ID A0A0S6WXW0_9SPHN Unreviewed; 322 AA.
AC A0A0S6WXW0;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=NAD-binding D-isomer specific 2-hydroxyacid dehydrogenase {ECO:0000313|EMBL:GAM04013.1};
GN ORFNames=MBENS4_1011 {ECO:0000313|EMBL:GAM04013.1};
OS Novosphingobium sp. MBES04.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC Sphingomonadaceae; Novosphingobium.
OX NCBI_TaxID=1206458 {ECO:0000313|EMBL:GAM04013.1};
RN [1] {ECO:0000313|EMBL:GAM04013.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MBES04 {ECO:0000313|EMBL:GAM04013.1};
RA Ohta Y., Nishi S., Kobayashi K., Tsubouchi T., Iida K., Tanizaki A.,
RA Kurosawa K., Adachi A., Nishihara M., Sato R., Hasegawa R., Hatada Y.;
RT "Draft Genome Sequence of Novosphingobium sp. Strain MBES04, Isolated from
RT Sunken Wood from Suruga Bay, Japan.";
RL Genome Announc. 3:e01373-14(2015).
CC -!- SIMILARITY: Belongs to the D-isomer specific 2-hydroxyacid
CC dehydrogenase family. {ECO:0000256|RuleBase:RU003719}.
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DR EMBL; DF850488; GAM04013.1; -; Genomic_DNA.
DR RefSeq; WP_039389174.1; NZ_DF850488.1.
DR AlphaFoldDB; A0A0S6WXW0; -.
DR STRING; 1206458.MBENS4_1011; -.
DR HOGENOM; CLU_019796_1_2_5; -.
DR OrthoDB; 9793626at2; -.
DR Proteomes; UP000053513; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR CDD; cd05301; GDH; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 2.
DR InterPro; IPR006139; D-isomer_2_OHA_DH_cat_dom.
DR InterPro; IPR006140; D-isomer_DH_NAD-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR10996:SF178; 2-HYDROXYACID DEHYDROGENASE YGL185C-RELATED; 1.
DR PANTHER; PTHR10996; 2-HYDROXYACID DEHYDROGENASE-RELATED; 1.
DR Pfam; PF00389; 2-Hacid_dh; 1.
DR Pfam; PF02826; 2-Hacid_dh_C; 1.
DR SUPFAM; SSF52283; Formate/glycerate dehydrogenase catalytic domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Oxidoreductase {ECO:0000256|RuleBase:RU003719}.
FT DOMAIN 8..320
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase
FT catalytic"
FT /evidence="ECO:0000259|Pfam:PF00389"
FT DOMAIN 112..291
FT /note="D-isomer specific 2-hydroxyacid dehydrogenase NAD-
FT binding"
FT /evidence="ECO:0000259|Pfam:PF02826"
SQ SEQUENCE 322 AA; 34861 MW; 09A72AD2353EA425 CRC64;
MSAKPRILLT RRWPERVEAL LAERYDATLS TDDRPLSEAE LTVAMREYDA ILPTITDKLP
AGILSVEGRR VRMIANYGAG FEHVDLAAAK AAGIIVSNTP GVLTDATADI AVTLMLMAAR
RAGEGERELR AGQWTGWRPT HLLGTGLRGK TLGLVGFGRI AQAMAERARF GFGMDVAYYS
RRPKPEDAKR FDARYFASLT QLAQQCDFLS LHIPGGAETR NMINAAVLEQ MPSHAVLINT
ARGDVVDEVA LADALESGGI AGAALDVFVG EPHVSQRLLV APNTVLLPHL GSATRETREA
MGMRALANLD DWHAGRVPRD SL
//
