ID A0A0S2I3P5_9BACT Unreviewed; 1073 AA.
AC A0A0S2I3P5;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE RecName: Full=site-specific DNA-methyltransferase (adenine-specific) {ECO:0000256|ARBA:ARBA00011900};
DE EC=2.1.1.72 {ECO:0000256|ARBA:ARBA00011900};
GN ORFNames=L21SP5_03166 {ECO:0000313|EMBL:ALO16781.1};
OS Salinivirga cyanobacteriivorans.
OC Bacteria; Bacteroidota; Bacteroidia; Bacteroidales; Salinivirgaceae;
OC Salinivirga.
OX NCBI_TaxID=1307839 {ECO:0000313|EMBL:ALO16781.1, ECO:0000313|Proteomes:UP000064893};
RN [1] {ECO:0000313|EMBL:ALO16781.1, ECO:0000313|Proteomes:UP000064893}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=L21-Spi-D4 {ECO:0000313|EMBL:ALO16781.1,
RC ECO:0000313|Proteomes:UP000064893};
RA Spring S., Bunk B., Sproer C., Klenk H.-P.;
RT "Description and complete genome sequence of a novel strain predominating
RT in hypersaline microbial mats and representing a new family of the
RT Bacteriodetes phylum.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an
CC N(6)-methyl-2'-deoxyadenosine in DNA + H(+) + S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:15197, Rhea:RHEA-COMP:12418, Rhea:RHEA-
CC COMP:12419, ChEBI:CHEBI:15378, ChEBI:CHEBI:57856, ChEBI:CHEBI:59789,
CC ChEBI:CHEBI:90615, ChEBI:CHEBI:90616; EC=2.1.1.72;
CC Evidence={ECO:0000256|ARBA:ARBA00001279};
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DR EMBL; CP013118; ALO16781.1; -; Genomic_DNA.
DR RefSeq; WP_057954132.1; NZ_CP013118.1.
DR AlphaFoldDB; A0A0S2I3P5; -.
DR REBASE; 131154; BspD4ORF3166P.
DR KEGG; blq:L21SP5_03166; -.
DR PATRIC; fig|1307839.3.peg.3328; -.
DR OrthoDB; 9759819at2; -.
DR Proteomes; UP000064893; Chromosome.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0008170; F:N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0006306; P:DNA methylation; IEA:InterPro.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR InterPro; IPR003356; DNA_methylase_A-5.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR InterPro; IPR041635; Type_ISP_LLaBIII_C.
DR PANTHER; PTHR33841; DNA METHYLTRANSFERASE YEEA-RELATED; 1.
DR PANTHER; PTHR33841:SF5; TYPE II METHYLTRANSFERASE M.HINDII; 1.
DR Pfam; PF02384; N6_Mtase; 1.
DR Pfam; PF18135; Type_ISP_C; 1.
DR PRINTS; PR00507; N12N6MTFRASE.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000313|EMBL:ALO16781.1};
KW Helicase {ECO:0000313|EMBL:ALO16781.1};
KW Hydrolase {ECO:0000313|EMBL:ALO16781.1};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603};
KW Nucleotide-binding {ECO:0000313|EMBL:ALO16781.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000064893};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 295..509
FT /note="DNA methylase adenine-specific"
FT /evidence="ECO:0000259|Pfam:PF02384"
FT DOMAIN 693..1065
FT /note="Type ISP restriction-modification enzyme LLaBIII C-
FT terminal specificity"
FT /evidence="ECO:0000259|Pfam:PF18135"
SQ SEQUENCE 1073 AA; 124358 MW; 6E05FF06EFD68E54 CRC64;
MIQTYLNKIN TRFKNGISKE HSYRGDLETL IRELVPGIEI TNEPANVTDC GNPDYVITKG
KIPIGYIEAK DIGKDLNNKG YKEQFDRYRN ALENLIITDY TWFQFFQNGE LVHEIRIGEI
ENNQIKPLNG NFAQFTNLIQ NFATFIGQTI KSPKKLAEMM AAKAKLLQNI LENAVTSDEE
TQENTSLQGQ YKTFQNILIH DLTPKGFADI YAQTLAYGMF AARLHDTTLE DFSRQEAAEL
IPKSNPFLRK LFGYVAGPDI DERIKRTVDN LADVFRATNI RELLKNFGKT TQTHDPIIHF
YETFLAEYDP KLRKTRGVWY TPEPVVNFIV CAVDDILKTE FNLPDGLADT TKTKIKVPVA
GSKKPMEKEV HKVQILDPAT GTGTFLAEVV KFIYNKKFKA MQGAWSSYVD EHLIPRLNGF
ELLMASYSMA HLKLDMLLQE TGYNPTKTQR FNIYLTNSLE EHHPDTGTLF SNWLSTEANE
ANHIKRDTPV MCVIGNPPYS GESSNKGEWI MNLMEDYKRE PGGKEKLKER NPKWINDDYV
KFLRYGQYYI EKNGSGVLAY INPHGFLDNP TFRGMRWNLL KTYDKIYTID LHGNSKKKET
APDGSLDFNV FDIQQGVSIN IFVKTGKKQV NKLANVLHYD LYGKRDFKYD FLNKKSIQSI
DFNELTNVAP MYFMVQKDFE AQKTYDEGFL VSKLFSLSNV GIVTSRDEFT IHQSKEEVKS
TIDEFLSLED EDARKKFNLG KDVRDWKVSY AKADLNKYYP DKGSFTKISY RPFDDKWTFF
TGKSKGFHCY PRKEVMQHFL KDENIGLVVA RQCASDWRYI FISKLIGEFN LTGTAGRYGS
GNYFPLYLYP DTQNDGMYAI EKLSKKGSKP NLNMKIVVQI EEKLGLDFES EKSANKNKFA
PIDLLDYIYA VLHSPSYRKK YKEFLKTDFP RIPYPKYKET FWNLVELGKQ IREIHLLESS
KVEEYITSYP KDGDNTITRK IAQKDWEITD TKKQLGRIWI NDEQYFENIP LVAWEFYIGG
YQPAQKWLKD RAPKKGEPGR TLSYEDILHY QKIIVALTET DWLMQEVDKI EFE
//
