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Database: UniProt
Entry: A0A0S7ZRM5_9SPIR
LinkDB: A0A0S7ZRM5_9SPIR
Original site: A0A0S7ZRM5_9SPIR 
ID   A0A0S7ZRM5_9SPIR        Unreviewed;       410 AA.
AC   A0A0S7ZRM5;
DT   17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT   17-FEB-2016, sequence version 1.
DT   25-OCT-2017, entry version 12.
DE   RecName: Full=Exodeoxyribonuclease 7 large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            EC=3.1.11.6 {ECO:0000256|HAMAP-Rule:MF_00378};
DE   AltName: Full=Exodeoxyribonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
DE            Short=Exonuclease VII large subunit {ECO:0000256|HAMAP-Rule:MF_00378};
GN   Name=xseA {ECO:0000256|HAMAP-Rule:MF_00378};
GN   ORFNames=AMS17_01570 {ECO:0000313|EMBL:KPJ89551.1};
OS   Spirochaetes bacterium DG_61.
OC   Bacteria; Spirochaetes.
OX   NCBI_TaxID=1704237 {ECO:0000313|EMBL:KPJ89551.1, ECO:0000313|Proteomes:UP000050987};
RN   [1] {ECO:0000313|EMBL:KPJ89551.1, ECO:0000313|Proteomes:UP000050987}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DG_61 {ECO:0000313|EMBL:KPJ89551.1};
RX   PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA   Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT   "Genomic resolution of linkages in carbon, nitrogen, and sulfur
RT   cycling among widespread estuary sediment bacteria.";
RL   Microbiome 3:14-14(2015).
CC   -!- FUNCTION: Bidirectionally degrades single-stranded DNA into large
CC       acid-insoluble oligonucleotides, which are then degraded further
CC       into small acid-soluble oligonucleotides. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|SAAS:SAAS00723532}.
CC   -!- CATALYTIC ACTIVITY: Exonucleolytic cleavage in either 5'- to
CC       3'- or 3'- to 5'-direction to yield nucleoside 5'-phosphates.
CC       {ECO:0000256|HAMAP-Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723505}.
CC   -!- SUBUNIT: Heterooligomer composed of large and small subunits.
CC       {ECO:0000256|HAMAP-Rule:MF_00378}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
CC       ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723552}.
CC   -!- SIMILARITY: Belongs to the XseA family. {ECO:0000256|HAMAP-
CC       Rule:MF_00378, ECO:0000256|RuleBase:RU004355,
CC       ECO:0000256|SAAS:SAAS00723548}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:KPJ89551.1}.
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DR   EMBL; LJNB01000013; KPJ89551.1; -; Genomic_DNA.
DR   PATRIC; fig|1704237.3.peg.4401; -.
DR   Proteomes; UP000050987; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0009318; C:exodeoxyribonuclease VII complex; IEA:InterPro.
DR   GO; GO:0008855; F:exodeoxyribonuclease VII activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0003676; F:nucleic acid binding; IEA:InterPro.
DR   GO; GO:0006308; P:DNA catabolic process; IEA:UniProtKB-UniRule.
DR   CDD; cd04489; ExoVII_LU_OBF; 1.
DR   Gene3D; 3.40.50.261; -; 1.
DR   HAMAP; MF_00378; Exonuc_7_L; 1.
DR   InterPro; IPR003753; Exonuc_VII_L.
DR   InterPro; IPR020579; Exonuc_VII_lsu_C.
DR   InterPro; IPR025824; OB-fold_nuc-bd_dom.
DR   InterPro; IPR016102; Succinyl-CoA_synth-like.
DR   PANTHER; PTHR30008; PTHR30008; 2.
DR   Pfam; PF02601; Exonuc_VII_L; 2.
DR   Pfam; PF13742; tRNA_anti_2; 1.
DR   TIGRFAMs; TIGR00237; xseA; 1.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Complete proteome {ECO:0000313|Proteomes:UP000050987};
KW   Cytoplasm {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|SAAS:SAAS00723549};
KW   Exonuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723511};
KW   Hydrolase {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723558};
KW   Nuclease {ECO:0000256|HAMAP-Rule:MF_00378,
KW   ECO:0000256|RuleBase:RU004355, ECO:0000256|SAAS:SAAS00723518};
KW   Reference proteome {ECO:0000313|Proteomes:UP000050987}.
FT   DOMAIN        8    100       tRNA_anti_2. {ECO:0000259|Pfam:PF13742}.
FT   DOMAIN      124    337       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   DOMAIN      334    391       Exonuc_VII_L. {ECO:0000259|Pfam:PF02601}.
FT   COILED      303    330       {ECO:0000256|SAM:Coils}.
SQ   SEQUENCE   410 AA;  46382 MW;  ECF9EBFE5C652163 CRC64;
     MDMERVIFSV SEITKRIKHL LEETFPDIWV RGEISNLRTA SSGHIYFTLK DEGAVIKAVL
     FRGYQRAIPF EPEDGMNVIV HGNIDVFDKR GEYQIIVDLM EPEGIGALQL AFEQLKEKLH
     KEGLFDEAHK KNIPAFPDTI GIVTSPTGAA LRDILNIVDR RYRGIRVIIY PVLVQGEGAA
     EEIAEAIRKA NQRREVDVLI VARGGGSIED LWPFNEEMVA RAIYDSHIPI ISAVGHEIDF
     TISDFVADLR APTPSAAAEL VVKNKIELLR WSRELIIRLY NSLDRMLVSR REKAALYSTE
     LLVRRMTQLL QQKSQILDDL ERNLSVQMEA LLIKIRGRFE KAVGQLNALS PLNTLARGFA
     VISRLPENWP VFSVQDVSER DEIKAKLKDG LLFSTIYRIE KAQPDGDGDT
//
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