ID A0A0S2W6K0_9FIRM Unreviewed; 427 AA.
AC A0A0S2W6K0;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 35.
DE SubName: Full=O-acetylhomoserine sulfhydrylase {ECO:0000313|EMBL:ALP94980.1};
DE EC=2.5.1.48 {ECO:0000313|EMBL:ALP94980.1};
DE EC=2.5.1.49 {ECO:0000313|EMBL:ALP94980.1};
GN ORFNames=IB211_02589c {ECO:0000313|EMBL:ALP94980.1};
OS Intestinimonas butyriciproducens.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Intestinimonas.
OX NCBI_TaxID=1297617 {ECO:0000313|EMBL:ALP94980.1, ECO:0000313|Proteomes:UP000064844};
RN [1] {ECO:0000313|EMBL:ALP94980.1, ECO:0000313|Proteomes:UP000064844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF211 {ECO:0000313|EMBL:ALP94980.1,
RC ECO:0000313|Proteomes:UP000064844};
RX PubMed=26620920; DOI=10.1038/ncomms10062;
RA Bui T.P., Ritari J., Boeren S., de Waard P., Plugge C.M., de Vos W.M.;
RT "Production of butyrate from lysine and the Amadori product fructoselysine
RT by a human gut commensal.";
RL Nat. Commun. 6:10062-10062(2015).
RN [2] {ECO:0000313|Proteomes:UP000064844}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AF211 {ECO:0000313|Proteomes:UP000064844};
RA de Vos W.M., Bui N.T.P., Plugge C.M., Ritari J.;
RT "A butyrogenic pathway from the amino acid lysine in a human gut
RT commensal.";
RL Submitted (APR-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
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DR EMBL; CP011307; ALP94980.1; -; Genomic_DNA.
DR RefSeq; WP_033117375.1; NZ_MJII01000001.1.
DR AlphaFoldDB; A0A0S2W6K0; -.
DR STRING; 1297617.IB211_02589c; -.
DR GeneID; 60291979; -.
DR KEGG; ibu:IB211_02589c; -.
DR PATRIC; fig|1297617.4.peg.2665; -.
DR eggNOG; COG2873; Bacteria.
DR Proteomes; UP000064844; Chromosome.
DR GO; GO:0003962; F:cystathionine gamma-synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0102028; F:cystathionine gamma-synthase activity (acts on O-phosphohomoserine); IEA:UniProtKB-EC.
DR GO; GO:0003961; F:O-acetylhomoserine aminocarboxypropyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF3; O-ACETYLHOMOSERINE SULFHYDRYLASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
PE 3: Inferred from homology;
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000064844};
KW Transferase {ECO:0000313|EMBL:ALP94980.1}.
FT MOD_RES 207
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 427 AA; 45704 MW; 766CBE879D002D39 CRC64;
MSEYQPSTNC LHAGYVPGSG EPRNIPIVQS TTFRYATGEA MGALFDLEAE GYFYTRLQNP
TNDQVAAKIC ALEGGTAAML TSSGQAANFF AIFNIASCGD HVVASSAIYG GTFNLFAVTM
KRMGIDFTFV GPDCTEEELE AAFRPNTKAV FGETIANPAL TVLDIEKFAR CAHAHGVPLI
VDNTFPTPIH CRPFQWGADI VTHSTTKYMD GHANAVGGAI VDSGKFDWNR YADKFPGLTT
PDESYHGITY TERFGLGGAY ITKATAQLMR DFGATPAPMN SYFVNVGLET LPLRVEKHCA
NAQAAAEFLA SHPKVAWVNY PGLPGNPYYA LARKYMPDGT CGVVSFGVQG GREAASRFMA
GLKLASIATH VADAKTCVLH PASTTHRQMN DEELLAAGVS ADLVRLSVGI EDPADILADL
EQALALV
//
