L.T.,
RA   Guerra-Assuncao J.A., Zhou Y., Gu Y., Yen J., Vogel J.H., Eyre T.,
RA   Redmond S., Banerjee R., Chi J., Fu B., Langley E., Maguire S.F.,
RA   Laird G.K., Lloyd D., Kenyon E., Donaldson S., Sehra H.,
RA   Almeida-King J., Loveland J., Trevanion S., Jones M., Quail M.,
RA   Willey D., Hunt A., Burton J., Sims S., McLay K., Plumb B., Davis J.,
RA   Clee C., Oliver K., Clark R., Riddle C., Elliot D., Threadgold G.,
RA   Harden G., Ware D., Begum S., Mortimore B., Kerry G., Heath P.,
RA   Phillimore B., Tracey A., Corby N., Dunn M., Johnson C., Wood J.,
RA   Clark S., Pelan S., Griffiths G., Smith M., Glithero R., Howden P.,
RA   Barker N., Lloyd C., Stevens C., Harley J., Holt K., Panagiotidis G.,
RA   Lovell J., Beasley H., Henderson C., Gordon D., Auger K., Wright D.,
RA   Collins J., Raisen C., Dyer L., Leung K., Robertson L., Ambridge K.,
RA   Leongamornlert D., McGuire S., Gilderthorp R., Griffiths C.,
RA   Manthravadi D., Nichol S., Barker G., Whitehead S., Kay M., Brown J.,
RA   Murnane C., Gray E., Humphries M., Sycamore N., Barker D.,
RA   Saunders D., Wallis J., Babbage A., Hammond S.,
RA   Mashreghi-Mohammadi M., Barr L., Martin S., Wray P., Ellington A.,
RA   Matthews N., Ellwood M., Woodmansey R., Clark G., Cooper J.,
RA   Tromans A., Grafham D., Skuce C., Pandian R., Andrews R., Harrison E.,
RA   Kimberley A., Garnett J., Fosker N., Hall R., Garner P., Kelly D.,
RA   Bird C., Palmer S., Gehring I., Berger A., Dooley C.M., Ersan-Urun Z.,
RA   Eser C., Geiger H., Geisler M., Karotki L., Kirn A., Konantz J.,
RA   Konantz M., Oberlander M., Rudolph-Geiger S., Teucke M., Lanz C.,
RA   Raddatz G., Osoegawa K., Zhu B., Rapp A., Widaa S., Langford C.,
RA   Yang F., Schuster S.C., Carter N.P., Harrow J., Ning Z., Herrero J.,
RA   Searle S.M., Enright A., Geisler R., Plasterk R.H., Lee C.,
RA   Westerfield M., de Jong P.J., Zon L.I., Postlethwait J.H.,
RA   Nusslein-Volhard C., Hubbard T.J., Roest Crollius H., Rogers J.,
RA   Stemple D.L.;
RT   "The zebrafish reference genome sequence and its relationship to the
RT   human genome.";
RL   Nature 496:498-503(2013).
RN   [2] {ECO:0000313|Ensembl:ENSDARP00000141982}
RP   IDENTIFICATION.
RC   STRAIN=Tuebingen {ECO:0000313|Ensembl:ENSDARP00000141982};
RG   Ensembl;
RL   Submitted (NOV-2015) to UniProtKB.
CC   -!- FUNCTION: Voltage-sensitive calcium channels (VSCC) mediate the
CC       entry of calcium ions into excitable cells and are also involved
CC       in a variety of calcium-dependent processes, including muscle
CC       contraction, hormone or neurotransmitter release, gene expression,
CC       cell motility, cell division and cell death. The isoform alpha-1B
CC       gives rise to N-type calcium currents. N-type calcium channels
CC       belong to the 'high-voltage activated' (HVA) group and are blocked
CC       by omega-conotoxin-GVIA (omega-CTx-GVIA) and by omega-agatoxin-
CC       IIIA (omega-Aga-IIIA). They are however insensitive to
CC       dihydropyridines (DHP), and omega-agatoxin-IVA (omega-Aga-IVA).
CC       Calcium channels containing alpha-1B subunit may play a role in
CC       directed migration of immature neurons.
CC       {ECO:0000256|RuleBase:RU003808}.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|RuleBase:RU003808};
CC       Multi-pass membrane protein {ECO:0000256|RuleBase:RU003808}.
