ID A0A0R4J0S3_MOUSE Unreviewed; 396 AA.
AC A0A0R4J0S3;
DT 20-JAN-2016, integrated into UniProtKB/TrEMBL.
DT 20-JAN-2016, sequence version 1.
DT 27-MAR-2024, entry version 42.
DE SubName: Full=Reticulon 4 interacting protein 1 {ECO:0000313|Ensembl:ENSMUSP00000060940.6};
GN Name=Rtn4ip1 {ECO:0000313|Ensembl:ENSMUSP00000060940.6,
GN ECO:0000313|MGI:MGI:2178759};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090 {ECO:0000313|Ensembl:ENSMUSP00000060940.6, ECO:0000313|Proteomes:UP000000589};
RN [1] {ECO:0000313|Ensembl:ENSMUSP00000060940.6, ECO:0000313|Proteomes:UP000000589}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000060940.6,
RC ECO:0000313|Proteomes:UP000000589};
RX PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA Eichler E.E., Ponting C.P.;
RT "Lineage-specific biology revealed by a finished genome assembly of the
RT mouse.";
RL PLoS Biol. 7:E1000112-E1000112(2009).
RN [2] {ECO:0007829|PubMed:21183079}
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
RN [3] {ECO:0000313|Ensembl:ENSMUSP00000060940.6}
RP IDENTIFICATION.
RC STRAIN=C57BL/6J {ECO:0000313|Ensembl:ENSMUSP00000060940.6};
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the zinc-containing alcohol dehydrogenase
CC family. Quinone oxidoreductase subfamily.
CC {ECO:0000256|ARBA:ARBA00010371}.
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DR RefSeq; NP_570962.2; NM_130892.4.
DR AlphaFoldDB; A0A0R4J0S3; -.
DR SMR; A0A0R4J0S3; -.
DR EPD; A0A0R4J0S3; -.
DR jPOST; A0A0R4J0S3; -.
DR ProteomicsDB; 344803; -.
DR Antibodypedia; 32150; 286 antibodies from 24 providers.
DR DNASU; 170728; -.
DR Ensembl; ENSMUST00000054418.12; ENSMUSP00000060940.6; ENSMUSG00000019864.15.
DR GeneID; 170728; -.
DR KEGG; mmu:170728; -.
DR AGR; MGI:2178759; -.
DR CTD; 84816; -.
DR MGI; MGI:2178759; Rtn4ip1.
DR VEuPathDB; HostDB:ENSMUSG00000019864; -.
DR GeneTree; ENSGT00880000138028; -.
DR OMA; MKAWAYD; -.
DR OrthoDB; 2321660at2759; -.
DR PhylomeDB; A0A0R4J0S3; -.
DR BioGRID-ORCS; 170728; 17 hits in 78 CRISPR screens.
DR Proteomes; UP000000589; Chromosome 10.
DR Bgee; ENSMUSG00000019864; Expressed in interventricular septum and 204 other cell types or tissues.
DR ExpressionAtlas; A0A0R4J0S3; baseline and differential.
DR GO; GO:0005741; C:mitochondrial outer membrane; IEA:Ensembl.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd08248; RTN4I1; 1.
DR Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR013154; ADH-like_N.
DR InterPro; IPR011032; GroES-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR020843; PKS_ER.
DR InterPro; IPR002364; Quin_OxRdtase/zeta-crystal_CS.
DR InterPro; IPR037397; RTN4I1.
DR PANTHER; PTHR11695; ALCOHOL DEHYDROGENASE RELATED; 1.
DR PANTHER; PTHR11695:SF294; RETICULON-4-INTERACTING PROTEIN 1, MITOCHONDRIAL; 1.
DR Pfam; PF08240; ADH_N; 1.
DR Pfam; PF13602; ADH_zinc_N_2; 1.
DR SMART; SM00829; PKS_ER; 1.
DR SUPFAM; SSF50129; GroES-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR PROSITE; PS01162; QOR_ZETA_CRYSTAL; 1.
PE 1: Evidence at protein level;
KW Proteomics identification {ECO:0007829|EPD:A0A0R4J0S3,
KW ECO:0007829|MaxQB:A0A0R4J0S3};
KW Reference proteome {ECO:0000313|Proteomes:UP000000589}.
FT DOMAIN 52..393
FT /note="Enoyl reductase (ER)"
FT /evidence="ECO:0000259|SMART:SM00829"
SQ SEQUENCE 396 AA; 43399 MW; B1EB2B78582ECA7F CRC64;
MGVLKTCVLR RSACAAACFW RRTVIPKPPF RGISTTSARS TVMPAWVIDK YGKNEVLRFT
QNMMLPIIHY PNEVIIKVHA ASVNPIDVNM RSGYGATALN MKRDPLHMKT KGEEFPLTLG
RDVSGVVMEC GLDVKYFQPG DEVWAAVPPW KQGTLSEFVV VSGNEVSHKP KSLTHTQAAS
LPYVALTAWS AINKVGGLSD RNCKGKRALI LGASGGVGTF AIQVMKAWGA HVTAVCSKDA
SELVRKLGAD EVIDYTLGSV EEQLKSLKLF DFILDNVGGS TETWALNFLK KWSGATYVTL
VTPFLLNMDR LGVADGMLQT GVTVGTKALK HLWQGVHYRW AFFMASGPYL DEIAELVDAG
KIRPVIERTF PFSEVPEAFL KVERGHARGK TVVNVV
//
