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Database: UniProt
Entry: A0A0S2EIE9_9RHIZ
LinkDB: A0A0S2EIE9_9RHIZ
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ID   A0A0S2EIE9_9RHIZ        Unreviewed;       525 AA.
AC   A0A0S2EIE9;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   05-JUL-2017, entry version 13.
DE   RecName: Full=Chromosomal replication initiator protein DnaA {ECO:0000256|HAMAP-Rule:MF_00377, ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724181};
GN   Name=dnaA {ECO:0000256|HAMAP-Rule:MF_00377};
GN   ORFNames=M673_00010 {ECO:0000313|EMBL:ALN71069.1};
OS   Aureimonas sp. AU20.
OC   Bacteria; Proteobacteria; Alphaproteobacteria; Rhizobiales;
OC   Aurantimonadaceae; Aureimonas.
OX   NCBI_TaxID=1349819 {ECO:0000313|EMBL:ALN71069.1, ECO:0000313|Proteomes:UP000060544};
RN   [1] {ECO:0000313|EMBL:ALN71069.1, ECO:0000313|Proteomes:UP000060544}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AU20 {ECO:0000313|EMBL:ALN71069.1,
RC   ECO:0000313|Proteomes:UP000060544};
RX   PubMed=26534993; DOI=10.1073/pnas.1514326112;
RA   Anda M., Ohtsubo Y., Okubo T., Sugawara M., Nagata Y., Tsuda M.,
RA   Minamisawa K., Mitsui H.;
RT   "Bacterial clade with the ribosomal RNA operon on a small plasmid
RT   rather than the chromosome.";
RL   Proc. Natl. Acad. Sci. U.S.A. 112:14343-14347(2015).
CC   -!- FUNCTION: Plays an important role in the initiation and regulation
CC       of chromosomal replication. Binds to the origin of replication; it
CC       binds specifically double-stranded DNA at a 9 bp consensus (dnaA
CC       box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic
CC       phospholipids. {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00724167}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
CC       ECO:0000256|SAAS:SAAS00756131}.
CC   -!- SIMILARITY: Belongs to the DnaA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00377, ECO:0000256|RuleBase:RU004227,
CC       ECO:0000256|SAAS:SAAS00555179}.
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DR   EMBL; CP006367; ALN71069.1; -; Genomic_DNA.
DR   EnsemblBacteria; ALN71069; ALN71069; M673_00010.
DR   KEGG; aua:M673_00010; -.
DR   PATRIC; fig|1349819.3.peg.2; -.
DR   KO; K02313; -.
DR   Proteomes; UP000060544; Chromosome.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0003688; F:DNA replication origin binding; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006270; P:DNA replication initiation; IEA:UniProtKB-HAMAP.
DR   GO; GO:0006275; P:regulation of DNA replication; IEA:UniProtKB-HAMAP.
DR   CDD; cd06571; Bac_DnaA_C; 1.
DR   Gene3D; 1.10.1750.10; -; 1.
DR   HAMAP; MF_00377; DnaA_bact; 1.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR001957; Chromosome_initiator_DnaA.
DR   InterPro; IPR020591; Chromosome_initiator_DnaA-like.
DR   InterPro; IPR018312; Chromosome_initiator_DnaA_CS.
DR   InterPro; IPR013317; DnaA.
DR   InterPro; IPR013159; DnaA_C.
DR   InterPro; IPR024633; DnaA_N_dom.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR010921; Trp_repressor/repl_initiator.
DR   PANTHER; PTHR30050:SF12; PTHR30050:SF12; 1.
DR   Pfam; PF00308; Bac_DnaA; 1.
DR   Pfam; PF08299; Bac_DnaA_C; 1.
DR   Pfam; PF11638; DnaA_N; 1.
DR   PRINTS; PR00051; DNAA.
DR   SMART; SM00382; AAA; 1.
DR   SMART; SM00760; Bac_DnaA_C; 1.
DR   SUPFAM; SSF48295; SSF48295; 1.
DR   SUPFAM; SSF52540; SSF52540; 1.
DR   TIGRFAMs; TIGR00362; DnaA; 1.
DR   PROSITE; PS01008; DNAA; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731922};
KW   Complete proteome {ECO:0000313|Proteomes:UP000060544};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|SAAS:SAAS00756112};
KW   DNA replication {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU004227, ECO:0000256|SAAS:SAAS00731887};
KW   DNA-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00756124};
KW   Nucleotide-binding {ECO:0000256|HAMAP-Rule:MF_00377,
KW   ECO:0000256|RuleBase:RU000577, ECO:0000256|SAAS:SAAS00731897}.
FT   DOMAIN      218    346       AAA. {ECO:0000259|SMART:SM00382}.
FT   DOMAIN      433    502       Bac_DnaA_C. {ECO:0000259|SMART:SM00760}.
FT   NP_BIND     226    233       ATP. {ECO:0000256|HAMAP-Rule:MF_00377}.
SQ   SEQUENCE   525 AA;  57874 MW;  3A6E518F5ABBA6F2 CRC64;
     MTGLLPATPP KAPRAPVRAG APRTAPSALT AARIQPQEPV MSPAHGDAEI LDRVNARLKA
     HLGPDVFASW FTRMKLVNAG KGVVQLSVPT AFLRTWINGH YKDLLLQIFS EEIPGTLKVD
     IAVRSAVRGP AAPAAPAQIA RPRDGALPAP VAQSLPATAA PRANTERAQA GEMPRQQSDF
     GSPLDPRYIF ESFVEGASNR VALAAARSIA ENGPQSVRFN PLFLHATVGL GKTHLLQAIA
     NAALEREDRP RVVYLTAEYF MWRFATAIRD NQALDFKENL RGIDILIIDD MQFLQGKSIQ
     QEFCHLLNAL IDSARQVIVA ADRPAFELES LDSRVRSRLA GGVAIEMVSP DFEMRRGILS
     ARVEAMRAAD PSFAINEGVL DTIARRVTGS GRDLEGAFNQ IAFRHSVGQP LSSQHLDDLL
     NQLTRAGAEK RVRIEDILKF VSRHYNISRT DILSARRTRT IVRPRQIAMY LAKTMTPRSL
     PEIGRRFGGR DHTTVLHAVR KIEAERAIDQ KLAEELDVIR RMIEE
//
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