ID   A0A0S6X1X1_9SPHN        Unreviewed;       324 AA.
AC   A0A0S6X1X1;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   13-SEP-2023, entry version 29.
DE   RecName: Full=Histidinol dehydrogenase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=MBENS4_2247 {ECO:0000313|EMBL:GAM05249.1};
OS   Novosphingobium sp. MBES04.
OC   Bacteria; Pseudomonadota; Alphaproteobacteria; Sphingomonadales;
OC   Sphingomonadaceae; Novosphingobium.
OX   NCBI_TaxID=1206458 {ECO:0000313|EMBL:GAM05249.1};
RN   [1] {ECO:0000313|EMBL:GAM05249.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MBES04 {ECO:0000313|EMBL:GAM05249.1};
RA   Ohta Y., Nishi S., Kobayashi K., Tsubouchi T., Iida K., Tanizaki A.,
RA   Kurosawa K., Adachi A., Nishihara M., Sato R., Hasegawa R., Hatada Y.;
RT   "Draft Genome Sequence of Novosphingobium sp. Strain MBES04, Isolated from
RT   Sunken Wood from Suruga Bay, Japan.";
RL   Genome Announc. 3:e01373-14(2015).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- SIMILARITY: Belongs to the histidinol dehydrogenase family.
CC       {ECO:0000256|RuleBase:RU004175}.
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DR   EMBL; DF850488; GAM05249.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A0S6X1X1; -.
DR   STRING; 1206458.MBENS4_2247; -.
DR   HOGENOM; CLU_006732_3_2_5; -.
DR   Proteomes; UP000053513; Unassembled WGS sequence.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   Gene3D; 3.40.50.1980; Nitrogenase molybdenum iron protein domain; 2.
DR   InterPro; IPR016161; Ald_DH/histidinol_DH.
DR   InterPro; IPR001692; Histidinol_DH_CS.
DR   InterPro; IPR012131; Hstdl_DH.
DR   NCBIfam; TIGR00069; hisD; 1.
DR   PANTHER; PTHR21256:SF14; HISTIDINOL DEHYDROGENASE; 1.
DR   PANTHER; PTHR21256; HISTIDINOL DEHYDROGENASE HDH; 1.
DR   Pfam; PF00815; Histidinol_dh; 1.
DR   PRINTS; PR00083; HOLDHDRGNASE.
DR   SUPFAM; SSF53720; ALDH-like; 1.
DR   PROSITE; PS00611; HISOL_DEHYDROGENASE; 1.
PE   3: Inferred from homology;
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT   REGION          253..324
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        305..324
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   324 AA;  34504 MW;  9A4C91E1A686D891 CRC64;
     MKMAQYLKRG ASAETRADAD RKVRDIVEAA LADIEQRGDA AVRDMSIRFD GWDREDYRLT
     DAEIEACVDS LTPQERKDIE FAQTQVRNFA QVQRASMKDV EVETLPGVIL GHKNIPLNSA
     GCYVPGGKYP LLAGAHMSVI TAKVAGVKRV VTCAPPFQGR PARAIVAAQA LAGADVIYAL
     GGIQAVGAMA IGTASIDPVD ILVGPGNAFV AEAKRQLFGR VGIDLFAGPT ETLIIADEVG
     CDPEIAATDI LGQVEHGPDS PGASSPIRKS SRAKRWPRSS ASCRSSPPPN MPARPGRPSA
     RSSWPTAPRK WSQSPTRSPP STSR
//