ID A0A0S2JGD6_9GAMM Unreviewed; 349 AA.
AC A0A0S2JGD6;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase {ECO:0000313|EMBL:ALO35055.1};
DE EC=2.1.1.14 {ECO:0000313|EMBL:ALO35055.1};
GN ORFNames=CMT41_10260 {ECO:0000313|EMBL:ALO35055.1};
OS Colwellia sp. MT41.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Alteromonadales;
OC Colwelliaceae; Colwellia.
OX NCBI_TaxID=58049 {ECO:0000313|EMBL:ALO35055.1, ECO:0000313|Proteomes:UP000065319};
RN [1] {ECO:0000313|EMBL:ALO35055.1, ECO:0000313|Proteomes:UP000065319}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MT41 {ECO:0000313|EMBL:ALO35055.1,
RC ECO:0000313|Proteomes:UP000065319};
RA Kyaw T.S., Ugalde J., Peoples L., Narasingarao P., Chastain R.A.,
RA Yayanos A., Methe B.A., Bartlett D.H.;
RT "Distinctive Gene and Protein Characteristics of Extremely Piezophilic
RT Colwellia.";
RL Submitted (NOV-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC Evidence={ECO:0000256|ARBA:ARBA00001947};
CC -!- SIMILARITY: Belongs to the vitamin-B12 independent methionine synthase
CC family. {ECO:0000256|ARBA:ARBA00009553}.
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DR EMBL; CP013145; ALO35055.1; -; Genomic_DNA.
DR RefSeq; WP_058027185.1; NZ_CP013145.1.
DR AlphaFoldDB; A0A0S2JGD6; -.
DR STRING; 58049.CMT41_10260; -.
DR KEGG; com:CMT41_10260; -.
DR OrthoDB; 244285at2; -.
DR Proteomes; UP000065319; Chromosome.
DR GO; GO:0003871; F:5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0009086; P:methionine biosynthetic process; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR CDD; cd03311; CIMS_C_terminal_like; 1.
DR Gene3D; 3.20.20.210; -; 1.
DR InterPro; IPR002629; Met_Synth_C/arc.
DR InterPro; IPR016456; Met_Synthase_cat.
DR InterPro; IPR038071; UROD/MetE-like_sf.
DR PANTHER; PTHR30519; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR PANTHER; PTHR30519:SF0; 5-METHYLTETRAHYDROPTEROYLTRIGLUTAMATE--HOMOCYSTEINE METHYLTRANSFERASE; 1.
DR Pfam; PF01717; Meth_synt_2; 1.
DR PIRSF; PIRSF005632; Met_synth_catalytic_prd; 1.
DR SUPFAM; SSF51726; UROD/MetE-like; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Methyltransferase {ECO:0000313|EMBL:ALO35055.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000065319};
KW Transferase {ECO:0000313|EMBL:ALO35055.1};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 10..334
FT /note="Cobalamin-independent methionine synthase MetE C-
FT terminal/archaeal"
FT /evidence="ECO:0000259|Pfam:PF01717"
SQ SEQUENCE 349 AA; 39201 MW; 8E1ACA34B3D5FC6A CRC64;
MKTNILKALL PTSTAGSLPK PAWLAQPETL WSPWKLQGDE LIAGKHDALR LSLQDQQQAG
LDIVSDGEQT RQHFVTTFLE HLNGVDFEQR KTVKIRDRYE ASVPTVVGPV SRQKPVFVDD
AKFLRQQTKQ TIKWALPGPM TMVDTLYDDH YKSREKLAWE FAKILNQEAK ELEAAGVDII
QFDEPAFNVF FDEVNDWGIA CLERAIEGLK CETAVHICYG YGIKANTDWK NTLGSEWRQY
EQAFPKLQKS NIDIISLECH NSRVPMELLE LIRGKKVMVG AIDVASNTIE TPEEVAKTLR
EALKYVDADK LYPSTNCGMA PLSQQVARGK LNALTAGAAI VRRELATSN
//
