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Database: UniProt
Entry: A0A0S2DHB6_LYSEN
LinkDB: A0A0S2DHB6_LYSEN
Original site: A0A0S2DHB6_LYSEN 
ID   A0A0S2DHB6_LYSEN        Unreviewed;      3563 AA.
AC   A0A0S2DHB6;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   24-JAN-2024, entry version 40.
DE   SubName: Full=Beta-ketoacyl synthase/short chain dehydrogenase/methyltransferase domain {ECO:0000313|EMBL:ALN57844.1};
GN   ORFNames=GLE_2495 {ECO:0000313|EMBL:ALN57844.1};
OS   Lysobacter enzymogenes.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Xanthomonadales;
OC   Xanthomonadaceae; Lysobacter.
OX   NCBI_TaxID=69 {ECO:0000313|EMBL:ALN57844.1, ECO:0000313|Proteomes:UP000061569};
RN   [1] {ECO:0000313|EMBL:ALN57844.1, ECO:0000313|Proteomes:UP000061569}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C3 {ECO:0000313|EMBL:ALN57844.1,
RC   ECO:0000313|Proteomes:UP000061569};
RA   Kobayashi D.Y.;
RT   "Genome sequences of Lysobacter enzymogenes strain C3 and Lysobacter
RT   antibioticus ATCC 29479.";
RL   Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC   -!- PATHWAY: Lipid metabolism; fatty acid biosynthesis.
CC       {ECO:0000256|ARBA:ARBA00005194}.
CC   -!- SIMILARITY: Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP
CC       synthases family. {ECO:0000256|ARBA:ARBA00008467}.
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DR   EMBL; CP013140; ALN57844.1; -; Genomic_DNA.
DR   STRING; 69.GLE_2495; -.
DR   KEGG; lez:GLE_2495; -.
DR   PATRIC; fig|69.6.peg.2458; -.
DR   OMA; ESMVACE; -.
DR   OrthoDB; 9030879at2; -.
DR   UniPathway; UPA00094; -.
DR   Proteomes; UP000061569; Chromosome.
DR   GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR   GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR   GO; GO:0008757; F:S-adenosylmethionine-dependent methyltransferase activity; IEA:InterPro.
DR   GO; GO:0006633; P:fatty acid biosynthetic process; IEA:UniProtKB-UniPathway.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   CDD; cd08953; KR_2_SDR_x; 1.
DR   CDD; cd00833; PKS; 2.
DR   Gene3D; 1.10.1240.100; -; 2.
DR   Gene3D; 3.40.47.10; -; 2.
DR   Gene3D; 1.10.1200.10; ACP-like; 4.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR   Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR036736; ACP-like_sf.
DR   InterPro; IPR018201; Ketoacyl_synth_AS.
DR   InterPro; IPR014031; Ketoacyl_synth_C.
DR   InterPro; IPR014030; Ketoacyl_synth_N.
DR   InterPro; IPR013217; Methyltransf_12.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR032821; PKS_assoc.
DR   InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR   InterPro; IPR042104; PKS_dehydratase_sf.
DR   InterPro; IPR020807; PKS_DH.
DR   InterPro; IPR013968; PKS_KR.
DR   InterPro; IPR020806; PKS_PP-bd.
DR   InterPro; IPR009081; PP-bd_ACP.
DR   InterPro; IPR006162; Ppantetheine_attach_site.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   InterPro; IPR016039; Thiolase-like.
DR   PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR   PANTHER; PTHR43775:SF37; FATTY ACID SYNTHASE; 1.
DR   Pfam; PF16197; KAsynt_C_assoc; 2.
DR   Pfam; PF00109; ketoacyl-synt; 2.
DR   Pfam; PF02801; Ketoacyl-synt_C; 2.
DR   Pfam; PF08659; KR; 2.
DR   Pfam; PF08242; Methyltransf_12; 1.
DR   Pfam; PF21089; PKS_DH_N; 1.
DR   Pfam; PF00550; PP-binding; 4.
DR   Pfam; PF14765; PS-DH; 1.
DR   SMART; SM00826; PKS_DH; 1.
DR   SMART; SM00822; PKS_KR; 2.
DR   SMART; SM00825; PKS_KS; 2.
DR   SMART; SM00823; PKS_PP; 4.
DR   SMART; SM01294; PKS_PP_betabranch; 4.
DR   SUPFAM; SSF47336; ACP-like; 4.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 4.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   SUPFAM; SSF53901; Thiolase-like; 2.
DR   PROSITE; PS50075; CARRIER; 4.
DR   PROSITE; PS00606; KS3_1; 1.
DR   PROSITE; PS52004; KS3_2; 2.
DR   PROSITE; PS00012; PHOSPHOPANTETHEINE; 3.
