ID A0A0S6VPQ6_9BACT Unreviewed; 485 AA.
AC A0A0S6VPQ6;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=RNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012493};
DE EC=2.7.7.49 {ECO:0000256|ARBA:ARBA00012493};
GN ORFNames=U14_00179 {ECO:0000313|EMBL:GAK48962.1};
OS Candidatus Moduliflexus flocculans.
OC Bacteria; Candidatus Moduliflexota; Candidatus Moduliflexia;
OC Candidatus Moduliflexales; Candidatus Moduliflexaceae.
OX NCBI_TaxID=1499966 {ECO:0000313|EMBL:GAK48962.1};
RN [1] {ECO:0000313|EMBL:GAK48962.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Sekiguchi Y., Ohashi A., Parks D.H., Yamauchi T., Tyson G.W.,
RA Hugenholtz P.;
RT "First genomic representation of candidate bacterial phylum KSB3 points to
RT enhanced environmental sensing as a trigger of wastewater bulking.";
RL PeerJ 3:e740-e740(2015).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.49;
CC Evidence={ECO:0000256|ARBA:ARBA00024557};
CC -!- SIMILARITY: Belongs to the bacterial reverse transcriptase family.
CC {ECO:0000256|ARBA:ARBA00034120}.
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DR EMBL; DF820455; GAK48962.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S6VPQ6; -.
DR STRING; 1499966.U14_00179; -.
DR HOGENOM; CLU_028398_4_0_0; -.
DR Proteomes; UP000030700; Unassembled WGS sequence.
DR GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR GO; GO:0003964; F:RNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0051607; P:defense response to virus; IEA:UniProtKB-KW.
DR CDD; cd03487; RT_Bac_retron_II; 1.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR000123; Reverse_transcriptase_msDNA.
DR InterPro; IPR000477; RT_dom.
DR PANTHER; PTHR34047; NUCLEAR INTRON MATURASE 1, MITOCHONDRIAL-RELATED; 1.
DR PANTHER; PTHR34047:SF7; RNA-DIRECTED DNA POLYMERASE; 1.
DR Pfam; PF00078; RVT_1; 1.
DR PRINTS; PR00866; RNADNAPOLMS.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR PROSITE; PS50878; RT_POL; 1.
PE 3: Inferred from homology;
KW Antiviral defense {ECO:0000256|ARBA:ARBA00023118};
KW Nucleotidyltransferase {ECO:0000313|EMBL:GAK48962.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000030700};
KW RNA-directed DNA polymerase {ECO:0000313|EMBL:GAK48962.1};
KW Transferase {ECO:0000313|EMBL:GAK48962.1}.
FT DOMAIN 183..415
FT /note="Reverse transcriptase"
FT /evidence="ECO:0000259|PROSITE:PS50878"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 99..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 11..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 485 AA; 55518 MW; 6EA675FD0AC39869 CRC64;
MFEGFRDSHF PLNDMSNTEN SQDSRLSRQQ IYDRIRATSK QEYILSEMVR LGFWPDSQDA
PTLPEQLIRR EGELTRELTE LLEKQRKFDN REQMFKEMRK KRLEESHQKQ AETKERRQRE
RDERARRWKE LKAQDIGYLG DGVSGGLQNK EHSAERLAQN NLPAFASVAE LVQAMGISVG
ELRFLTFQRD VSKVSHYKRF YMPKKSGGMR LISAPMPRLK AAQHWVLEHL LQTVPLHPAA
RGFRSGESIV TNAAPHVGRD VVINLDVKDF FPTVSYPRVK GVFRGLGYSE QLATIFALLC
TEPDVDALEL DGETYYVVAS GRHLPQGAPT SPALTNILCR RLDSRLSGMA QKMGFAYTRY
ADDMTFSGTE DTLQNLTKLL WRAKKIISDE GFVVHPGKLR IMRSGSRQEV TGIVVNEQMT
LERGTLRNFR ALLFQIEKDG LRGKTWKGRE LTPASLRGLA HYIVMVNPQK GRPLLERVNA
LLRQA
//
