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Database: UniProt
Entry: A0A0S7YJV0_9DELT
LinkDB: A0A0S7YJV0_9DELT
Original site: A0A0S7YJV0_9DELT 
ID   A0A0S7YJV0_9DELT        Unreviewed;       453 AA.
AC   A0A0S7YJV0;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   20-DEC-2017, entry version 13.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   ORFNames=AMJ54_16140 {ECO:0000313|EMBL:KPJ74997.1};
OS   Deltaproteobacteria bacterium SG8_13.
OC   Bacteria; Proteobacteria; Deltaproteobacteria.
OX   NCBI_TaxID=1703398 {ECO:0000313|EMBL:KPJ74997.1, ECO:0000313|Proteomes:UP000051346};
RN   [1] {ECO:0000313|EMBL:KPJ74997.1, ECO:0000313|Proteomes:UP000051346}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SG8_13 {ECO:0000313|EMBL:KPJ74997.1};
RX   PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA   Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT   "Genomic resolution of linkages in carbon, nitrogen, and sulfur
RT   cycling among widespread estuary sediment bacteria.";
RL   Microbiome 3:14-14(2015).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KPJ74997.1}.
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DR   EMBL; LJNK01000091; KPJ74997.1; -; Genomic_DNA.
DR   PATRIC; fig|1703398.3.peg.3465; -.
DR   Proteomes; UP000051346; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   PANTHER; PTHR30008; PTHR30008; 1.
DR   Pfam; PF02601; Exonuc_VII_L; 1.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000051346};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000051346}.
FT   DOMAIN       11    103       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      127    439       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   COILED      356    376       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   453 AA;  51161 MW;  1DF9A84CD066B38D CRC64;
     MDISQKQPHV YSVSELNARI KSILEERFPF VWVGGEVSNF AVPASGHFYF TLKDETAQVR
     AVMFKGQNRN LRFELKDGMA VTGIGRVSVY EPRGTYQVIF EHLEPKGTGA LQIAFEQLKK
     RLADEGLFDE RHKDPLPFLP AKIHVITSPT GAVVHDILQV VERRFSGMSL SVIPVKVQGD
     GAIEEIVAAL QLLDDCEDAE VAILARGGGS LEDLQAFNSE AVARSIFAAQ TPIVSAVGHE
     TDFTIADFVA DLRAPTPSAA AELVVPRRQD LIDKTTQYKE DLIYYLNHRI EFMRQRISDL
     TRRLADPKKK VDDQRLRIDD QIYRLQLAIE NDFRRRRQRL ILYTDKLLYN NPNICLQNLK
     RKLDLLQERF THAVDDQARS RRFRLREVSA VLSGLSPRAV LQRGYSITRT IPTAEIVRAS
     DAVDVGQDVE VLLARGALTC GVKEKREDGQ KIL
//
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