PE   3: Inferred from homology;
KW   Fatty acid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW   Fatty acid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW   Lipid biosynthesis {ECO:0000256|ARBA:ARBA00023160};
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023160};
KW   Methyltransferase {ECO:0000313|EMBL:ALN57844.1};
KW   Multifunctional enzyme {ECO:0000256|ARBA:ARBA00023268};
KW   Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000061569};
KW   Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000313|EMBL:ALN57844.1}.
FT   DOMAIN          58..481
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          1181..1258
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          1320..1738
FT                   /note="Ketosynthase family 3 (KS3)"
FT                   /evidence="ECO:0000259|PROSITE:PS52004"
FT   DOMAIN          3187..3265
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3327..3401
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   DOMAIN          3454..3531
FT                   /note="Carrier"
FT                   /evidence="ECO:0000259|PROSITE:PS50075"
FT   REGION          1..58
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          648..668
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1135..1154
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1274..1318
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          2250..2305
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3293..3314
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3406..3459
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          3533..3563
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        3406..3430
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   3563 AA;  376763 MW;  A7A1104909B1981C CRC64;
     MDSMNRQDVL RDLQSRRITP EQAKRLLAEA AAQPAPAAPS AAAASTARTG ASPSPGADER
     IAIVGMSGRY PGADSLDAFW ELLSQGRSGV RTVPASRWDV ERFYDPRPQQ PGKVYCKWLG
     ALDDVECFDP LFFGISPAEA TVMDPQHRVF LQEGYRAFED AGYAPAALDG ARCGVYLGIM
     GNEYVGLCRQ AGAGIGEATG NSSSIAAARI AYHLNLKGPA IAVDTACSSS LVATHLACQA
     LLAGEIDLAL AGGVTLYLSP ETHVSMCAAG MLSASGRCSA FDDSADGFVP GEGVGTLVLK
     RLSDAIAAGD RIHAVVLGSG INQDGRTNGI TAPSAKSQAD LLREVYRRHR IDPASISYVE
     AHGTGTRLGD PIEFEALSTV FGEATADLHF CALGSVKSNI GHASAAAGVA GVHKTLLSLR
     EKRLVPTLHY SRPNPHVELR GSPFVINTEL REWRVPEASA RRAAVSSFGY SGTNAHLVLE
     EWNPAEAHAA PQADAREPQL LLLSARGADE LRAQAQALAR WLQRDAATPL ADVAYTLQVG
     RAAFEQRLAF VAADRAEALA RLEDFLAGRA APASFAGRVT AQMRESHRAD SAARAPLRAD
     ALALAGLGER WVGGFDPDWR DLPRSRPGRF AHLPTYAFAK ERCWVTTGDG ASESGPRSEP
     VMQPPAPPVE APVHRVPEAL AALELLIGDT EPVEAPVPQA LDAQARVAIV GASAQAMAQF
     ARVWPRATAL APPAADAIGA WADALRALGR IDRLVWFAGD GGGERVDELL DYAARSAPVL
     ACFHAIKALL DQGYGDGALE WTLVTRDAGT DPSHAALQGL VASAVKENAQ WSLRLVDLGR
     EDAIGAAAGI GVEQLLAVPA DTQGRGWLCH DGQWARERLR PVPVPARTDG AFRRDGVYLI
     VGGAGGVGEV FSEYLLRHYQ ARVVWVGRRA ADADIEAKRA RLAALGPAPL YLQADAADPA
     ALAAVRAQAL RAYGRIDCVV HSAIELHDQG LAVMDAARFE RAFATKAKIA ANLLGAFADD
