ID A0A0S2W678_9FIRM Unreviewed; 254 AA.
AC A0A0S2W678;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 37.
DE SubName: Full=IclR family transcriptional regulator {ECO:0000313|EMBL:PVY48610.1};
DE SubName: Full=Transcriptional regulator, IclR family {ECO:0000313|EMBL:ALP94835.1};
GN ORFNames=C7373_106117 {ECO:0000313|EMBL:PVY48610.1}, IB211_02444c
GN {ECO:0000313|EMBL:ALP94835.1};
OS Intestinimonas butyriciproducens.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Intestinimonas.
OX NCBI_TaxID=1297617 {ECO:0000313|EMBL:ALP94835.1, ECO:0000313|Proteomes:UP000064844};
RN [1] {ECO:0000313|EMBL:ALP94835.1, ECO:0000313|Proteomes:UP000064844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF211 {ECO:0000313|EMBL:ALP94835.1,
RC ECO:0000313|Proteomes:UP000064844};
RX PubMed=26620920; DOI=10.1038/ncomms10062;
RA Bui T.P., Ritari J., Boeren S., de Waard P., Plugge C.M., de Vos W.M.;
RT "Production of butyrate from lysine and the Amadori product fructoselysine
RT by a human gut commensal.";
RL Nat. Commun. 6:10062-10062(2015).
RN [2] {ECO:0000313|Proteomes:UP000064844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF211 {ECO:0000313|Proteomes:UP000064844};
RA de Vos W.M., Bui N.T.P., Plugge C.M., Ritari J.;
RT "A butyrogenic pathway from the amino acid lysine in a human gut
RT commensal.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:PVY48610.1, ECO:0000313|Proteomes:UP000245778}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 26588 {ECO:0000313|EMBL:PVY48610.1,
RC ECO:0000313|Proteomes:UP000245778};
RA Goeker M.;
RT "Genomic Encyclopedia of Type Strains, Phase IV (KMG-IV): sequencing the
RT most valuable type-strain genomes for metagenomic binning, comparative
RT biology and taxonomic classification.";
RL Submitted (APR-2018) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; CP011307; ALP94835.1; -; Genomic_DNA.
DR EMBL; QEKK01000006; PVY48610.1; -; Genomic_DNA.
DR RefSeq; WP_033118343.1; NZ_QEKK01000006.1.
DR AlphaFoldDB; A0A0S2W678; -.
DR STRING; 1297617.IB211_02444c; -.
DR GeneID; 60291846; -.
DR KEGG; ibu:IB211_02444c; -.
DR eggNOG; COG1414; Bacteria.
DR OrthoDB; 9791752at2; -.
DR Proteomes; UP000064844; Chromosome.
DR Proteomes; UP000245778; Unassembled WGS sequence.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR Gene3D; 3.30.450.40; -; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR029016; GAF-like_dom_sf.
DR InterPro; IPR014757; Tscrpt_reg_IclR_C.
DR InterPro; IPR005471; Tscrpt_reg_IclR_N.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR30136; HELIX-TURN-HELIX TRANSCRIPTIONAL REGULATOR, ICLR FAMILY; 1.
DR PANTHER; PTHR30136:SF24; HTH-TYPE TRANSCRIPTIONAL REPRESSOR ALLR; 1.
DR Pfam; PF09339; HTH_IclR; 1.
DR Pfam; PF01614; IclR; 1.
DR SMART; SM00346; HTH_ICLR; 1.
DR SUPFAM; SSF55781; GAF domain-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51077; HTH_ICLR; 1.
DR PROSITE; PS51078; ICLR_ED; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000064844};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 5..67
FT /note="HTH iclR-type"
FT /evidence="ECO:0000259|PROSITE:PS51077"
FT DOMAIN 68..254
FT /note="IclR-ED"
FT /evidence="ECO:0000259|PROSITE:PS51078"
SQ SEQUENCE 254 AA; 28417 MW; A9B9022F1ED6D0A9 CRC64;
MAETIQSVDR ALEVLIYLEA ADQETSITKM ASDMGVYKST IYRTLATLEA RGFVRKNPDT
DRYWLGNRLF SLGKSVENHL GIQEVVRPSA RKLYEAYHET VNVAILERDH DEVYRSVIVL
KEEGGHQMLT VNLPVGASVE CHSTSGGKCL LAFGRNIDLS VYEKRPLHAY TDRTITSATE
LRAELEQVRR QGYAMDRDEM EHGLTCIGVP ILREDGTALA AISLSGPTSR MLSGDLDERV
EAVKRIAREI AARF
//
