ID A0A0S8AAD8_9GAMM Unreviewed; 292 AA.
AC A0A0S8AAD8;
DT 17-FEB-2016, integrated into UniProtKB/TrEMBL.
DT 17-FEB-2016, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Hydroxyacid dehydrogenase {ECO:0008006|Google:ProtNLM};
GN ORFNames=AMJ55_02305 {ECO:0000313|EMBL:KPJ96312.1};
OS Gammaproteobacteria bacterium SG8_15.
OC Bacteria; Pseudomonadota; Gammaproteobacteria.
OX NCBI_TaxID=1703403 {ECO:0000313|EMBL:KPJ96312.1, ECO:0000313|Proteomes:UP000053644};
RN [1] {ECO:0000313|EMBL:KPJ96312.1, ECO:0000313|Proteomes:UP000053644}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SG8_15 {ECO:0000313|EMBL:KPJ96312.1};
RX PubMed=25922666; DOI=10.1186/s40168-015-0077-6;
RA Baker B.J., Lazar C.S., Teske A.P., Dick G.J.;
RT "Genomic resolution of linkages in carbon, nitrogen, and sulfur cycling
RT among widespread estuary sediment bacteria.";
RL Microbiome 3:14-14(2015).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:KPJ96312.1}.
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DR EMBL; LJNL01000026; KPJ96312.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A0S8AAD8; -.
DR Proteomes; UP000053644; Unassembled WGS sequence.
DR GO; GO:0051287; F:NAD binding; IEA:InterPro.
DR GO; GO:0050661; F:NADP binding; IEA:InterPro.
DR GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR GO; GO:0016054; P:organic acid catabolic process; IEA:UniProt.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR008927; 6-PGluconate_DH-like_C_sf.
DR InterPro; IPR013328; 6PGD_dom2.
DR InterPro; IPR006115; 6PGDH_NADP-bd.
DR InterPro; IPR029154; HIBADH-like_NADP-bd.
DR InterPro; IPR015815; HIBADH-related.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR43580; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR PANTHER; PTHR43580:SF2; OXIDOREDUCTASE GLYR1-RELATED; 1.
DR Pfam; PF14833; NAD_binding_11; 1.
DR Pfam; PF03446; NAD_binding_2; 1.
DR PIRSF; PIRSF000103; HIBADH; 1.
DR SUPFAM; SSF48179; 6-phosphogluconate dehydrogenase C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW NAD {ECO:0000256|ARBA:ARBA00023027};
KW Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT DOMAIN 5..159
FT /note="6-phosphogluconate dehydrogenase NADP-binding"
FT /evidence="ECO:0000259|Pfam:PF03446"
FT DOMAIN 164..283
FT /note="3-hydroxyisobutyrate dehydrogenase-like NAD-binding"
FT /evidence="ECO:0000259|Pfam:PF14833"
FT ACT_SITE 170
FT /evidence="ECO:0000256|PIRSR:PIRSR000103-1"
SQ SEQUENCE 292 AA; 31800 MW; C83F6821CFBD9433 CRC64;
MSETVSLFGA GAMGEAIARC LLAKHYQLNV WSRTPEKLVT LAEAGAIVKS SAANAIKSAD
IIVCVLPDVV AIQEALFDVE WAHELHGRTV INFGAVNTSR SQALMDAFQA HQASYVEVAA
IGSADDVANG NLQLLVGAAK QDYQRVSGLL HELSNRISFV GDVGDAVALK LAMQQMAATL
FCAFSSSISM IKEQGLDVDV FLDFLRASPL YTPLFDQKLP RILGRDYARA SLPARHLERD
LKLFLEEAEE LGLNVHYVES VKELIGLCVA RGMQDMDYTA VYDIINPPKE DD
//