CC   -!- SIMILARITY: Belongs to the calcium channel alpha-1 subunit
CC       (TC 1.A.1.11) family. {ECO:0000256|RuleBase:RU003808}.
CC   -!- CAUTION: The sequence shown here is derived from an Ensembl
CC       automatic analysis pipeline and should be considered as
CC       preliminary data. {ECO:0000313|Ensembl:ENSDARP00000141982}.
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DR   EMBL; AL929342; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BX571772; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   Ensembl; ENSDART00000172714; ENSDARP00000141982; ENSDARG00000021735.
DR   ZFIN; ZDB-GENE-060531-44; cacna1ba.
DR   GeneTree; ENSGT00830000128247; -.
DR   Reactome; R-DRE-112308; Presynaptic depolarization and calcium channel opening.
DR   Proteomes; UP000000437; Chromosome 5.
DR   ExpressionAtlas; A0A0R4IYM2; baseline.
DR   GO; GO:0005891; C:voltage-gated calcium channel complex; IEA:InterPro.
DR   GO; GO:0005245; F:voltage-gated calcium channel activity; IEA:InterPro.
DR   InterPro; IPR031649; GPHH_dom.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR014873; VDCC_a1su_IQ.
DR   InterPro; IPR005447; VDCC_N_a1su.
DR   InterPro; IPR002077; VDCCAlpha1.
DR   PANTHER; PTHR10037:SF161; PTHR10037:SF161; 2.
DR   Pfam; PF08763; Ca_chan_IQ; 1.
DR   Pfam; PF16905; GPHH; 1.
DR   Pfam; PF00520; Ion_trans; 4.
DR   PRINTS; PR00167; CACHANNEL.
DR   PRINTS; PR01631; NVDCCALPHA1.
DR   SMART; SM01062; Ca_chan_IQ; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|RuleBase:RU003808};
KW   Calcium channel {ECO:0000256|RuleBase:RU003808};
KW   Calcium transport {ECO:0000256|RuleBase:RU003808};
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000000437};
KW   Ion channel {ECO:0000256|RuleBase:RU003808};
KW   Ion transport {ECO:0000256|RuleBase:RU003808};
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000000437};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius};
KW   Transport {ECO:0000256|RuleBase:RU003808};
KW   Voltage-gated channel {ECO:0000256|RuleBase:RU003808}.
FT   TRANSMEM     12     29       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     50     70       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM     82    102       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    137    159       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    213    234       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    246    268       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    407    426       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    432    450       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    532    554       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM    610    632       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1093   1111       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1131   1151       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1163   1182       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1235   1257       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1347   1372       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1428   1446       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1458   1481       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1551   1569       Helical. {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM   1640   1663       Helical. {ECO:0000256|SAM:Phobius}.
