ID A0A0S7BKP0_9CHLR Unreviewed; 584 AA.
AC A0A0S7BKP0;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 24-JAN-2024, entry version 33.
DE RecName: Full=DNA mismatch repair protein MutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN Name=mutL {ECO:0000256|HAMAP-Rule:MF_00149};
GN ORFNames=LARV_02141 {ECO:0000313|EMBL:GAP14373.1};
OS Longilinea arvoryzae.
OC Bacteria; Chloroflexota; Anaerolineae; Anaerolineales; Anaerolineaceae;
OC Longilinea.
OX NCBI_TaxID=360412 {ECO:0000313|EMBL:GAP14373.1};
RN [1] {ECO:0000313|EMBL:GAP14373.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=KOME-1 {ECO:0000313|EMBL:GAP14373.1};
RA Sekiguchi Y., Ohashi A., Matsuura N., Tourlousse M.D.;
RT "Draft Genome Sequences of Anaerolinea thermolimosa IMO-1, Bellilinea
RT caldifistulae GOMI-1, Leptolinea tardivitalis YMTK-2, Levilinea
RT saccharolytica KIBI-1,Longilinea arvoryzae KOME-1, Previously Described as
RT Members of the Anaerolineaceae (Chloroflexi).";
RL Submitted (JUL-2015) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: This protein is involved in the repair of mismatches in DNA.
CC It is required for dam-dependent methyl-directed DNA mismatch repair.
CC May act as a 'molecular matchmaker', a protein that promotes the
CC formation of a stable complex between two or more DNA-binding proteins
CC in an ATP-dependent manner without itself being part of a final
CC effector complex. {ECO:0000256|HAMAP-Rule:MF_00149}.
CC -!- SIMILARITY: Belongs to the DNA mismatch repair MutL/HexB family.
CC {ECO:0000256|ARBA:ARBA00006082, ECO:0000256|HAMAP-Rule:MF_00149}.
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DR EMBL; DF967972; GAP14373.1; -; Genomic_DNA.
DR RefSeq; WP_075073636.1; NZ_DF967972.1.
DR AlphaFoldDB; A0A0S7BKP0; -.
DR STRING; 360412.LARV_02141; -.
DR OrthoDB; 9763467at2; -.
DR Proteomes; UP000055060; Unassembled WGS sequence.
DR GO; GO:0032300; C:mismatch repair complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0140664; F:ATP-dependent DNA damage sensor activity; IEA:InterPro.
DR GO; GO:0030983; F:mismatched DNA binding; IEA:InterPro.
DR GO; GO:0006298; P:mismatch repair; IEA:UniProtKB-UniRule.
DR CDD; cd16926; HATPase_MutL-MLH-PMS-like; 1.
DR CDD; cd00782; MutL_Trans; 1.
DR Gene3D; 3.30.230.10; -; 1.
DR Gene3D; 3.30.565.10; Histidine kinase-like ATPase, C-terminal domain; 1.
DR Gene3D; 3.30.1540.20; MutL, C-terminal domain, dimerisation subdomain; 1.
DR Gene3D; 3.30.1370.100; MutL, C-terminal domain, regulatory subdomain; 1.
DR HAMAP; MF_00149; DNA_mis_repair; 1.
DR InterPro; IPR014762; DNA_mismatch_repair_CS.
DR InterPro; IPR020667; DNA_mismatch_repair_MutL.
DR InterPro; IPR013507; DNA_mismatch_S5_2-like.
DR InterPro; IPR036890; HATPase_C_sf.
DR InterPro; IPR002099; MutL/Mlh/PMS.
DR InterPro; IPR038973; MutL/Mlh/Pms-like.
DR InterPro; IPR014790; MutL_C.
DR InterPro; IPR042120; MutL_C_dimsub.
DR InterPro; IPR042121; MutL_C_regsub.
DR InterPro; IPR037198; MutL_C_sf.
DR InterPro; IPR020568; Ribosomal_Su5_D2-typ_SF.
DR InterPro; IPR014721; Ribsml_uS5_D2-typ_fold_subgr.
DR NCBIfam; TIGR00585; mutl; 1.
DR PANTHER; PTHR10073; DNA MISMATCH REPAIR PROTEIN MLH, PMS, MUTL; 1.
DR PANTHER; PTHR10073:SF12; DNA MISMATCH REPAIR PROTEIN MLH1; 1.
DR Pfam; PF01119; DNA_mis_repair; 1.
DR Pfam; PF13589; HATPase_c_3; 1.
DR Pfam; PF08676; MutL_C; 1.
DR SMART; SM01340; DNA_mis_repair; 1.
DR SMART; SM00853; MutL_C; 1.
DR SUPFAM; SSF55874; ATPase domain of HSP90 chaperone/DNA topoisomerase II/histidine kinase; 1.
DR SUPFAM; SSF118116; DNA mismatch repair protein MutL; 1.
DR SUPFAM; SSF54211; Ribosomal protein S5 domain 2-like; 1.
DR PROSITE; PS00058; DNA_MISMATCH_REPAIR_1; 1.
PE 3: Inferred from homology;
KW DNA damage {ECO:0000256|ARBA:ARBA00022763, ECO:0000256|HAMAP-
KW Rule:MF_00149};
KW DNA repair {ECO:0000256|ARBA:ARBA00023204, ECO:0000256|HAMAP-
KW Rule:MF_00149}; Reference proteome {ECO:0000313|Proteomes:UP000055060}.
FT DOMAIN 208..326
FT /note="DNA mismatch repair protein S5"
FT /evidence="ECO:0000259|SMART:SM01340"
FT DOMAIN 396..538
FT /note="MutL C-terminal dimerisation"
FT /evidence="ECO:0000259|SMART:SM00853"
SQ SEQUENCE 584 AA; 63934 MW; 002F850C23C722A3 CRC64;
MPIQILSDDV ASQIAAGEVV ERPASVVKEL LENSLDAGAR SINIRIEGAG QRLIEVSDDG
DGISQGELTL AVARHATSKL RTAEDLFHIT TLGFRGEALA SIASVSRFSI TTRRTGAEVG
SHIRVEGGAA RPVEGAGGPE GTEVRVEDLF FNVPARLKFL KHDSTERGQI DGLVTRYALA
YPQVRFQLWQ DNRATLKTSG NGDRREILAQ LYGIEIARQL LEVNSDEDGR HMNGFISPVA
LTRSNRRDIT FFINGRWVQS VPLTTALVQA YHTLLMVGRF PLAVVFLNLP PEEVDVNVHP
AKAEVRFREP ERIFSLVQRG TRRALLAYSP VPSIGLPQWQ TAAAQPRVID PAWDMAADLK
SDSRPAELPE EALVPSETVG AAPVELPSGQ LPLLRLIGQV GLSYLVAEGP DGLYLIDQHA
AHERVLFERL MKQVAGKSIP AQALIEPAVV TFPPQQAGLF SHQMDALEHI GFQIEPFGPA
SFRVRAIPAL LVSMDPAAAL RVLVEDFEED ENPLRSEIEG RVAARVCKRA AVKAGQAMSI
EEQKKLVADL ETCQSPRTCP HGRPTMIHLS VDLLERQFGR RGSR
//