     AADGVVLFSS LVSYSRDAGQ SNYSAGSLYQ DALARGLASR YGRRVKTLNW GFWGDIGATA
     SLPPRVRERF AQAGIGALRP VEAMAALEVF MHAALPQLAA LHRLGAQGLR VPAPEPAADA
     AAAQPPAPQA ERAPPIERDA ELAASEPRPD YEPDQTVAAI DLEAHVKHTL LAQLAAILKL
     APERIDPDSA FAGYGVDSIS SVRIVRALND ALGIELAGTS LFDHSSVNKL VRHVLQDHDT
     AQLQAAVRAA LPQPVAAPAA SAQPATDTDR RATPAANDAS ADSDARAQPA AQRSGAAAAP
     GPIAIVGMSG RFPQSPDLQT LWAHLAAGDE VTEPITRWRI DSLGLPDDIK VCPRGGFLGD
     IDQFDPLFFN ISGTEANFMD PQHRVLLETS WHALEDAGYA GQGIAGARCG VYMGFNGGDY
     GELLHGQPSL PPHAMWGNAA SVLSARIAYY LDLQGPAITL DTACSSSLVA VHLACQGLWT
     GETDVALAGG VWIQCTPGFL ISSSRAGMLS PTGRCRAFGD QADGFVPSEG VGVVVLKRLQ
     DALDAGDHIY GVIRGSAINQ DGASNGITAP SAGAQERLQR HVYDSFGIDA GRLQMVEAHG
     TGTILGDPIE AAALSRSLSH YSDRTGFCAI GSIKTNIGHT GAAAGVAGLI KVLLSLQHRQ
     IPPSLHFDRP NPHIAFADSP LTVNTQLKHW EAPAAGRRLA AVSSFGLSGT NAHVVVEEAP
     PAAAAASAAQ PTLLVLSGFR EEDLPAQVAA LAEHLERESA LELSAAGYTL AVGRRHHRHR
     LALVAHDAAD AAAELRRWLA GGSSRVLAGT ATAGNGGDER FAPARQRLHA LVQARDDGER
     ARLLAELAAL HVQGLAPELG SAFASQRRVA LPLYRFSRKR HWVPERAQPR VEAAAAPVAA
     VVAPAAVEPA AVVPATVAPA ASAAPATAAP PSAVSPAPKP AAANVAGVVA TAAPLHPFVH
     AAIAGADGPR YATRWSGQEP FLRDHVVQGA PMLPGAACLE MARAAAELAR PGQRARQLRN
     VVWLRPLAVA EPVDLQVALE PVPARDNELA FRILGAGSDT PHCQGRVVLD AAPGRGSFVD
     VGTLRMRCDL RTLKGGDYYR VFDLMGLAYG ESYRGIERAF VGENQLLAQI RLPAAAVQDG
     FHLHPSLLDS ALQASIGFEI GDGREERPSD GAAPRSLMLF ALDQIELYGP CTEQMWVWIR
     RDPRGNGNKL DIDLCEPTGR VVAALRGVTS REAGAPQRPA AAASASAATR PAQAAPPQPA
     PSAPAPVAAP ASAGAHGEAF PGGDRVGALT LAPAWEPAAP PQAEAWPQEK ANVVVIGGDE
     TQFAQLRKRH PRARHLPAAI ADTADRAAEE LRGAGNIEHL FWLAPPSQAR AVDSESIVVD
     QQRGVMATFR LVKALLKLGY AGKPLGLTVV TVGSQPVADG EPLDPTHAGV HGLIGTLAKE
     YPDWRVRLVD VQAGQPWPLD ALLALPADRD GNAWAHRHGR WHRQRWIQCA LPEPEQTAFR
     RNGVYVVVGG AGGIGEAFSE YLIRRYAAQV VWIGLRKRDE IVEEKIGRLS QLGPAPHYVS
     ADATDQPSLE RACADIERRF GTVHGVVHAA LLMAGDPLER MDEQRFWRGL AAKIEVSVRM
     AQAFAHLPLD FVLFFSSIQA LEKTPRQANY AAGCTVEDAY AALLAQQWRC PVRVVNWGYW
     GSVGFAAISS GYRNWIAQAG MGSVEPAEGM AALERLLAGP LRQFAFLKTR REDALTGVQF
     SDDRLWRVGA TAPVVPLDAP VDLDPAGLAG QGLPARFEGL LLELLRHELD ALGVFAAATA
     QAREALIAPQ YRAWLRHTLD LLAEHGLAVR RGEAWHAAGP ASASSPWQEW ERNAPQWLDS
     AELAAPVRLA EATLRELGPV LTGQRAATDV LFPKSSPHLV EGIYRDSPVP DYFNKVLCSA
     VVRYIERRRR IDPDVRLRIL EIGAGTGGTT APLVRALEPY AACVAEYRFT DISRSFALAA
     QDEYAQRAPY MSYGSFDVER AAAAQGIDVG GFDIVVAANV LHATGDIART LRNAKAALKR
     NGLLVLNEVC ATSLFAHVTF GLLKGWWLYE DAHLRIPGSP ALSPESWRAV LAEQGFGAIG
     LPAEGARSLG QQIVLASSDG WIRQPVGAQV VAVQAGEASR APEPVVAAQA RPVAESAPVA
     PAAPAAEDEE AAIRRIVRDA LIATLDVPAH ELRDDAPLTD YGLDSMLAVQ TVEVLNTTAG
     TELTTTSLFD HPSIDAVVDH LLSLRPRNAS VAASVANEPA NAVASRAAPP AVAPVAAPQP
     QPQPQPQPAV QAPSLMPAPV APAAASAGIA QAIAQALVEI AGIDSGDIRG DAEFVDYGID
     SMLAVQIVEA LNRRLVVELT TTSLFDYPTI DALVAHLLAS ASHGAVAAQP SQPSQPSQPQ
     ASQSWTPSAP QSQPAPQPQL APQAAVAAPA PQPARSGGLR ERVRQELLAV LAIDAADFDP
     ATPFTDYGMD SMLAVQWVER LNQSLRLELT TTTPFDHPTL DALMQHIGEE HAEDAAAATG
     ESVAPTPQTA PAKRREQPMS YTI
//
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