FT   DOMAIN     1800   1834       Ca_chan_IQ. {ECO:0000259|SMART:SM01062}.
FT   COILED      628    655       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   2295 AA;  259576 MW;  D0A1D02A774D761D CRC64;
     MGSFLNAITP FEYMILATII ANCIVLGLEQ HLPALDKTPM SKRLDDTEPY FIGIFCFEAG
     IKIIALGFAF HKGSYLRNGW NVMDFVVVLT GILTIVGPDF DLRTLRAVRV LRPLKLVSGI
     PSLQVVLKSI MKAMVPLLQI GLLLFFAILM FAIIGLDFYM GKFHRTCFRT DTGEQVDEFP
     CGLESPAWTC ENGTECREYW IGPNFGITNF DNILFAVLTV FQCITMEGWV DILYNANDAS
     GNTWNWLYFI PLIIIGSFFM LNLVLGVLSG EFAKERERVE KRQEFLKLRR QQQIERELTG
     YLEWICKAEE VMLAEEDKNA EDKDDVAWYK RKCNNPVLKR AKKSKNDLIN AEEGEDHFTD
     ISSVAPQGSP FTRTSVKSSK IESLSYFRRK EKRFRFFIRR MVKAQSFYWT VLCIVGLNTL
     CVAIVHYDQP EWLTYALYLA EFVFLGLFLI EMSLKMYGLG PRTYFHSSFN CFDFGVIVGS
     IFEVIWAAVK PGASFGISVL RALRLLRIFK VTKYWNSLRN LVVSLLNSMK SIISLLFLLF
     LFIVVFALLG MQLFGGQFNF EDETPTTNFD TFPAAILTVF QILTGEDWNA VMYHGIESQG
     GVHRGMFCSV YFIVLTLFGN YTLLNVFLAI AVDNLANAQE LTKDEEEQEE AISKKLALQK
     AKEVKEVSPM SAANISITAF IRPNPGALSC SSSNSSSHSP SYVCSPAHHY LSKEQQRSLK
     MMSVWEQRTT QIRKHMLASS EALYQEELNP RLMSNLPLRT DIKTHLDRPL VVEPRCDGPI
     SPHSGWDKPQ DLQGEGSTPE ERVPPVFEPP QSHPPRKHHR HRERLSNETN ENGDTGHAKE
     GRHHVHHSRS KEHDGTRCKE GKGDRSRSRE GGRRHHHQSS VDEGVGGGER EHRHHHSHRH
     NREGNGVVSA GGKSERRSRQ KEGSRSGTRE GERCSRGENG GNGGRRRHRP RTSKAQSTLE
     GEEQHVNGEE EGKSQSHRHM DMGGDSMAVN PHQPSVGSRW CLEKPEDSDN KRNIGQTGGM
     STHIPVTVTS PPGETTLIPM NSIDSETVPM TEKNLEDLNQ SSIRPILPFS SMFIFNPTNP
     VRRLCHYIVS LRYFEMCILV VIAMSSIALA AEDPVQANAP RNNVLKYLDY VFTGVFTFEM
     VIKMVDLGLI LHPGSYFRDL WNILDFIVVS GALVAFAFSS FMGSHQSVNR GTKGKDISTI
     KSLRVLRVLR PLKTIKRLPK LKAVFDCVVN SLKNVLNILI VYILFMFIFA VIAVQLFKGK
     FFYCTDESKG LEKDCRGLFL DYDKDDVTAQ PREWKKYEFH YDNVLWAFLT LFTVSTGEGW
     PTVLKHSVDA TFEDQGPSPG YRIEMSIFYV VYFVVFPFFF VNIFVALIII TFQEQGDKVL
     SECSLEKNER ACIDFAINAK PLTRYMPQNQ QSFQYRLWKF VVSPPFEYSI MIMIALNTVV
     LMMKFHGAPD FYEAMLKYLN IVFTVLFSLE CILKIIAFGP LNYLKDAWNV FDFVTVLGSI
     TDILVTEINV KERQLNFSFL RLFRAARLIK LLRQGYTIRI LLWTFVQSFK ALPYVCLLIA
     MLFFIYAIIG MQVFGNIDLN DDTAINRHNN FRTFLQALML LFRSATGEAW HDIMLSCLSE
     RTCDPSSGTL GKECGSDFAY FYFVSFIFLC SFLMLNLFVA VIMDNFEYLT RDSSILGPHH
     LDEFIRVWAE YDPAACGRIK YLDMYEMLLH MSPPLGLGKK CPPRIAYKRL VKMNMPIADD
     NSVHFTSTLM ALIRTALEIK LASGMVAQRL SDAELKKELS TVWPNLSQKT MDLLVTPHKP
     NELTVGKVYA ALMIFDYYKQ NRAKRLQMQQ QQLKEQAGPG SQNKVSALLE PILPLTHMQD
     QPVNGVDSAS ECQAQTRPSS TTLNNGRTTL DNTIKGSSSW ASEKSKEVQK SKRRPMSRGQ
     SEDASNANTA QESVEMRKME NSANTVTSGG LEGQGRAASM PKLNAEMQRS HSRQSPGTLL
     EPIPDSPMRR SASTFAPQRP HEVNLNDYIL EKPVQERHHH HHHHHRCHHR RDRDKKQRSL
     DRSPTGHHKT TGTATDSVEE RAHDRGRSHE RKHHSSSGEK QRYYSCDRYA SREHCSSKSA
     VASCATSPSE TQEANLNKQG SGWAKGSPVL LTSGASTPSR GRRQLPQTPL TPRPSVAYRT
     ANSSPVQLLA TTTSLLPPSP GRLSRGLSEH NALLLSGSIS SSPAPVSRIN SEPFLGPPDH
     PAGLQPEAFA VFQENPSPQM GRSPQTVGMP FVAIPPPPPQ QFRRVPNGYH FSTGPSASRG
     RAQQYYPEAE VEDWC
//
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